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Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.
Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, Cesare AJ, Gibberman A, Wang X, O'Neill FA, Walsh D, Kendler KS. Straub RE, et al. Among authors: ma y. Am J Hum Genet. 2002 Aug;71(2):337-48. doi: 10.1086/341750. Epub 2002 Jul 3. Am J Hum Genet. 2002. PMID: 12098102 Free PMC article.
A schizophrenia locus may be located in region 10p15-p11.
Straub RE, MacLean CJ, Martin RB, Ma Y, Myakishev MV, Harris-Kerr C, Webb BT, O'Neill FA, Walsh D, Kendler KS. Straub RE, et al. Among authors: ma y. Am J Med Genet. 1998 Jul 10;81(4):296-301. doi: 10.1002/(sici)1096-8628(19980710)81:4<296::aid-ajmg4>3.0.co;2-s. Am J Med Genet. 1998. PMID: 9674974
Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes.
Straub RE, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, O'Neill FA, Walsh D, Kendler KS. Straub RE, et al. Among authors: ma y. Mol Psychiatry. 2002;7(6):542-59. doi: 10.1038/sj.mp.4001051. Mol Psychiatry. 2002. PMID: 12140777
Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study.
Straub RE, Sullivan PF, Ma Y, Myakishev MV, Harris-Kerr C, Wormley B, Kadambi B, Sadek H, Silverman MA, Webb BT, Neale MC, Bulik CM, Joyce PR, Kendler KS. Straub RE, et al. Among authors: ma y. Mol Psychiatry. 1999 Mar;4(2):129-44. doi: 10.1038/sj.mp.4000518. Mol Psychiatry. 1999. PMID: 10208445
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