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CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms.
Ji M, Su L, Liu L, Zhuang M, Xiao J, Guan Y, Zhu S, Ma L, Pu H. Ji M, et al. Sci Rep. 2023 Apr 10;13(1):5827. doi: 10.1038/s41598-023-32941-6. Sci Rep. 2023. PMID: 37037889 Free PMC article.
Although opioids are necessary for the treatment of acute pain, cancer pain, and palliative care, opioid abuse is a serious threat to society. ...Here, we demonstrate that diacetylmorphine induces abnormal electrocardiographic changes in rats and causes damage to cardiomyo …
Although opioids are necessary for the treatment of acute pain, cancer pain, and palliative care, opioid abuse is a serious threat to …
Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients.
Yuan X, Yu T, Zhao J, Jiang H, Hao Y, Lei W, Liang Y, Li B, Qian W. Yuan X, et al. Front Med. 2023 Oct;17(5):889-906. doi: 10.1007/s11684-023-0994-x. Epub 2023 Jul 7. Front Med. 2023. PMID: 37418076
A total of 263 genes mutated in coding regions were identified, including 6 newly discovered genes (ROBO2, KMT2C, CXCR4, MYOM2, BCLAF1, and NRXN3) detected in 10% of the cases. CD79B mutation was significantly associated with lower PFS, TMSB4X mutation and high expression …
A total of 263 genes mutated in coding regions were identified, including 6 newly discovered genes (ROBO2, KMT2C, CXCR4, MYOM2, BCLAF …
Reduced Zeb1 Expression in Prostate Cancer Cells Leads to an Aggressive Partial-EMT Phenotype Associated with Altered Global Methylation Patterns.
Kitz J, Lefebvre C, Carlos J, Lowes LE, Allan AL. Kitz J, et al. Int J Mol Sci. 2021 Nov 27;22(23):12840. doi: 10.3390/ijms222312840. Int J Mol Sci. 2021. PMID: 34884649 Free PMC article.
Prostate cancer is the most common cancer in American men and the second leading cause of cancer-related death. ...DNA methylation chip analysis revealed 10 potential targets for identifying and/or targeting aggressive p-EMT prostate cancer in the futu …
Prostate cancer is the most common cancer in American men and the second leading cause of cancer-related death. ...DNA …
Identification of a novel PDGFRA point mutation at p.P6L as a potential molecular target of imatinib in an eosinophilia patient showing genetic heterogeneity.
Zhao M, Wu Q, Xia L, Zhang M, Yang J, Li Y, Tu S, Wang Y. Zhao M, et al. Cancer Biol Ther. 2019;20(4):402-407. doi: 10.1080/15384047.2018.1532558. Epub 2018 Oct 25. Cancer Biol Ther. 2019. PMID: 30359545 Free PMC article.
Using next generation sequencing (NGS), we detected point mutations in PDGFRA, MYOM2, and ASXL3. The patient then received imatinib therapy, leading to the complete disappearance of FIP1L1-PDGFRA fusion gene and mutated MYOM2. ...
Using next generation sequencing (NGS), we detected point mutations in PDGFRA, MYOM2, and ASXL3. The patient then received imatinib t …
Identification of genes that exhibit changes in expression on the 8p chromosomal arm by the Systematic Multiplex RT-PCR (SM RT-PCR) and DNA microarray hybridization methods.
Yamamoto F, Yamamoto M. Yamamoto F, et al. Gene Expr. 2008;14(4):217-27. doi: 10.3727/105221608786883816. Gene Expr. 2008. PMID: 19110721 Free PMC article.
Losses of the p-arm of chromosome 8 are frequently observed in breast, prostate, and other types of cancers. Using the Systematic Multiplex RT-PCR (SM RT-PCR) method and the DNA microarray hybridization method, we examined the expression of 273 genes located on the p-arm o …
Losses of the p-arm of chromosome 8 are frequently observed in breast, prostate, and other types of cancers. Using the Systematic Mul …
Diffuse large B-cell lymphoma and red cell autoimmunity: clinical role and pathogenesis.
Coombes C, Horikawa K, Jain S, Jiang S, Lim JH, Saxena K, Shadbolt B, Smyth L, Tobin J, Talaulikar D. Coombes C, et al. Pathology. 2023 Feb;55(1):104-112. doi: 10.1016/j.pathol.2022.07.017. Epub 2022 Oct 7. Pathology. 2023. PMID: 36420560
The most frequently mutated genes in 15 patient samples were KMT2D (n=13), MYOM2 (n=9), EP300 (n=8), SPEN (n=7), and ADAMTSL3 (n=7), which were mutated in both DAT+ and DAT- groups. ...
The most frequently mutated genes in 15 patient samples were KMT2D (n=13), MYOM2 (n=9), EP300 (n=8), SPEN (n=7), and ADAMTSL3 (n=7), …
A three-gene signature based on tumour microenvironment predicts overall survival of osteosarcoma in adolescents and young adults.
Wen C, Wang H, Wang H, Mo H, Zhong W, Tang J, Lu Y, Zhou W, Tan A, Liu Y, Xie W. Wen C, et al. Aging (Albany NY). 2020 Dec 3;13(1):619-645. doi: 10.18632/aging.202170. Epub 2020 Dec 3. Aging (Albany NY). 2020. PMID: 33281116 Free PMC article.
The differentially expressed genes (DEGs) between the two groups were analyzed and 122 DEGs were revealed. Finally, three genes (COCH, MYOM2 and PDE1B) with the minimum AIC value were derived from 122 DEGs by multivariate cox analysis. ...
The differentially expressed genes (DEGs) between the two groups were analyzed and 122 DEGs were revealed. Finally, three genes (COCH, MY …
Transcriptional Expression in Human Periodontal Ligament Cells Subjected to Orthodontic Force: An RNA-Sequencing Study.
Kim K, Kang HE, Yook JI, Yu HS, Kim E, Cha JY, Choi YJ. Kim K, et al. J Clin Med. 2020 Jan 28;9(2):358. doi: 10.3390/jcm9020358. J Clin Med. 2020. PMID: 32012982 Free PMC article.
Real-time PCR results confirmed that five upregulated genes (CC2D1B, CPNE3, OPHN1, TANGO2, and UAP-1) and six downregulated genes (MYOM2, PPM1F, PCDP1, ATP2A1, GPR171, and RP1-34H18.1-1) were consistent with RNA sequencing results. ...
Real-time PCR results confirmed that five upregulated genes (CC2D1B, CPNE3, OPHN1, TANGO2, and UAP-1) and six downregulated genes (MYOM2 …