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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 2
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1995 1
1996 1
1997 5
1998 4
1999 20
2000 27
2001 37
2002 39
2003 53
2004 75
2005 95
2006 102
2007 116
2008 135
2009 110
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1,965 results

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Page 1
Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks.
Raghubeer S, Matsha TE. Raghubeer S, et al. Nutrients. 2021 Dec 20;13(12):4562. doi: 10.3390/nu13124562. Nutrients. 2021. PMID: 34960114 Free PMC article. Review.
The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular homeostasis due to its key functions in the one-carbon cycle, which include methionine and folate metabolism and protein, DNA, and RNA synthesis. The enzyme is responsible for m …
The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular homeostasis due to its key functions …
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.
Liew SC, Gupta ED. Liew SC, et al. Eur J Med Genet. 2015 Jan;58(1):1-10. doi: 10.1016/j.ejmg.2014.10.004. Epub 2014 Nov 4. Eur J Med Genet. 2015. PMID: 25449138 Review.
The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) with the epidemiology of the polymorphism of the C677T that varies dependent on the geograph …
The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with various diseases (vascular, ca …
MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.
Petrone I, Bernardo PS, Dos Santos EC, Abdelhay E. Petrone I, et al. Genes (Basel). 2021 Apr 17;12(4):587. doi: 10.3390/genes12040587. Genes (Basel). 2021. PMID: 33920562 Free PMC article. Review.
MTHFR polymorphisms have been linked to increased risks of several pathologies, including cancer. ...This review discusses the relationship between the MTHFR C677T and A1298C polymorphisms and the increased risk of breast cancer, gliomas, and gastric …
MTHFR polymorphisms have been linked to increased risks of several pathologies, including cancer. ...This review discusses the …
Role of the MTHFR polymorphisms in cancer risk modification and treatment.
Kim YI. Kim YI. Future Oncol. 2009 May;5(4):523-42. doi: 10.2217/fon.09.26. Future Oncol. 2009. PMID: 19450180 Review.
Furthermore, studies suggest that MTHFR inhibition may be a potential target for increasing chemosensitvity of cancer cells to 5FU-based chemotherapy. Because the MTHFR SNPs are prevalent and MTX and 5FU are widely used for the treatment of common cancers …
Furthermore, studies suggest that MTHFR inhibition may be a potential target for increasing chemosensitvity of cancer cells to …
The association between MTHFR polymorphisms and cervical cancer risk: a system review and meta analysis.
Yi K, Yang L, Lan Z, Xi M. Yi K, et al. Arch Gynecol Obstet. 2016 Sep;294(3):579-88. doi: 10.1007/s00404-016-4037-6. Epub 2016 Feb 15. Arch Gynecol Obstet. 2016. PMID: 26879954 Review.
PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) plays an important role in determining the proportions of folate coenzymes for DNA synthesis or DNA methylation. ...CONCLUSIONS: This study indicated that the MTHFR C677T may be no associated with ce …
PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) plays an important role in determining the proportions of folate c …
MTHFR c.665C>T guided fluoropyrimidine therapy in cancer: gender-dependent effect on dose requirements.
Ioannou C, Ragia G, Balgkouranidou I, Xenidis N, Amarantidis K, Koukaki T, Biziota E, Kakolyris S, Manolopoulos VG. Ioannou C, et al. Drug Metab Pers Ther. 2022 Mar 11;37(3):323-327. doi: 10.1515/dmpt-2021-0219. eCollection 2022 Sep 1. Drug Metab Pers Ther. 2022. PMID: 35272420 Free article.
METHODS: The study group consisted of 313 fluoropyrimidine-treated cancer patients. PCR-RFLP was used to analyze MTHFR c.665C>T polymorphism. ...Such differences were not present in male patients. No other associations were found. CONCLUSIONS: MTHFR c.665C …
METHODS: The study group consisted of 313 fluoropyrimidine-treated cancer patients. PCR-RFLP was used to analyze MTHFR c.665C& …
A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk.
Izmirli M. Izmirli M. Mol Biol Rep. 2013 Jan;40(1):625-37. doi: 10.1007/s11033-012-2101-2. Epub 2012 Oct 19. Mol Biol Rep. 2013. PMID: 23076526 Review.
5,10-Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate metabolism. ...The literature review included all published relevant cancer types and MTHFR polymorphisms for that 5 years period. All selected polymorphism …
5,10-Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate metabolism. ...The literature …
Association between MTHFR gene polymorphism and the risk of ovarian cancer: a meta-analysis of the literature.
Pu D, Jiang SW, Wu J. Pu D, et al. Curr Pharm Des. 2014;20(11):1632-8. doi: 10.2174/13816128113199990564. Curr Pharm Des. 2014. PMID: 24720627 Review.
OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme for DNA biosynthesis and the epigenetic process of DNA methylation. MTHFR gene polymorphisms have been implicated as risk factors for several types of cancers. ...
OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme for DNA biosynthesis and the epigenetic …
Cumulative review and meta-analyses on the association between MTHFR rs1801133 polymorphism and breast cancer risk: a pooled analysis of 83 studies with 74,019 participants.
Zhang Y, Jia H, Wang S, Jiang D. Zhang Y, et al. Minerva Med. 2017 Feb;108(1):57-73. doi: 10.23736/S0026-4806.16.04759-5. Epub 2016 Nov 8. Minerva Med. 2017. PMID: 27824246 Review.
BACKGROUND: The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast cancer risk has been extensively explored, but their results are conflicting rather than conclusive. To clarify the precise effects of MTHF …
BACKGROUND: The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast cancer …
The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis.
Mei Q, Zhou D, Gao J, Shen S, Wu J, Guo L, Liang Z. Mei Q, et al. BMC Cancer. 2012 Oct 11;12:467. doi: 10.1186/1471-2407-12-467. BMC Cancer. 2012. PMID: 23057736 Free PMC article. Review.
BACKGROUND: MTHFR 677C>T polymorphism is a genetic alteration in an enzyme involved in folate metabolism, but its effect on host susceptibility to cervical cancer is still uncertain. The aim of this study was to investigate the association between MTHFR 67 …
BACKGROUND: MTHFR 677C>T polymorphism is a genetic alteration in an enzyme involved in folate metabolism, but its effect on host s …
1,965 results