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Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes.
Fan Q, Li H, Wang X, Tham YC, Teo KYC, Yasuda M, Lim WK, Kwan YP, Teo JX, Chen CJ, Chen LJ, Ahn J, Davila S, Miyake M, Tan P, Park KH, Pang CP, Khor CC, Wong TY, Yanagi Y, Cheung CMG, Cheng CY. Fan Q, et al. Nat Commun. 2023 Sep 11;14(1):5574. doi: 10.1038/s41467-023-41256-z. Nat Commun. 2023. PMID: 37696869 Free PMC article.
At the GATA binding protein 5 (GATA5) locus, the most significant GWAS novel loci, the expressions of genes including laminin subunit alpha 5 (Lama5), mitochondrial ribosome associated GTPase 2 (Mtg2), and collagen type IX alpha 3 chain (Col9A3), are significantly induced …
At the GATA binding protein 5 (GATA5) locus, the most significant GWAS novel loci, the expressions of genes including laminin subunit alpha …
A global transcriptional network connecting noncoding mutations to changes in tumor gene expression.
Zhang W, Bojorquez-Gomez A, Velez DO, Xu G, Sanchez KS, Shen JP, Chen K, Licon K, Melton C, Olson KM, Yu MK, Huang JK, Carter H, Farley EK, Snyder M, Fraley SI, Kreisberg JF, Ideker T. Zhang W, et al. Nat Genet. 2018 Apr;50(4):613-620. doi: 10.1038/s41588-018-0091-2. Epub 2018 Apr 2. Nat Genet. 2018. PMID: 29610481 Free PMC article.
Although cancer genomes are replete with noncoding mutations, the effects of these mutations remain poorly characterized. ...Among these, we find that the effects of noncoding mutations on DAAM1, MTG2 and HYI transcription are recapitulated in multiple cancer …
Although cancer genomes are replete with noncoding mutations, the effects of these mutations remain poorly characterized. ...Among th …
Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTEN.
Wang Y, Ande SR, Mishra S. Wang Y, et al. BMC Cancer. 2012 Jul 3;12:277. doi: 10.1186/1471-2407-12-277. BMC Cancer. 2012. PMID: 22759359 Free PMC article.
BACKGROUND: Transglutaminase 2 (TG2) and its phosphorylation have been consistently found to be upregulated in a number of cancer cell types. At the molecular level, TG2 has been associated with the activation of nuclear factor-kappa B (NF-kappaB), protein kinase B (PKB/Ak …
BACKGROUND: Transglutaminase 2 (TG2) and its phosphorylation have been consistently found to be upregulated in a number of cancer cel …