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MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET.
Srivastava A, Tommasi C, Sessions D, Mah A, Bencomo T, Garcia JM, Jiang T, Lee M, Shen JY, Seow LW, Nguyen A, Rajapakshe K, Coarfa C, Tsai KY, Lopez-Pajares V, Lee CS. Srivastava A, et al. Cancer Res. 2022 Sep 2;82(17):3143-3157. doi: 10.1158/0008-5472.CAN-22-0047. Cancer Res. 2022. PMID: 35705526 Free PMC article.
Loss of MAB21L4 in human cSCC organoids increased expression of RET to enable malignant progression. In addition to transcriptional upregulation of RET, deletion of MAB21L4 preempted recruitment of the CacyBP-Siah1 E3 ligase complex to RET and reduced its ubiquityla …
Loss of MAB21L4 in human cSCC organoids increased expression of RET to enable malignant progression. In addition to transcriptional u …
MAB21L4 regulates the TGF-beta-induced expression of target genes in epidermal keratinocytes.
Ogami T, Tamura Y, Toss K, Yuki K, Morikawa M, Tsutsumi S, Aburatani H, Miyazawa K, Miyazono K, Koinuma D. Ogami T, et al. J Biochem. 2022 Mar 31;171(4):399-410. doi: 10.1093/jb/mvab141. J Biochem. 2022. PMID: 34908107 Free PMC article.
Transcriptional activity of the IVL promoter induced by TGF-beta was inhibited by MAB21L4 siRNAs. Further analysis revealed that MAB21L4 siRNAs also down-regulated the expression of several target genes of TGF-beta. MAB21L4 protein was located mainly in the c …
Transcriptional activity of the IVL promoter induced by TGF-beta was inhibited by MAB21L4 siRNAs. Further analysis revealed that M …