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Year Number of Results
2007 2
2011 4
2012 1
2013 3
2014 3
2015 8
2016 8
2017 9
2018 6
2019 4
2020 7
2021 11
2022 4
2023 6
2024 6

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74 results

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Page 1
Human hematopoietic stem cell vulnerability to ferroptosis.
Zhao J, Jia Y, Mahmut D, Deik AA, Jeanfavre S, Clish CB, Sankaran VG. Zhao J, et al. Cell. 2023 Feb 16;186(4):732-747.e16. doi: 10.1016/j.cell.2023.01.020. Cell. 2023. PMID: 36803603 Free PMC article.
Here, inspired by a bone marrow failure disorder due to the loss of the histone deubiquitinase MYSM1, characterized by selectively disadvantaged HSCs, we show how reduced protein synthesis in HSCs results in increased ferroptosis. ...Importantly, this selective vulnerabili …
Here, inspired by a bone marrow failure disorder due to the loss of the histone deubiquitinase MYSM1, characterized by selectively di …
Genetic and Pharmacological Inhibition of Astrocytic Mysm1 Alleviates Depressive-Like Disorders by Promoting ATP Production.
Zhang H, Liu S, Qin Q, Xu Z, Qu Y, Wang Y, Wang J, Du Z, Yuan S, Hong S, Chang Z, He W, Yan X, Lang Y, Tang R, Wang Y, Zhu L, Jiang X. Zhang H, et al. Adv Sci (Weinh). 2022 Nov 22;10(1):e2204463. doi: 10.1002/advs.202204463. Online ahead of print. Adv Sci (Weinh). 2022. PMID: 36414403 Free PMC article.
Pifithrin alpha (PFT alpha) and Compound C, antagonists of p53 and AMPK, respectively, repressed ATP production and reversed the antidepressant effect of Mysm1 knockdown. Moreover, the pharmacological inhibition of astrocytic Mysm1 by aspirin relieved depressive-lik …
Pifithrin alpha (PFT alpha) and Compound C, antagonists of p53 and AMPK, respectively, repressed ATP production and reversed the antidepress …
MYSM1 induces apoptosis and sensitizes TNBC cells to cisplatin via RSK3-phospho-BAD pathway.
Guan X, Meng X, Zhu K, Kai J, Liu Y, Ma Q, Tong Y, Zheng H, Xie S, Ma X, Wang Y, Lu R, Guo L. Guan X, et al. Cell Death Discov. 2022 Feb 26;8(1):84. doi: 10.1038/s41420-022-00881-1. Cell Death Discov. 2022. PMID: 35217648 Free PMC article.
This study demonstrated the function of Myb-like, SWIRM, and MPN domains 1 (MYSM1), an H2A deubiquitinase (DUB), in TNBC. MYSM1 expression was drastically decreased in breast cancer, especially in TNBC, suggesting a potential anticancer effect. Overexpressing and su …
This study demonstrated the function of Myb-like, SWIRM, and MPN domains 1 (MYSM1), an H2A deubiquitinase (DUB), in TNBC. MYSM1 …
Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression.
Xu Z, Qin Q, Wang Y, Zhang H, Liu S, Li X, Chen Y, Wang Y, Ruan H, He W, Zhang T, Yan X, Wang C, Xu D, Jiang X. Xu Z, et al. Cell Death Dis. 2024 Feb 12;15(2):129. doi: 10.1038/s41419-024-06530-y. Cell Death Dis. 2024. PMID: 38342917 Free PMC article.
It is unknown whether Mysm1 plays an important role in NSCs. Here, we found that Mysm1 was expressed in NSCs and its expression was increased with age in mice. Mice with Mysm1 knockdown by crossing Mysm1 floxed mice with Nestin-Cre mice exhibited abnor …
It is unknown whether Mysm1 plays an important role in NSCs. Here, we found that Mysm1 was expressed in NSCs and its expressio …
Deubiquitinase MYSM1 in the Hematopoietic System and beyond: A Current Review.
Fiore A, Liang Y, Lin YH, Tung J, Wang H, Langlais D, Nijnik A. Fiore A, et al. Int J Mol Sci. 2020 Apr 24;21(8):3007. doi: 10.3390/ijms21083007. Int J Mol Sci. 2020. PMID: 32344625 Free PMC article. Review.
