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Year Number of Results
1990 1
1994 1
1996 1
1998 1
2000 3
2001 2
2002 8
2003 13
2004 14
2005 15
2006 24
2007 39
2008 33
2009 46
2010 63
2011 75
2012 79
2013 125
2014 167
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2019 199
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2,264 results

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MyD88 mediates colorectal cancer cell proliferation, migration and invasion via NF-kappaB/AP-1 signaling pathway.
Zhu G, Cheng Z, Huang Y, Zheng W, Yang S, Lin C, Ye J. Zhu G, et al. Int J Mol Med. 2020 Jan;45(1):131-140. doi: 10.3892/ijmm.2019.4390. Epub 2019 Oct 31. Int J Mol Med. 2020. PMID: 31746347 Free PMC article.
We found that knockdown of the MyD88 gene can affect proliferation, invasion, and migration of colorectal cancer cells. ...These results show that MyD88 gene plays an important role in promoting colorectal cancer, and thus can be exploited as a potenti …
We found that knockdown of the MyD88 gene can affect proliferation, invasion, and migration of colorectal cancer cells. ...The …
MYD88 L265P Mutation in Lymphoid Malignancies.
Yu X, Li W, Deng Q, Li L, Hsi ED, Young KH, Zhang M, Li Y. Yu X, et al. Cancer Res. 2018 May 15;78(10):2457-2462. doi: 10.1158/0008-5472.CAN-18-0215. Epub 2018 Apr 27. Cancer Res. 2018. PMID: 29703722 Review.
Few cancers such as WM have a single amino acid substitution in one gene like MYD88 L265P that occurs in 90% of cases, making WM paradigmatic for study of a single causative mutation in oncogenesis. In this review, we summarize the frequency and cancer spectr …
Few cancers such as WM have a single amino acid substitution in one gene like MYD88 L265P that occurs in 90% of cases, making …
Xiao-Chai-Hu-Tang ameliorates tumor growth in cancer comorbid depressive symptoms via modulating gut microbiota-mediated TLR4/MyD88/NF-kappaB signaling pathway.
Shao S, Jia R, Zhao L, Zhang Y, Guan Y, Wen H, Liu J, Zhao Y, Feng Y, Zhang Z, Ji Q, Li Q, Wang Y. Shao S, et al. Phytomedicine. 2021 Jul 15;88:153606. doi: 10.1016/j.phymed.2021.153606. Epub 2021 May 24. Phytomedicine. 2021. PMID: 34111616 Free article. Clinical Trial.
BACKGROUND: Depressive symptoms are thought to promote cancer development and depressive remission has been reported to be effective for defeating cancer. ...This study implies a novel clinical significance of anti-depressive herbal medicine in the cancer tre …
BACKGROUND: Depressive symptoms are thought to promote cancer development and depressive remission has been reported to be effective …
Contribution of drugs acting on the TLRs/MyD88 signaling pathway on colitis-associated cancer.
Zhu M, Yu K, Wang L, Yu S. Zhu M, et al. Pharmazie. 2018 Jul 1;73(7):363-368. doi: 10.1691/ph.2018.8388. Pharmazie. 2018. PMID: 30001768 Review.
The conclusion of studies about the role of TLRs/MyD88 signaling in colon cancer remains contradictory: on one hand, TLRs/MyD88 signaling contributes to colon tumor cell proliferation, invasion and metastasis and inhibition of the expression of TLRs or MyD …
The conclusion of studies about the role of TLRs/MyD88 signaling in colon cancer remains contradictory: on one hand, TLRs/M …
The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori.
Liu M, Hu Z, Wang C, Zhang Y. Liu M, et al. J Mol Med (Berl). 2023 Jul;101(7):767-781. doi: 10.1007/s00109-023-02332-5. Epub 2023 May 17. J Mol Med (Berl). 2023. PMID: 37195446 Review.
H. pylori can influence host cell signalling pathways to induce gastric disease development and mediate cancer promotion and progression. Toll-like receptors (TLRs), as pattern recognition receptors (PRRs), play a key role in the gastrointestinal innate immune response, an …
H. pylori can influence host cell signalling pathways to induce gastric disease development and mediate cancer promotion and progress …
Dual functional roles of the MyD88 signaling in colorectal cancer development.
