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An additional spirocyclization for duocarmycin SA.
MacMillan KS, Boger DL. MacMillan KS, et al. J Am Chem Soc. 2008 Dec 10;130(49):16521-3. doi: 10.1021/ja806593w. J Am Chem Soc. 2008. PMID: 19554689 Free PMC article.
Synthesis and evaluation of a thio analogue of duocarmycin SA.
MacMillan KS, Lajiness JP, Cara CL, Romagnoli R, Robertson WM, Hwang I, Baraldi PG, Boger DL. MacMillan KS, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. doi: 10.1016/j.bmcl.2009.10.063. Epub 2009 Oct 17. Bioorg Med Chem Lett. 2009. PMID: 19879753 Free PMC article.
Synthesis and Preliminary Evaluation of Duocarmycin Analogues Incorporating the 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[2,3-e]indol-4-one (CNI) and 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[1,2-e]indol-4-one (iso-CNI) Alkylation Subunits.
Gauss CM, Hamasaki A, Parrish JP, Macmillan KS, Rayl TJ, Hwang I, Boger DL. Gauss CM, et al. Among authors: macmillan ks. Tetrahedron. 2009 Aug 15;65(33):6591-6599. doi: 10.1016/j.tet.2009.02.065. Tetrahedron. 2009. PMID: 20161204 Free PMC article.
Development of proneurogenic, neuroprotective small molecules.
MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM. MacMillan KS, et al. J Am Chem Soc. 2011 Feb 9;133(5):1428-37. doi: 10.1021/ja108211m. Epub 2011 Jan 6. J Am Chem Soc. 2011. PMID: 21210688 Free PMC article.
Potent cytotoxic C-11 modified geldanamycin analogues.
Tian ZQ, Wang Z, MacMillan KS, Zhou Y, Carreras CW, Mueller T, Myles DC, Liu Y. Tian ZQ, et al. Among authors: macmillan ks. J Med Chem. 2009 May 28;52(10):3265-73. doi: 10.1021/jm900098v. J Med Chem. 2009. PMID: 19405528
16 results