The functions of MYSM1 in different cell types and aspects of mammalian physiology are also reviewed, highlighting the key checkpoints in hematopoiesis, immunity, and beyond regulated by MYSM1. ...Our growing knowledge of MYSM1 functions and mechanisms of act …
The functions of MYSM1 in different cell types and aspects of mammalian physiology are also reviewed, highlighting the key checkpoint …
MYSM1 acts as a novel co-activator of ERalpha to confer antiestrogen resistance in breast cancer.
Luan R, He M, Li H, Bai Y, Wang A, Sun G, Zhou B, Wang M, Wang C, Wang S, Zeng K, Feng J, Lin L, Wei Y, Kato S, Zhang Q, Zhao Y. Luan R, et al. EMBO Mol Med. 2024 Jan;16(1):10-39. doi: 10.1038/s44321-023-00003-z. Epub 2023 Dec 15. EMBO Mol Med. 2024. PMID: 38177530 Free PMC article.
MYSM1 is involved in maintenance of ERalpha stability via ERalpha deubiquitination. ...MYSM1 is highly expressed in clinical BCa samples. MYSM1 depletion attenuates BCa-derived cell growth in xenograft models and increases the sensitivity of antiestrogen agen …
MYSM1 is involved in maintenance of ERalpha stability via ERalpha deubiquitination. ...MYSM1 is highly expressed in clinical B …
MYSM1-AR complex-mediated repression of Akt/c-Raf/GSK-3beta signaling impedes castration-resistant prostate cancer growth.
Sun J, Hu X, Gao Y, Tang Q, Zhao Z, Xi W, Yang F, Zhang W, Song Y, Song B, Wang T, Wang H. Sun J, et al. Aging (Albany NY). 2019 Nov 24;11(22):10644-10663. doi: 10.18632/aging.102482. Epub 2019 Nov 24. Aging (Albany NY). 2019. PMID: 31761786 Free PMC article.
Integrative bioinformatic analyses of the significantly associated genes with MYSM1 revealed MYSM1-correlated pathways, providing substantial clues as to the role of MYSM1 in PCa. MYSM1 was able to bind to androgen receptor instead of increasing its ex …
Integrative bioinformatic analyses of the significantly associated genes with MYSM1 revealed MYSM1-correlated pathways, provid …
MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway.
Tian M, Liu W, Zhang Q, Huang Y, Li W, Wang W, Zhao P, Huang S, Song Y, Shereen MA, Qin M, Liu Y, Wu K, Wu J. Tian M, et al. Cell Rep. 2020 Oct 20;33(3):108297. doi: 10.1016/j.celrep.2020.108297. Cell Rep. 2020. PMID: 33086059 Free article.
MYSM1 subsequently interacts with STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling. ...Importantly, MYSM1 treatment represses the production of IFNs and pro-inflammatory cytokines in the PBMCs of SLE patients. ...
MYSM1 subsequently interacts with STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling. ...Importantly, …
Loss of p53 compensates osteopenia in murine Mysm1 deficiency.
Haffner-Luntzer M, Kovtun A, Fischer V, Prystaz K, Hainzl A, Kroeger CM, Krikki I, Brinker TJ, Ignatius A, Gatzka M. Haffner-Luntzer M, et al. FASEB J. 2018 Apr;32(4):1957-1968. doi: 10.1096/fj.201700871R. Epub 2018 Jan 5. FASEB J. 2018. PMID: 29203593
Osteogenic differentiation of Mysm1(-/-) MSCs, however, was not compromised in vitro. In line with defective hematopoietic development of Mysm1-deficient mice, Mysm1(-/-) osteoclasts had reduced resorption activity and were more prone to apoptosis in TUNEL as …
Osteogenic differentiation of Mysm1(-/-) MSCs, however, was not compromised in vitro. In line with defective hematopoietic developmen …
Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.
Liang Y, Bhatt G, Tung LT, Wang H, Kim JE, Mousa M, Plackoska V, Illes K, Georges AA, Gros P, Henneman L, Huijbers IJ, Nagar B, Nijnik A. Liang Y, et al. Sci Rep. 2023 Jan 7;13(1):338. doi: 10.1038/s41598-023-27486-7. Sci Rep. 2023. PMID: 36611064 Free PMC article.
To test this, here we generated a new mouse strain carrying a Mysm1(D660N) point mutation (Mysm1(DN)) and demonstrated that the mutation renders MYSM1 protein catalytically inactive. We characterized Mysm1(DN/DN) and Mysm1(fl/DN) Cre(ERT2) mice, …
To test this, here we generated a new mouse strain carrying a Mysm1(D660N) point mutation (Mysm1(DN)) and demonstrated that th …
74 results