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Page 1
Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism.
Han L, Huang D, Wu S, Liu S, Wang C, Sheng Y, Lu X, Broxmeyer HE, Wan J, Yang L. Han L, et al. Nat Cell Biol. 2023 Jul;25(7):1033-1046. doi: 10.1038/s41556-023-01162-4. Epub 2023 Jun 1. Nat Cell Biol. 2023. PMID: 37264180 Free PMC article.
LIPTER binds phosphatidic acid and phosphatidylinositol 4-phosphate on LD surface membranes and the MYH10 protein, connecting LDs to the MYH10-ACTIN cytoskeleton and facilitating LD transport. ...Our findings unveil a molecular connector role of LIPTER in intramyocy …
LIPTER binds phosphatidic acid and phosphatidylinositol 4-phosphate on LD surface membranes and the MYH10 protein, connecting LDs to …
Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.
Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR. Kim HT, et al. Nat Commun. 2018 Nov 2;9(1):4600. doi: 10.1038/s41467-018-06833-7. Nat Commun. 2018. PMID: 30389913 Free PMC article.
In a forward genetic screen for modulators of mouse lung development, we identified the non-muscle myosin II heavy chain gene, Myh10. Myh10 mutant pups exhibit cyanosis and respiratory distress, and die shortly after birth from differentiation defects in alveolar ep …
In a forward genetic screen for modulators of mouse lung development, we identified the non-muscle myosin II heavy chain gene, Myh10. …
A point mutation in Myh10 causes major defects in heart development and body wall closure.
Ma X, Adelstein RS. Ma X, et al. Circ Cardiovasc Genet. 2014 Jun;7(3):257-65. doi: 10.1161/CIRCGENETICS.113.000455. Epub 2014 May 13. Circ Cardiovasc Genet. 2014. PMID: 24825879 Free PMC article.
Previous work, using knockout and hypomorphic mice, showed that Myh10 encoding myosin heavy chain II-B is critical for cardiac and brain development. ...
Previous work, using knockout and hypomorphic mice, showed that Myh10 encoding myosin heavy chain II-B is critical for cardiac and br …
Generation of heterozygous (MRli003-A-1) and homozygous (MRli003-A-2) MYH10 knockout human iPSC lines.
Zhang F, Meier AB, Laugwitz KL, Dorn T, Moretti A. Zhang F, et al. Stem Cell Res. 2021 Dec;57:102612. doi: 10.1016/j.scr.2021.102612. Epub 2021 Nov 29. Stem Cell Res. 2021. PMID: 34864222 Free article.
Myosin-10, also known as non-muscle myosin IIB, is a cytoskeletal protein implicated in cardiac development and disease. In humans, it is encoded by the MYH10 gene. Using CRISPR/Cas9 gene editing technology, we generated two MYH10 knockout human iPSC lines - one het …
Myosin-10, also known as non-muscle myosin IIB, is a cytoskeletal protein implicated in cardiac development and disease. In humans, it is en …
Transcription factor defects causing platelet disorders.
Daly ME. Daly ME. Blood Rev. 2017 Jan;31(1):1-10. doi: 10.1016/j.blre.2016.07.002. Epub 2016 Jul 16. Blood Rev. 2017. PMID: 27450272 Free article. Review.
Some of the transcription factor defects are also associated with an increased predisposition to haematologic malignancies (RUNX1, ETV6), abnormal erythropoiesis (GATA-1, GFI1b, ETV6) and immune dysfunction (FLI1). The persistence of MYH10 expression in platelets is a surr …
Some of the transcription factor defects are also associated with an increased predisposition to haematologic malignancies (RUNX1, ETV6), ab …
Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.
Arrigo AB, Lin JI. Arrigo AB, et al. Int J Mol Sci. 2021 Aug 16;22(16):8816. doi: 10.3390/ijms22168816. Int J Mol Sci. 2021. PMID: 34445520 Free PMC article. Review.
Although there is no impact on CNCCs in Lrp2 mutants, the loss of LRP2 results in the depletion of sonic hedgehog (SHH)-dependent cells in the second heart field. SHH is known to be crucial for CNCC survival and proliferation, which suggests LRP2 has a non-autonomous role …
Although there is no impact on CNCCs in Lrp2 mutants, the loss of LRP2 results in the depletion of sonic hedgehog (SHH)-dependent cells in t …
Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development.
Huang Y, Wang X, Wang X, Xu M, Liu M, Liu D. Huang Y, et al. Gene Expr Patterns. 2013 Oct;13(7):265-70. doi: 10.1016/j.gep.2013.04.005. Epub 2013 May 9. Gene Expr Patterns. 2013. PMID: 23665442
The three NM II isoforms share a very similar molecular structure and play important roles in a variety of fundamental biological processes. NM II-B (myh10) has been shown to be essential for the formation of mouse neural system and heart. ...It was maintained and e …
The three NM II isoforms share a very similar molecular structure and play important roles in a variety of fundamental biological processes. …
Proteomic study of Tianxiangdan intervention in rats with myocardial ischemia.
Zhao MF, Sun LF, Xie XL, An DQ. Zhao MF, et al. J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.13. Epub 2022 Sep 29. J Physiol Pharmacol. 2022. PMID: 36193969 Free article.
Combined with the references, tropomyosin alpha-3 chain (TPM3), protein kinase C delta (PRKCD), myosin heavy chain 10 (MYH10), MYH6, G protein subunit alpha i2 (GNAI2), and other proteins were screened out. ...We conclude that Tianxiangdan could improve myocardial ischemia …
Combined with the references, tropomyosin alpha-3 chain (TPM3), protein kinase C delta (PRKCD), myosin heavy chain 10 (MYH10), MYH6, …
Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta.
Kiema M, Sarin JK, Kauhanen SP, Torniainen J, Matikka H, Luoto ES, Jaakkola P, Saari P, Liimatainen T, Vanninen R, Ylä-Herttuala S, Hedman M, Laakkonen JP. Kiema M, et al. Front Physiol. 2022 Jul 7;13:934941. doi: 10.3389/fphys.2022.934941. eCollection 2022. Front Physiol. 2022. PMID: 35874533 Free PMC article.
Failure values were shown to correlate with smooth muscle cell (SMC) density (rho = -0.45, p < 0.02), and indicated the more MYH10(+) SMCs the lower the strength of the aortic wall structure. ...

Failure values were shown to correlate with smooth muscle cell (SMC) density (rho = -0.45, p < 0.02), and indicated the more MYH10

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Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development.
Ridge LA, Mitchell K, Al-Anbaki A, Shaikh Qureshi WM, Stephen LA, Tenin G, Lu Y, Lupu IE, Clowes C, Robertson A, Barnes E, Wright JA, Keavney B, Ehler E, Lovell SC, Kadler KE, Hentges KE. Ridge LA, et al. PLoS Genet. 2017 Oct 30;13(10):e1007068. doi: 10.1371/journal.pgen.1007068. eCollection 2017 Oct. PLoS Genet. 2017. PMID: 29084269 Free PMC article.
The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow contribute to cardiac disease, a major cause of premature death worldwide. ...Positional cloning and candidate gene analysis revealed that th …
The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow c …
32 results