Wang L, Yu K, Zhang X, Yu S. Wang L, et al. Biomed Pharmacother. 2018 Nov;107:177-184. doi: 10.1016/j.biopha.2018.07.139. Epub 2018 Aug 4. Biomed Pharmacother. 2018. PMID: 30086464 Review.
Detection of MyD88 expression was to predict prognosis of various human cancers, e.g., lymphoid, liver, and colorectal cancers. In human cancers, MyD88 protein acts as a bridge between the inflammatory signaling from the TLR/IL-1R and Ras oncoge …
Detection of MyD88 expression was to predict prognosis of various human cancers, e.g., lymphoid, liver, and colorectal canc …
MyD88 and Its Inhibitors in Cancer: Prospects and Challenges.
Song J, Li Y, Wu K, Hu Y, Fang L. Song J, et al. Biomolecules. 2024 May 7;14(5):562. doi: 10.3390/biom14050562. Biomolecules. 2024. PMID: 38785969 Free PMC article. Review.
Therefore, MyD88 could serve as a novel tumor biomarker and is a promising target for cancer therapy. ...Therefore, this review describes the involvement of MyD88 in tumor immune escape and disease therapy. In addition, classical and non-classical MyD88 …
Therefore, MyD88 could serve as a novel tumor biomarker and is a promising target for cancer therapy. ...Therefore, this revie …
Immunological differences between primary and metastatic breast cancer.
Szekely B, Bossuyt V, Li X, Wali VB, Patwardhan GA, Frederick C, Silber A, Park T, Harigopal M, Pelekanou V, Zhang M, Yan Q, Rimm DL, Bianchini G, Hatzis C, Pusztai L. Szekely B, et al. Ann Oncol. 2018 Nov 1;29(11):2232-2239. doi: 10.1093/annonc/mdy399. Ann Oncol. 2018. PMID: 30203045 Free article.
BACKGROUND: Little is known about how the immune microenvironment of breast cancer evolves during disease progression. PATIENTS AND METHODS: We compared tumor infiltrating lymphocyte (TIL) count, programmed death-ligand 1 (PD-L1) protein expression by immunohistochemistry …
BACKGROUND: Little is known about how the immune microenvironment of breast cancer evolves during disease progression. PATIENTS AND M …
Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin.
Zheng JH, Nguyen VH, Jiang SN, Park SH, Tan W, Hong SH, Shin MG, Chung IJ, Hong Y, Bom HS, Choy HE, Lee SE, Rhee JH, Min JJ. Zheng JH, et al. Sci Transl Med. 2017 Feb 8;9(376):eaak9537. doi: 10.1126/scitranslmed.aak9537. Sci Transl Med. 2017. PMID: 28179508
We report a method of cancer immunotherapy using an attenuated Salmonella typhimurium strain engineered to secrete Vibrio vulnificus flagellin B (FlaB) in tumor tissues. ...Together, these findings provide evidence that nonvirulent tumor-targeting bacteria releasing multip …
We report a method of cancer immunotherapy using an attenuated Salmonella typhimurium strain engineered to secrete Vibrio vulnificus …
MyD88 signalling is critical in the development of pancreatic cancer cachexia.
Zhu X, Burfeind KG, Michaelis KA, Braun TP, Olson B, Pelz KR, Morgan TK, Marks DL. Zhu X, et al. J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):378-390. doi: 10.1002/jcsm.12377. Epub 2019 Jan 21. J Cachexia Sarcopenia Muscle. 2019. PMID: 30666818 Free PMC article.
In this study, we tested whether MyD88 signalling is essential in the development of pancreatic cancer cachexia using a robust mouse tumour model. ...CONCLUSIONS: MyD88-dependent inflammation is crucial in the pathophysiology of pancreatic cancer progr …
In this study, we tested whether MyD88 signalling is essential in the development of pancreatic cancer cachexia using a robust …
2,264 results