Histone acetyltransferase CBP promotes function of SCF FBXL19 ubiquitin E3 ligase by acetylation and stabilization of its F-box protein subunit.
Wei J, Dong S, Yao K, Martinez MFYM, Fleisher PR, Zhao Y, Ma H, Zhao J.
Wei J, et al. Among authors: ma h.
FASEB J. 2018 Aug;32(8):4284-4292. doi: 10.1096/fj.201701069R. Epub 2018 Mar 9.
FASEB J. 2018.
PMID: 29522376
Free PMC article.
Here we show that FBXL19 degradation is controlled by the balance between its ubiquitination and acetylation. FBXL19 is an unstable protein with a half-life of 3 h. FBXL19 can be polyubiquitinated, and the proteasome inhibitor MG-132 prolongs FBXL19 half-life, suggesting t …
Here we show that FBXL19 degradation is controlled by the balance between its ubiquitination and acetylation. FBXL19 is an unstable protein …