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Year Number of Results
1992 1
1994 3
1995 3
1996 5
1997 3
1998 5
1999 6
2000 14
2001 15
2002 7
2003 6
2004 23
2005 16
2006 23
2007 29
2008 20
2009 17
2010 28
2011 32
2012 30
2013 41
2014 52
2015 46
2016 35
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2024 21

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752 results

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Page 1
The role of membrane mucin MUC4 in breast cancer metastasis.
Dreyer CA, VanderVorst K, Free S, Rowson-Hodel A, Carraway KL. Dreyer CA, et al. Endocr Relat Cancer. 2021 Nov 24;29(1):R17-R32. doi: 10.1530/ERC-21-0083. Endocr Relat Cancer. 2021. PMID: 34726614 Free PMC article. Review.
Analysis of a genetically engineered mouse model of HER2-positive breast cancer has demonstrated that metastatic efficiency is markedly suppressed with Muc4 deletion and Muc4-knockout tumor cells are poorly associated with platelets and white blood cells know …
Analysis of a genetically engineered mouse model of HER2-positive breast cancer has demonstrated that metastatic efficiency is marked …
MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy.
Gautam SK, Kumar S, Dam V, Ghersi D, Jain M, Batra SK. Gautam SK, et al. Semin Immunol. 2020 Feb;47:101391. doi: 10.1016/j.smim.2020.101391. Epub 2020 Jan 14. Semin Immunol. 2020. PMID: 31952903 Free PMC article. Review.
Existence of PC-associated MUC4 splice variants, autoantibodies against overexpressed and aberrantly glycosylated MUC4 and presence of T-cell clones against the mutations present in MUC4 further reinforce its significance as a tumor antigen for vaccine develo …
Existence of PC-associated MUC4 splice variants, autoantibodies against overexpressed and aberrantly glycosylated MUC4 and pre …
Muc4/MUC4 functions and regulation in cancer.
Carraway KL, Theodoropoulos G, Kozloski GA, Carothers Carraway CA. Carraway KL, et al. Future Oncol. 2009 Dec;5(10):1631-40. doi: 10.2217/fon.09.125. Future Oncol. 2009. PMID: 20001800 Free PMC article. Review.
Muc4/MUC4 can also modulate cell apoptosis via multiple mechanisms, both ErbB2 dependent and independent. Muc4/MUC4 expression is regulated by multiple mechanisms, ranging from transcriptional to post-translational. ...
Muc4/MUC4 can also modulate cell apoptosis via multiple mechanisms, both ErbB2 dependent and independent. Muc4/MUC4 …
Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy.
Singh AP, Chaturvedi P, Batra SK. Singh AP, et al. Cancer Res. 2007 Jan 15;67(2):433-6. doi: 10.1158/0008-5472.CAN-06-3114. Cancer Res. 2007. PMID: 17234748 Review.
The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosi …
The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly e …
Integrative Analysis of MUC4 to Prognosis and Immune Infiltration in Pan-Cancer: Friend or Foe?
Gao XP, Dong JJ, Xie T, Guan X. Gao XP, et al. Front Cell Dev Biol. 2021 Jul 16;9:695544. doi: 10.3389/fcell.2021.695544. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34336844 Free PMC article.
Recent studies suggest that MUC4 has been implicated in pancreatic cancer pathogenesis and is expressed in various normal and cancer tissues. ...However, the contributions of MUC4 to pan-cancer have not been well characterized. In this study, we …
Recent studies suggest that MUC4 has been implicated in pancreatic cancer pathogenesis and is expressed in various normal and …
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive.
Carraway KL, Perez A, Idris N, Jepson S, Arango M, Komatsu M, Haq B, Price-Schiavi SA, Zhang J, Carraway CA. Carraway KL, et al. Prog Nucleic Acid Res Mol Biol. 2002;71:149-85. doi: 10.1016/s0079-6603(02)71043-x. Prog Nucleic Acid Res Mol Biol. 2002. PMID: 12102554 Review.
