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The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer.
Kabra A, Bushweller J. Kabra A, et al. J Mol Biol. 2022 Jan 15;434(1):167117. doi: 10.1016/j.jmb.2021.167117. Epub 2021 Jun 23. J Mol Biol. 2022. PMID: 34174329 Free PMC article. Review.
AF9 (MLLT3) and ENL (MLLT1) are members of the YEATS family (named after the five proteins first shown to contain this domain: Yaf9, ENL, AF9, Taf14, Sas5) defined by the presence of a YEATS domain. ...Mutations in MLLT1 observed in Wilms tumor patients enhance phas …
AF9 (MLLT3) and ENL (MLLT1) are members of the YEATS family (named after the five proteins first shown to contain this domain: Yaf9, …
MLL-Rearranged Acute Lymphoblastic Leukemia.
El Chaer F, Keng M, Ballen KK. El Chaer F, et al. Curr Hematol Malig Rep. 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. Curr Hematol Malig Rep. 2020. PMID: 32350732 Review.
The most common translocated genes are AFF1 (formerly AF4), MLLT3 (formerly AF9), and MLLT1 (formerly ENL). The bimodal incidence of MLL-r-ALL usually peaks in infants in their first 2 years of life and then declines thereafter during the pediatric/young adult phase until …
The most common translocated genes are AFF1 (formerly AF4), MLLT3 (formerly AF9), and MLLT1 (formerly ENL). The bimodal incidence of …
Down-regulation of MLLT1 super elongation complex subunit impairs the anti-tumor activity of natural killer cells in esophageal cancer.
Liu C, Li X, Xiong F, Wang L, Chen K, Wu P, Hua L, Zhang Z. Liu C, et al. Immunobiology. 2022 Jul;227(4):152238. doi: 10.1016/j.imbio.2022.152238. Epub 2022 Jun 16. Immunobiology. 2022. PMID: 35763909 Free article.
In this study, we characterized the expression and function of MLLT1 super elongation complex subunit (MLLT1) in esophageal NK cells in a mouse EC model. ...Therefore, this study indicated that TIM-3 signaling down-regulated MLLT1 in esophageal NK cells, and …
In this study, we characterized the expression and function of MLLT1 super elongation complex subunit (MLLT1) in esophageal NK …
Exome sequencing of glioblastoma-derived cancer stem cells reveals rare clinically relevant frameshift deletion in MLLT1 gene.
Marei HE, Althani A, Afifi N, Hasan A, Caceci T, Felsani A, Tringali G, Cifola I, Pozzoli G, Cenciarelli C. Marei HE, et al. Cancer Cell Int. 2022 Jan 7;22(1):9. doi: 10.1186/s12935-021-02419-4. Cancer Cell Int. 2022. PMID: 34996478 Free PMC article.
One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem cells (CSC) which confer resistance against standard chemo- and radiotherapeutics modalities. ...CONCLUSIONS: We discovered a potentially harmful frameshift deletion at Gln461fs …
One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem cells (CSC) which confer resistance ag …
KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs.
Yan F, Li J, Milosevic J, Petroni R, Liu S, Shi Z, Yuan S, Reynaga JM, Qi Y, Rico J, Yu S, Liu Y, Rokudai S, Palmisiano N, Meyer SE, Sung PJ, Wan L, Lan F, Garcia BA, Stanger BZ, Sykes DB, Blanco MA. Yan F, et al. Cancer Discov. 2022 Mar 1;12(3):792-811. doi: 10.1158/2159-8290.CD-20-1459. Cancer Discov. 2022. PMID: 34853079 Free PMC article.
Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity.
Ui A, Yasui A. Ui A, et al. Nucleus. 2016 Apr 25;7(2):138-45. doi: 10.1080/19491034.2016.1177681. Nucleus. 2016. PMID: 27310306 Free PMC article. Review.
Polycomb group (PcG) repress, whereas Trithorax group (TrxG) activate transcription for tissue development and cellular proliferation, and misregulation of these factors is often associated with cancer. ENL (MLLT1) and AF9 (MLLT3) are fusion partners of Mixed Lineag …
Polycomb group (PcG) repress, whereas Trithorax group (TrxG) activate transcription for tissue development and cellular proliferation, and m …
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.
Gadd S, Huff V, Walz AL, Ooms AHAG, Armstrong AE, Gerhard DS, Smith MA, Auvil JMG, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Hermida LC, Davidsen T, Gesuwan P, Ma Y, Zong Z, Mungall AJ, Moore RA, Marra MA, Dome JS, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Ross N, Gastier-Foster JM, Arold ST, Perlman EJ. Gadd S, et al. Nat Genet. 2017 Oct;49(10):1487-1494. doi: 10.1038/ng.3940. Epub 2017 Aug 21. Nat Genet. 2017. PMID: 28825729 Free PMC article.
In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, and TP53), we identified mutations in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent being BCOR …
In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, …
Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Moustakim M, Christott T, Monteiro OP, Bennett J, Giroud C, Ward J, Rogers CM, Smith P, Panagakou I, Díaz-Sáez L, Felce SL, Gamble V, Gileadi C, Halidi N, Heidenreich D, Chaikuad A, Knapp S, Huber KVM, Farnie G, Heer J, Manevski N, Poda G, Al-Awar R, Dixon DJ, Brennan PE, Fedorov O. Moustakim M, et al. Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16302-16307. doi: 10.1002/anie.201810617. Epub 2018 Nov 16. Angew Chem Int Ed Engl. 2018. PMID: 30288907 Free PMC article.
Dysregulation of these modified lysine-binding proteins has been linked to the onset and progression of cancers. We herein report the discovery and characterisation of the first small-molecule chemical probe, SGC-iMLLT, for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF …
Dysregulation of these modified lysine-binding proteins has been linked to the onset and progression of cancers. We herein report the …
Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants.
Ni X, Londregan AT, Owen DR, Knapp S, Chaikuad A. Ni X, et al. ACS Chem Biol. 2021 Apr 16;16(4):571-578. doi: 10.1021/acschembio.0c00960. Epub 2021 Mar 21. ACS Chem Biol. 2021. PMID: 33749253
Dysfunction of YEATS-domain-containing MLLT1, an acetyl/acyl-lysine dependent epigenetic reader domain, has been implicated in the development of aggressive cancers. ...Our report provides a structural basis for the altered behaviors and a potential strategy for tar …
Dysfunction of YEATS-domain-containing MLLT1, an acetyl/acyl-lysine dependent epigenetic reader domain, has been implicated in the de …
MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.
Perlman EJ, Gadd S, Arold ST, Radhakrishnan A, Gerhard DS, Jennings L, Huff V, Guidry Auvil JM, Davidsen TM, Dome JS, Meerzaman D, Hsu CH, Nguyen C, Anderson J, Ma Y, Mungall AJ, Moore RA, Marra MA, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Gastier-Foster JM, Ross N, Smith MA. Perlman EJ, et al. Nat Commun. 2015 Dec 4;6:10013. doi: 10.1038/ncomms10013. Nat Commun. 2015. PMID: 26635203 Free PMC article.
The mutant MLLT1 protein shows altered binding to acetylated histone tails. Moreover, MLLT1-mutant tumours show an increase in MYC gene expression and HOX dysregulation. ...
The mutant MLLT1 protein shows altered binding to acetylated histone tails. Moreover, MLLT1-mutant tumours show an increase in …
96 results