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Histone acetyltransferase CBP promotes function of SCF FBXL19 ubiquitin E3 ligase by acetylation and stabilization of its F-box protein subunit.
Wei J, Dong S, Yao K, Martinez MFYM, Fleisher PR, Zhao Y, Ma H, Zhao J. Wei J, et al. Among authors: ma h. FASEB J. 2018 Aug;32(8):4284-4292. doi: 10.1096/fj.201701069R. Epub 2018 Mar 9. FASEB J. 2018. PMID: 29522376 Free PMC article.
Here we show that FBXL19 degradation is controlled by the balance between its ubiquitination and acetylation. FBXL19 is an unstable protein with a half-life of 3 h. FBXL19 can be polyubiquitinated, and the proteasome inhibitor MG-132 prolongs FBXL19 half-life, suggesting t …
Here we show that FBXL19 degradation is controlled by the balance between its ubiquitination and acetylation. FBXL19 is an unstable protein …
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