Muc4 expression is regulated in epithelial tissues in a cell- and tissue-specific manner during epithelial differentiation. In stratified epithelia, it is predominantly in the most superficial, differentiated layers, often coincident with ErbB2. Dysregulation of Muc4 …
Muc4 expression is regulated in epithelial tissues in a cell- and tissue-specific manner during epithelial differentiation. In strati …
Blocking soluble TNFalpha sensitizes HER2-positive breast cancer to trastuzumab through MUC4 downregulation and subverts immunosuppression.
Bruni S, Mauro FL, Proietti CJ, Cordo-Russo RI, Rivas MA, Inurrigarro G, Dupont A, Rocha D, Fernández EA, Deza EG, Lopez Della Vecchia D, Barchuk S, Figurelli S, Lasso D, Friedrich AD, Santilli MC, Regge MV, Lebersztein G, Levit C, Anfuso F, Castiglione T, Elizalde PV, Mercogliano MF, Schillaci R. Bruni S, et al. J Immunother Cancer. 2023 Mar;11(3):e005325. doi: 10.1136/jitc-2022-005325. J Immunother Cancer. 2023. PMID: 36889811 Free PMC article.
Here, we used mouse models and samples from HER2+ breast cancer patients to unravel MUC4 participation in hindering trastuzumab effect by fostering immune evasion. ...In addition, tumor cells treated with DN are more susceptible to trastuzumab-dependent cellular pha …
Here, we used mouse models and samples from HER2+ breast cancer patients to unravel MUC4 participation in hindering trastuzuma …
Muc4/sialomucin complex in the mammary gland and breast cancer.
Carraway KL, Price-Schiavi SA, Komatsu M, Jepson S, Perez A, Carraway CA. Carraway KL, et al. J Mammary Gland Biol Neoplasia. 2001 Jul;6(3):323-37. doi: 10.1023/a:1011327708973. J Mammary Gland Biol Neoplasia. 2001. PMID: 11547901 Review.
Expression of MUC4 in mammary gland is repressed by posttranscriptional mechanisms involving basement membrane and TGF-beta, which are relieved during pregnancy to permit secretion of MUC4 into milk. ...These observations imply important functions for MUC4 in …
Expression of MUC4 in mammary gland is repressed by posttranscriptional mechanisms involving basement membrane and TGF-beta, which ar …
MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans.
Sagar S, Leiphrakpam PD, Thomas D, McAndrews KL, Caffrey TC, Swanson BJ, Clausen H, Wandall HH, Hollingsworth MA, Radhakrishnan P. Sagar S, et al. Cancer Lett. 2021 Apr 10;503:91-102. doi: 10.1016/j.canlet.2021.01.015. Epub 2021 Jan 22. Cancer Lett. 2021. PMID: 33485947 Free PMC article.
Tn-MUC4 specific 3B11 antibody inhibited MUC4-induced ErbB receptor and its downstream signaling cascades. ...Additionally, MUC4(KO) cells were found to be more sensitive to gemcitabine treatment. ...
Tn-MUC4 specific 3B11 antibody inhibited MUC4-induced ErbB receptor and its downstream signaling cascades. ...Additionally, …
Pancreatic cancer counterattack: MUC4 mediates Fas-independent apoptosis of antigen-specific cytotoxic T lymphocyte.
Zhu Y, Zhang JJ, Liang WB, Zhu R, Wang B, Miao Y, Xu ZK. Zhu Y, et al. Oncol Rep. 2014 Apr;31(4):1768-76. doi: 10.3892/or.2014.3016. Epub 2014 Feb 10. Oncol Rep. 2014. PMID: 24534824
Tumor-associated MUC4 mucin has considerable potential as an immunotherapy target for pancreatic cancer. ...First, the adverse influence of regulatory T cells (Tregs) was eliminated by CD8+ T lymphocyte sorting before the induction of MS-CTLs. Then, we constructed c …
Tumor-associated MUC4 mucin has considerable potential as an immunotherapy target for pancreatic cancer. ...First, the adverse …
752 results