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1988 3
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1998 1
1999 2
2000 1
2001 1
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2004 1
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99 results

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MYC, MYCL, and MYCN as therapeutic targets in lung cancer.
Massó-Vallés D, Beaulieu ME, Soucek L. Massó-Vallés D, et al. Expert Opin Ther Targets. 2020 Feb;24(2):101-114. doi: 10.1080/14728222.2020.1723548. Epub 2020 Feb 13. Expert Opin Ther Targets. 2020. PMID: 32003251 Review.
Introduction: Lung cancer is the leading cause of cancer-related mortality globally. Despite recent advances with personalized therapies and immunotherapy, the prognosis remains dire and recurrence is frequent. Myc is an oncogene deregulated in human cancers, …
Introduction: Lung cancer is the leading cause of cancer-related mortality globally. Despite recent advances with personalized …
MYCL promotes the progression of triple-negative breast cancer by activating the JAK/STAT3 pathway.
Jiang H, Li X, Wang W, Hu Y, Ren D. Jiang H, et al. Oncol Rep. 2022 Nov;48(5):203. doi: 10.3892/or.2022.8418. Epub 2022 Sep 30. Oncol Rep. 2022. PMID: 36177900 Free PMC article.
The present study aimed to investigate the underlying regulatory mechanism of MYCL proto-oncogene (MYCL) in triple-negative breast cancer (TNBC) progression. ...Notably, MYCL could activate the JAK/STAT3 pathway, whereas inhibition of the JAK/STAT3 pat …
The present study aimed to investigate the underlying regulatory mechanism of MYCL proto-oncogene (MYCL) in triple-negative br …
Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer.
Ciampricotti M, Karakousi T, Richards AL, Quintanal-Villalonga À, Karatza A, Caeser R, Costa EA, Allaj V, Manoj P, Spainhower KB, Kombak FE, Sanchez-Rivera FJ, Jaspers JE, Zavitsanou AM, Maddalo D, Ventura A, Rideout WM, Akama-Garren EH, Jacks T, Donoghue MTA, Sen T, Oliver TG, Poirier JT, Papagiannakopoulos T, Rudin CM. Ciampricotti M, et al. Cancer Discov. 2021 Dec 1;11(12):3214-3229. doi: 10.1158/2159-8290.CD-21-0441. Cancer Discov. 2021. PMID: 34344693 Free PMC article.
Tumors from the RLF-MYCL genetically engineered mouse model displayed gene expression similarities with human RLF-MYCL SCLC. ...SIGNIFICANCE: The biological and therapeutic implications of gene fusions in SCLC, an aggressive metastatic lung cancer, are unknow …
Tumors from the RLF-MYCL genetically engineered mouse model displayed gene expression similarities with human RLF-MYCL SCLC. . …
Alternative approaches to target Myc for cancer treatment.
Wang C, Zhang J, Yin J, Gan Y, Xu S, Gu Y, Huang W. Wang C, et al. Signal Transduct Target Ther. 2021 Mar 10;6(1):117. doi: 10.1038/s41392-021-00500-y. Signal Transduct Target Ther. 2021. PMID: 33692331 Free PMC article. Review.
The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively. ...In this review, after a comprehensive summarization of valuable sources for potential druggable …
The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereaft …
MYCL genotypes and loss of heterozygosity in non-small-cell lung cancer.
Fong KM, Kida Y, Zimmerman PV, Smith PJ. Fong KM, et al. Br J Cancer. 1996 Dec;74(12):1975-8. doi: 10.1038/bjc.1996.662. Br J Cancer. 1996. PMID: 8980399 Free PMC article.
Some studies have suggested that the S allele of the MYCL oncogene, which results from an intragenic EcoRI restriction fragment length polymorphism (RFLP), may be associated with cancer susceptibility. ...We studied 108 cases of surgical resected non-small-cell lung …
Some studies have suggested that the S allele of the MYCL oncogene, which results from an intragenic EcoRI restriction fragment lengt …
Demystifying the Druggability of the MYC Family of Oncogenes.
Karadkhelkar NM, Lin M, Eubanks LM, Janda KD. Karadkhelkar NM, et al. J Am Chem Soc. 2023 Feb 15;145(6):3259-3269. doi: 10.1021/jacs.2c12732. Epub 2023 Feb 3. J Am Chem Soc. 2023. PMID: 36734615 Free PMC article. Review.
Translationally, MYC is one of the foremost oncogenic targets, and deregulation of expression of the MYC family gene/proteins occurs in over half of all human tumors and is recognized as a hallmark of cancer initiation and maintenance. Additionally, unexpected roles for th …
Translationally, MYC is one of the foremost oncogenic targets, and deregulation of expression of the MYC family gene/proteins occurs in over …
The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.
Anderson DA 3rd, Murphy TL, Eisenman RN, Murphy KM. Anderson DA 3rd, et al. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4885-4893. doi: 10.1073/pnas.1915060117. Epub 2020 Feb 18. Proc Natl Acad Sci U S A. 2020. PMID: 32071205 Free PMC article.
Here we observed that Mycl is expressed in immature cDC1s but repressed on maturation, concomitant with Mxd1 induction in mature cDC1s. We hypothesized that MYCL and MXD1 regulate a shared, but reciprocal, transcriptional program during cDC1 maturation. ...
Here we observed that Mycl is expressed in immature cDC1s but repressed on maturation, concomitant with Mxd1 induction in mature cDC1 …
c-MYC-Driven Polyamine Metabolism in Ovarian Cancer: From Pathogenesis to Early Detection and Therapy.
Chen Y, León-Letelier RA, Abdel Sater AH, Vykoukal J, Dennison JB, Hanash S, Fahrmann JF. Chen Y, et al. Cancers (Basel). 2023 Jan 19;15(3):623. doi: 10.3390/cancers15030623. Cancers (Basel). 2023. PMID: 36765581 Free PMC article. Review.
c-MYC and its paralogues MYCN and MYCL are among the most frequently amplified and/or overexpressed oncoproteins in ovarian cancer. c-MYC plays a key role in promoting ovarian cancer initiation and progression. ...Targeting of the polyamine pathway via small …
c-MYC and its paralogues MYCN and MYCL are among the most frequently amplified and/or overexpressed oncoproteins in ovarian cancer …
A Novel Synthetic Lethal Approach to Target MYC-Driven Cancers.
Chabanon RM, Postel-Vinay S. Chabanon RM, et al. Cancer Res. 2022 Mar 15;82(6):969-971. doi: 10.1158/0008-5472.CAN-22-0302. Cancer Res. 2022. PMID: 35288735
The MYC proto-oncogene family encompasses three related transcription factors (MYC, MYCL, and MYCN), which are master regulators of cellular programs orchestrating multiple hallmarks of cancer, including proliferation, metabolism, invasiveness, and immune surveillan …
The MYC proto-oncogene family encompasses three related transcription factors (MYC, MYCL, and MYCN), which are master regulators of c …
99 results