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Page 1
MRGBP promotes colorectal cancer metastasis via DKK1/Wnt/beta-catenin and NF-kB/p65 pathways mediated EMT.
Long X, Hu Y, Duan S, Liu X, Huang W, Liu X, Xu Q, Song W, Zhou J. Long X, et al. Exp Cell Res. 2022 Dec 1;421(1):113375. doi: 10.1016/j.yexcr.2022.113375. Epub 2022 Oct 5. Exp Cell Res. 2022. PMID: 36208716
MRG domain binding protein (MRGBP) has been proposed to participate in the development of multiple tumors. However, the role of MRGBP in colorectal cancer (CRC) still remains largely unknown. Here, we found that MRGBP expression is significantly elevated in C …
MRG domain binding protein (MRGBP) has been proposed to participate in the development of multiple tumors. However, the role of MR …
MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair.
Rivero S, Rodríguez-Real G, Marín I, Huertas P. Rivero S, et al. FEBS Open Bio. 2021 Mar;11(3):622-632. doi: 10.1002/2211-5463.13071. Epub 2021 Feb 20. FEBS Open Bio. 2021. PMID: 33354938 Free PMC article.
Here, we show that MRG domain binding protein (MRGBP), a member of this complex, acts as a general inhibitor of DNA double-strand break repair. ...This is particularly evident for the stimulation of early events of homologous recombination. Thus, MRGBP has an opposi …
Here, we show that MRG domain binding protein (MRGBP), a member of this complex, acts as a general inhibitor of DNA double-strand bre …
MRGBP: A New Factor for Diagnosis and Prediction of Head and Neck Squamous Cell Carcinoma.
Zhao C, Wei C, Chen X, Li P. Zhao C, et al. Biomed Res Int. 2022 Jul 25;2022:7281120. doi: 10.1155/2022/7281120. eCollection 2022. Biomed Res Int. 2022. PMID: 35924262 Free PMC article.
MRG-binding protein (MRGBP) is a transcription factor widely involved in physiological and pathological processes. ...GSEA showed that MRGBP was associated with high expression of GPCR ligand binding, interleukin receptor binding, and neutrophil degranulation, and s …
MRG-binding protein (MRGBP) is a transcription factor widely involved in physiological and pathological processes. ...GSEA showed tha …
MRGBP is a potential novel prognostic biomarker and is correlated with immune infiltrates in hepatocellular carcinoma.
Huang J, Chen X, Zhu W. Huang J, et al. Medicine (Baltimore). 2021 Mar 26;100(12):e25234. doi: 10.1097/MD.0000000000025234. Medicine (Baltimore). 2021. PMID: 33761715 Free PMC article.
This study investigated the expression change, prognostic values, and potential regulatory mechanisms of mortality factor on chromosome 4 (MORF4)-related gene-binding protein (MRGBP) in hepatocellular carcinoma (HCC).MRGBP expression and clinical data from The Cance …
This study investigated the expression change, prognostic values, and potential regulatory mechanisms of mortality factor on chromosome 4 (M …
MRGBP as a potential biomarker for the malignancy of pancreatic ductal adenocarcinoma.
Ding F, Zhang S, Gao S, Shang J, Li Y, Cui N, Zhao Q. Ding F, et al. Oncotarget. 2017 Jul 22;8(38):64224-64236. doi: 10.18632/oncotarget.19451. eCollection 2017 Sep 8. Oncotarget. 2017. PMID: 28969065 Free PMC article.
However, the expression pattern and underlying mechanism of MRGBP in pancreatic ductal adenocarcinoma (PDAC) remain unknown. In the study, we found that MRGBP was frequently upregulated in PDAC tissues and cell lines. In addition, the upregulation of MRGBP wa …
However, the expression pattern and underlying mechanism of MRGBP in pancreatic ductal adenocarcinoma (PDAC) remain unknown. In the s …
MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells.
Ito S, Kayukawa N, Ueda T, Taniguchi H, Morioka Y, Hongo F, Ukimura O. Ito S, et al. Biochim Biophys Acta Gene Regul Mech. 2018 Aug 1:S1874-9399(18)30068-3. doi: 10.1016/j.bbagrm.2018.07.014. Online ahead of print. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 30076933
This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. We first showed that MRGBP promoted growth of AR-positive prostate cancer cells. ...MRGBP was recruited to active gene regions through its binding with H3K4me1/ …
This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. We first showed that MRGBP …
Prognostic Value and Immunological Role of MORF4-Related Gene-Binding Protein in Human Cancers.
Chai D, Zhang L, Guan Y, Yuan J, Li M, Wang W. Chai D, et al. Front Cell Dev Biol. 2021 Sep 29;9:703415. doi: 10.3389/fcell.2021.703415. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34660575 Free PMC article.
In this research, the expression profile, prognostic value of MRGBP, and the relationship between MRGBP and immune infiltration were explored in 33 types of cancer. ...Furthermore, we explored MRGBP expression and the relationship between MRGBP express …
In this research, the expression profile, prognostic value of MRGBP, and the relationship between MRGBP and immune infiltratio …
MiR-137 functions as a tumor suppressor in pancreatic cancer by targeting MRGBP.
Ding F, Zhang S, Gao S, Shang J, Li Y, Cui N, Zhao Q. Ding F, et al. J Cell Biochem. 2018 Jun;119(6):4799-4807. doi: 10.1002/jcb.26676. Epub 2018 Mar 1. J Cell Biochem. 2018. Retraction in: J Cell Biochem. 2024 May;125(5):e30552. doi: 10.1002/jcb.30552. PMID: 29331027 Retracted.
Meanwhile, upregulated miR-137 remarkably inhibited migration and invasion of pancreatic cancer cells. Further studies indicated that MRGBP was identified as the direct downstream target gene of miR-137. In addition, MRGBP expression is significantly downregulated i …
Meanwhile, upregulated miR-137 remarkably inhibited migration and invasion of pancreatic cancer cells. Further studies indicated that MRG …
C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer.
Yamaguchi K, Sakai M, Shimokawa T, Yamada Y, Nakamura Y, Furukawa Y. Yamaguchi K, et al. Br J Cancer. 2010 Jan 19;102(2):325-31. doi: 10.1038/sj.bjc.6605500. Epub 2010 Jan 5. Br J Cancer. 2010. PMID: 20051959 Free PMC article.
MRGBP marginally expressed in normal vital organs. Notably, suppressed MRGBP expression by MRGBP short hairpin RNA inhibited proliferation of colorectal cancer cells. ...CONCLUSION: These results suggest that MRGBP has an important function in prolifer …
MRGBP marginally expressed in normal vital organs. Notably, suppressed MRGBP expression by MRGBP short hairpin RNA inhi …
MRG-binding protein contributes to colorectal cancer development.
Yamaguchi K, Sakai M, Kim J, Tsunesumi S, Fujii T, Ikenoue T, Yamada Y, Akiyama Y, Muto Y, Yamaguchi R, Miyano S, Nakamura Y, Furukawa Y. Yamaguchi K, et al. Cancer Sci. 2011 Aug;102(8):1486-92. doi: 10.1111/j.1349-7006.2011.01971.x. Epub 2011 Jun 9. Cancer Sci. 2011. PMID: 21535316 Free PMC article.
We previously showed that MRGBP was upregulated in the majority of colorectal tumors, and the enhanced expression was associated with cell proliferation. ...Theses results suggest that MRGBP contributes to colorectal carcinogenesis through rendering advantages in ce …
We previously showed that MRGBP was upregulated in the majority of colorectal tumors, and the enhanced expression was associated with …
30 results