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MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
Huang W, Chen J, Liu X, Liu X, Duan S, Chen L, Liu X, Lan J, Zou Y, Guo D, Zhou J. Huang W, et al. Exp Cell Res. 2021 Sep 1;406(1):112722. doi: 10.1016/j.yexcr.2021.112722. Epub 2021 Jul 6. Exp Cell Res. 2021. PMID: 34242623
Breast cancer is one of the most frequently diagnosed cancers and the leading cause of cancer death in women. ...The effect of MIER3 on proliferation and migration of breast cancer cells was detected in vitro and in vivo. ...
Breast cancer is one of the most frequently diagnosed cancers and the leading cause of cancer death in women. ...The ef …
MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition.
Peng M, Hu Y, Song W, Duan S, Xu Q, Ding Y, Geng J, Zhou J. Peng M, et al. Sci Rep. 2017 Sep 8;7(1):11000. doi: 10.1038/s41598-017-11374-y. Sci Rep. 2017. PMID: 28887525 Free PMC article.
Mesoderm induction early response 1, family member 3 (MIER3) has recently been identified as a potential cancer susceptibility gene. However, the expression pattern and the role of MIER3 in the progression of colorectal cancer (CRC) have not yet been w …
Mesoderm induction early response 1, family member 3 (MIER3) has recently been identified as a potential cancer susceptibility …
MIER3 suppresses the progression of non-small cell lung cancer by inhibiting Wnt/beta-Catenin pathway and histone acetyltransferase activity.
Zhang H, Wang L, Bai J, Jiao W, Wang M. Zhang H, et al. Transl Cancer Res. 2020 Jan;9(1):346-357. doi: 10.21037/tcr.2020.01.07. Transl Cancer Res. 2020. PMID: 35117188 Free PMC article.
BACKGROUND: The mesoderm induction early response 1, family member 3 (MIER3) gene has been recognized as potentially being associated with cancer. However, in relation to the development of non-small cell lung cancer (NSCLC), the expression pattern and the ro …
BACKGROUND: The mesoderm induction early response 1, family member 3 (MIER3) gene has been recognized as potentially being associated …
[Expression of MIER3 in colorectal cancer and bioinformatic analysis of MIER3- interacting proteins].
Song W, Peng M, Duan SY, Lin C, Xu Q, Zhou J. Song W, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2017 Aug 20;37(8):1040-1046. doi: 10.3969/j.issn.1673-4254.2017.08.07. Nan Fang Yi Ke Da Xue Xue Bao. 2017. PMID: 28801283 Free PMC article. Chinese.
OBJECTIVE: To explore role of MIER3 gene in the development and progression of human colorectal carcinoma (CRC) and analyze the proteins that interact with MIER3 using bioinformatic techniques. ...Bioinformatics analyses indicated that NAT9 was a potential MIER3 …
OBJECTIVE: To explore role of MIER3 gene in the development and progression of human colorectal carcinoma (CRC) and analyze the prote …
Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.
denDekker AD, Xu X, Vaughn MD, Puckett AH, Gardner LL, Lambring CJ, Deschenes L, Samuelson DJ. denDekker AD, et al. Cancer Res. 2012 Nov 15;72(22):6002-12. doi: 10.1158/0008-5472.CAN-12-0748. Epub 2012 Sep 19. Cancer Res. 2012. PMID: 22993404 Free PMC article.
Human/rat MAP3K1/Map3k1 and mesoderm induction early response (MIER; MIER3)/MIER3 are within these orthologous segments. We identified MIER3 as a candidate Mcs1b gene based on 4.5-fold higher mammary gland levels of MIER3 transcripts in susceptible com …
Human/rat MAP3K1/Map3k1 and mesoderm induction early response (MIER; MIER3)/MIER3 are within these orthologous segments. We id …
Differential HDAC1 and 2 Recruitment by Members of the MIER Family.
Derwish R, Paterno GD, Gillespie LL. Derwish R, et al. PLoS One. 2017 Jan 3;12(1):e0169338. doi: 10.1371/journal.pone.0169338. eCollection 2017. PLoS One. 2017. PMID: 28046085 Free PMC article.
In this report, we investigate MIER2 and MIER3 localization and function. Confocal analysis revealed that, while MIER2 and MIER3 are mainly nuclear proteins, a substantial proportion (32%) of MIER2 is localized in the cytoplasm. ...By contrast, HDAC1 and 2 were read …
In this report, we investigate MIER2 and MIER3 localization and function. Confocal analysis revealed that, while MIER2 and MIER3 …
Differential expression and prognostic role of selected genes in colorectal cancer patients.
Pitule P, Vycital O, Bruha J, Novak P, Hosek P, Treska V, Hlavata I, Soucek P, Kralickova M, Liska V. Pitule P, et al. Anticancer Res. 2013 Nov;33(11):4855-65. Anticancer Res. 2013. PMID: 24222123
Six genes were down-regulated: destrin (DSTN; p=0.004), mesoderm induction early response 1, family member 3 (MIER3; p<0.001), acyl-CoA synthetase long-chain family member 5 (ACSL5; p=0.002), mitogen-activated protein kinase 1/ERK (MAPK1; p<0.001), claudin 23 (CLDN23 …
Six genes were down-regulated: destrin (DSTN; p=0.004), mesoderm induction early response 1, family member 3 (MIER3; p<0.001), acy …