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MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer.
Xu H, Zou R, Li F, Liu J, Luan N, Wang S, Zhu L. Xu H, et al. Cancer Med. 2021 Jun;10(11):3655-3673. doi: 10.1002/cam4.3907. Epub 2021 May 2. Cancer Med. 2021. PMID: 33934540 Free PMC article.
METHODS: Using STRING database and MCODE plugin in Cytoscape, six MRPs were identified among genes that are upregulated in response to HE4 overexpression in epithelial ovarian cancer cells. The Cancer Genome Atlas (TCGA) ovarian cancer, GTEX, Oncomine, and TI …
METHODS: Using STRING database and MCODE plugin in Cytoscape, six MRPs were identified among genes that are upregulated in response to HE4 o …
MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness.
Min S, Lee YK, Hong J, Park TJ, Woo HG, Kwon SM, Yoon G. Min S, et al. Cell Death Dis. 2021 Nov 12;12(11):1076. doi: 10.1038/s41419-021-04370-8. Cell Death Dis. 2021. PMID: 34772924 Free PMC article.
Association analysis between the genomic and transcriptomic profiles of 82 MRPs using The Cancer Genome Atlas-Liver HCC database identified eight key SCNA-dependent MRPs: MRPS31, MRPL10, MRPL21, MRPL15, MRPL13, MRPL55, and DAP3. MRPS31 was the only downregula …
Association analysis between the genomic and transcriptomic profiles of 82 MRPs using The Cancer Genome Atlas-Liver HCC database iden …
Expression and affinity purification of recombinant mammalian mitochondrial ribosomal small subunit (MRPS) proteins and protein-protein interaction analysis indicate putative role in tumourigenic cellular processes.
Revathi Paramasivam O, Gopisetty G, Subramani J, Thangarajan R. Revathi Paramasivam O, et al. J Biochem. 2021 Sep 7;169(6):675-692. doi: 10.1093/jb/mvab004. J Biochem. 2021. PMID: 34492114
The PPI network analysis revealed putative role in cellular processes with implications for tumourigenesis. Gene expression screening of a cancer cell line panel indicated overexpression of MRPS10 and MRPS31 in breast cancer. Co-expression module identificati …
The PPI network analysis revealed putative role in cellular processes with implications for tumourigenesis. Gene expression screening of a …
NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells.
Savas S, Azorsa DO, Jarjanazi H, Ibrahim-Zada I, Gonzales IM, Arora S, Henderson MC, Choi YH, Briollais L, Ozcelik H, Tuzmen S. Savas S, et al. PLoS One. 2011 Apr 4;6(4):e18306. doi: 10.1371/journal.pone.0018306. PLoS One. 2011. PMID: 21483694 Free PMC article.
After correction of the p-values for multiple testing using False Discovery Rate, our results identified three genes (NRP1, COL13A1, MRPS31) and six genes (EAF2, ANK2, AKAP7, STEAP2, LPIN2, PARVB) associated with resistance to simvastatin and lovastatin, respectively. ...O …
After correction of the p-values for multiple testing using False Discovery Rate, our results identified three genes (NRP1, COL13A1, MRPS …
Transcriptome and Gene Fusion Analysis of Synchronous Lesions Reveals lncMRPS31P5 as a Novel Transcript Involved in Colorectal Cancer.
Panza A, Castellana S, Biscaglia G, Piepoli A, Parca L, Gentile A, Latiano A, Mazza T, Perri F, Andriulli A, Palmieri O. Panza A, et al. Int J Mol Sci. 2020 Sep 27;21(19):7120. doi: 10.3390/ijms21197120. Int J Mol Sci. 2020. PMID: 32992457 Free PMC article.
., miRNAs and long non-coding RNAs) constitute essential pieces of the puzzle of the tumor genomic landscape, in particular in mechanisms behind the adenoma-to-carcinoma progression of colorectal cancer (CRC). In this work, we aimed to identify molecular signatures of the …
., miRNAs and long non-coding RNAs) constitute essential pieces of the puzzle of the tumor genomic landscape, in particular in mechanisms be …
Zinc finger C3H1 domain-containing protein (ZFC3H1) evaluates the prognosis and treatment of prostate adenocarcinoma (PRAD): A study based on TCGA data.
Huang H, Xu H, Li P, Ye X, Chen W, Chen W, Huang X. Huang H, et al. Bioengineered. 2021 Dec;12(1):5504-5515. doi: 10.1080/21655979.2021.1965442. Bioengineered. 2021. PMID: 34514952 Free PMC article.
The present study was aimed to evaluate the expression profile of Zinc finger C3H1 domain-containing protein (ZFC3H1) using bioinformatic analysis of public datasets from The Cancer Genome Atlas database (TCGA). The results showed that the expression levels of ZFC3H1 were …
The present study was aimed to evaluate the expression profile of Zinc finger C3H1 domain-containing protein (ZFC3H1) using bioinformatic an …
Identification of thyroid carcinoma related genes with mRMR and shortest path approaches.
Xu Y, Deng Y, Ji Z, Liu H, Liu Y, Peng H, Wu J, Fan J. Xu Y, et al. PLoS One. 2014 Apr 9;9(4):e94022. doi: 10.1371/journal.pone.0094022. eCollection 2014. PLoS One. 2014. PMID: 24718460 Free PMC article.
Thyroid cancer is a malignant neoplasm originated from thyroid cells. It can be classified into papillary carcinomas (PTCs) and anaplastic carcinomas (ATCs). ...Our results may provide insights to the molecular mechanism of the progression of thyroid cancer....
Thyroid cancer is a malignant neoplasm originated from thyroid cells. It can be classified into papillary carcinomas (PTCs) and anapl …
Identification and Validation of a Novel RNA-Binding Protein-Related Gene-Based Prognostic Model for Multiple Myeloma.
Wang W, Xu SW, Zhu XY, Guo QY, Zhu M, Mao XL, Chen YH, Li SW, Luo WD. Wang W, et al. Front Genet. 2021 Apr 26;12:665173. doi: 10.3389/fgene.2021.665173. eCollection 2021. Front Genet. 2021. PMID: 33981333 Free PMC article.
METHOD: After screening the differentially expressed RBPs, univariate Cox regression was performed to evaluate the prognostic relevance of each gene using The Cancer Genome Atlas (TCGA)-Multiple Myeloma Research Foundation (MMRF) dataset. ...The signature includes eight hu …
METHOD: After screening the differentially expressed RBPs, univariate Cox regression was performed to evaluate the prognostic relevance of e …