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2003 1
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190 results

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LncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability.
Zhu Y, Zhou B, Hu X, Ying S, Zhou Q, Xu W, Feng L, Hou T, Wang X, Zhu L, Jin H. Zhu Y, et al. Clin Transl Med. 2022 Jan;12(1):e703. doi: 10.1002/ctm2.703. Clin Transl Med. 2022. PMID: 35073459 Free PMC article.
Co-immunoprecipitation and ubiquitination assays were performed to explore the molecular mechanisms of the Musashi2 (MSI2) post-modification. The effects of LINC00942 (LNC942) and MSI2 on DDP-based chemotherapy were investigated through MTS, apoptosis assays and xen …
Co-immunoprecipitation and ubiquitination assays were performed to explore the molecular mechanisms of the Musashi2 (MSI2) post-modif …
Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia.
Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, Tayyari F, McSkimming D, Kannan N, Tojo A, Edison AS, Ito T. Hattori A, et al. Nature. 2017 May 25;545(7655):500-504. doi: 10.1038/nature22314. Epub 2017 May 17. Nature. 2017. PMID: 28514443 Free PMC article.
Reprogrammed cellular metabolism is a common characteristic observed in various cancers. However, whether metabolic changes directly regulate cancer development and progression remains poorly understood. ...Taken together, this work reveals that altered BCAA metabol …
Reprogrammed cellular metabolism is a common characteristic observed in various cancers. However, whether metabolic changes directly …
Single-cell mapping identifies MSI(+) cells as a common origin for diverse subtypes of pancreatic cancer.
Rajbhandari N, Hamilton M, Quintero CM, Ferguson LP, Fox R, Schürch CM, Wang J, Nakamura M, Lytle NK, McDermott M, Diaz E, Pettit H, Kritzik M, Han H, Cridebring D, Wen KW, Tsai S, Goggins MG, Lowy AM, Wechsler-Reya RJ, Von Hoff DD, Newman AM, Reya T. Rajbhandari N, et al. Cancer Cell. 2023 Nov 13;41(11):1989-2005.e9. doi: 10.1016/j.ccell.2023.09.008. Epub 2023 Oct 5. Cancer Cell. 2023. PMID: 37802055
To determine whether stem/progenitor cells can serve as cells of origin, we created a Msi2-Cre(ERT2) knock-in mouse. When crossed to CAG-LSL-Myc(T58A) mice, Msi2-Cre(ERT2) mice developed multiple pancreatic cancer subtypes: ductal, acinar, adenosquamous, and …
To determine whether stem/progenitor cells can serve as cells of origin, we created a Msi2-Cre(ERT2) knock-in mouse. When crossed to …
RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7.
Zou H, Luo J, Guo Y, Liu Y, Wang Y, Deng L, Li P. Zou H, et al. Oncogene. 2022 Mar;41(11):1657-1672. doi: 10.1038/s41388-022-02198-w. Epub 2022 Jan 31. Oncogene. 2022. PMID: 35102250 Free PMC article.
Here, we revealed that Hippo signaling effector YAP1 functioned as a key downstream regulator of LIN28 to modulate the cancer stem cell (CSC)-like properties and tumor progressions in triple negative breast cancer (TNBC). ...Accordingly, co-upregulations of LIN28 an …
Here, we revealed that Hippo signaling effector YAP1 functioned as a key downstream regulator of LIN28 to modulate the cancer stem ce …
MicroRNA-143/Musashi-2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer.
Tsujino T, Sugito N, Taniguchi K, Honda R, Komura K, Yoshikawa Y, Takai T, Minami K, Kuranaga Y, Shinohara H, Tokumaru Y, Heishima K, Inamoto T, Azuma H, Akao Y. Tsujino T, et al. Cancer Sci. 2019 Jul;110(7):2189-2199. doi: 10.1111/cas.14035. Epub 2019 May 27. Cancer Sci. 2019. PMID: 31066120 Free PMC article.
We have previously shown that miR-143 suppresses cell growth by inhibiting RAS signaling networks in several cancers including BC. In the present study, we showed that synthetic miR-143 negatively regulated the RNA-binding protein Musashi-2 (MSI2) in BC cell lines. …
We have previously shown that miR-143 suppresses cell growth by inhibiting RAS signaling networks in several cancers including BC. In …
Musashi-2 (MSI2) regulation of DNA damage response in lung cancer.
Bychkov I, Deneka A, Topchu I, Pangeni RP, Lengner C, Karanicolas J, Golemis EA, Makhov P, Boumber Y. Bychkov I, et al. bioRxiv [Preprint]. 2023 Jun 14:2023.06.13.544756. doi: 10.1101/2023.06.13.544756. bioRxiv. 2023. PMID: 37398283 Free PMC article. Preprint.
Lung cancer is one of the most common types of cancers worldwide. Non-small cell lung cancer (NSCLC), typically caused by KRAS and TP53 driver mutations, represents the majority of all new lung cancer diagnoses. ...This adds the knowledge of MSI2 …
Lung cancer is one of the most common types of cancers worldwide. Non-small cell lung cancer (NSCLC), typically caused …
Prognostic value of Musashi 2 (MSI2) in cancer patients: A systematic review and meta-analysis.
Jiang L, Xue S, Xu J, Fu X, Wei J, Zhang C. Jiang L, et al. Front Oncol. 2022 Dec 1;12:969632. doi: 10.3389/fonc.2022.969632. eCollection 2022. Front Oncol. 2022. PMID: 36530989 Free PMC article.
Musashi 2 (MSI2) is an RNA-binding protein that regulates mRNA translation of numerous intracellular targets and plays an important role in the development of cancer. ...In conclusion, elevated MSI2 expression is closely correlated with poor prognosis in vari …
Musashi 2 (MSI2) is an RNA-binding protein that regulates mRNA translation of numerous intracellular targets and plays an important r …
MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota.
Li N, Xu S, Zhang S, Zhu Q, Meng X, An W, Fu B, Zhong M, Yang Y, Lin Z, Liu X, Xia J, Wang J, You T, Yan C, Tang H, Zhuang G, Peng Z. Li N, et al. Front Immunol. 2023 Jan 12;13:963379. doi: 10.3389/fimmu.2022.963379. eCollection 2022. Front Immunol. 2023. PMID: 36713428 Free PMC article.
METHODS: Msi2(flox/flox) mice (Msi2(fl/fl) ) and Msi2(flox/flox)Rorc(Cre) mice (Msi2(deltaRorc) ) were induced by DSS to establish the IBD model. ...The species, quantity and function of the intestinal microbiota were characterized by high-throughput 1 …
METHODS: Msi2(flox/flox) mice (Msi2(fl/fl) ) and Msi2(flox/flox)Rorc(Cre) mice (Msi2(deltaRorc) ) were induced b …
ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
Kim HS, Na MJ, Son KH, Yang HD, Kim SY, Shin E, Ha JW, Jeon S, Kang K, Moon K, Park WS, Nam SW. Kim HS, et al. Exp Mol Med. 2023 Jan;55(1):95-107. doi: 10.1038/s12276-022-00916-8. Epub 2023 Jan 4. Exp Mol Med. 2023. PMID: 36599932 Free PMC article.
We then demonstrated that Musashi RNA-binding protein 2 (MSI2) was a specific target of miR-3144-3p and that MSI2 overexpression was due to excessive ADAR1-dependent over-editing of canonical miR-3144-3p in liver cancer. ...The ectopic expression of both ADAR …
We then demonstrated that Musashi RNA-binding protein 2 (MSI2) was a specific target of miR-3144-3p and that MSI2 overexpressi …
The Novel KLF4/MSI2 Signaling Pathway Regulates Growth and Metastasis of Pancreatic Cancer.
Guo K, Cui J, Quan M, Xie D, Jia Z, Wei D, Wang L, Gao Y, Ma Q, Xie K. Guo K, et al. Clin Cancer Res. 2017 Feb 1;23(3):687-696. doi: 10.1158/1078-0432.CCR-16-1064. Epub 2016 Jul 22. Clin Cancer Res. 2017. PMID: 27449499 Free PMC article.
The biological functions of MSI2 regarding PDAC cell growth, migration, invasion, and metastasis were studied using gain- and loss-of-function assays both in vitro and in vivo Regulation of MSI2 expression by KLF4 was examined in several cancer cell lines, an …
The biological functions of MSI2 regarding PDAC cell growth, migration, invasion, and metastasis were studied using gain- and loss-of …
190 results