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Long-term safety and tolerability of ambrisentan treatment for pediatric patients with pulmonary arterial hypertension: An open-label extension study.
Ivy D, Beghetti M, Juaneda-Simian E, Ravindranath R, Lukas MA, Machlitt-Northen S, Scott N, Narita J, Berger RMF. Ivy D, et al. Among authors: machlitt northen s. Eur J Pediatr. 2024 May;183(5):2141-2153. doi: 10.1007/s00431-024-05446-1. Epub 2024 Feb 16. Eur J Pediatr. 2024. PMID: 38366267 Free PMC article. Clinical Trial.
Letter to the Editor, regarding Li L, Zhu X, Chen X, Gao J, Ding C, et al. Advances in targeted therapy for pulmonary arterial hypertension in children. Eur J Pediatr. 2022 Dec 17.
Beghetti M, Ivy D, Scott N, Machlitt-Northen S, Lukas MA. Beghetti M, et al. Among authors: machlitt northen s. Eur J Pediatr. 2023 May;182(5):2453-2454. doi: 10.1007/s00431-023-04877-6. Epub 2023 Feb 27. Eur J Pediatr. 2023. PMID: 36847876 Free PMC article. No abstract available.
The next-generation Open Targets Platform: reimagined, redesigned, rebuilt.
Ochoa D, Hercules A, Carmona M, Suveges D, Baker J, Malangone C, Lopez I, Miranda A, Cruz-Castillo C, Fumis L, Bernal-Llinares M, Tsukanov K, Cornu H, Tsirigos K, Razuvayevskaya O, Buniello A, Schwartzentruber J, Karim M, Ariano B, Martinez Osorio RE, Ferrer J, Ge X, Machlitt-Northen S, Gonzalez-Uriarte A, Saha S, Tirunagari S, Mehta C, Roldán-Romero JM, Horswell S, Young S, Ghoussaini M, Hulcoop DG, Dunham I, McDonagh EM. Ochoa D, et al. Among authors: machlitt northen s. Nucleic Acids Res. 2023 Jan 6;51(D1):D1353-D1359. doi: 10.1093/nar/gkac1046. Nucleic Acids Res. 2023. PMID: 36399499 Free PMC article.
Open Targets Platform: supporting systematic drug-target identification and prioritisation.
Ochoa D, Hercules A, Carmona M, Suveges D, Gonzalez-Uriarte A, Malangone C, Miranda A, Fumis L, Carvalho-Silva D, Spitzer M, Baker J, Ferrer J, Raies A, Razuvayevskaya O, Faulconbridge A, Petsalaki E, Mutowo P, Machlitt-Northen S, Peat G, McAuley E, Ong CK, Mountjoy E, Ghoussaini M, Pierleoni A, Papa E, Pignatelli M, Koscielny G, Karim M, Schwartzentruber J, Hulcoop DG, Dunham I, McDonagh EM. Ochoa D, et al. Among authors: machlitt northen s. Nucleic Acids Res. 2021 Jan 8;49(D1):D1302-D1310. doi: 10.1093/nar/gkaa1027. Nucleic Acids Res. 2021. PMID: 33196847 Free PMC article.
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.
Ghoussaini M, Mountjoy E, Carmona M, Peat G, Schmidt EM, Hercules A, Fumis L, Miranda A, Carvalho-Silva D, Buniello A, Burdett T, Hayhurst J, Baker J, Ferrer J, Gonzalez-Uriarte A, Jupp S, Karim MA, Koscielny G, Machlitt-Northen S, Malangone C, Pendlington ZM, Roncaglia P, Suveges D, Wright D, Vrousgou O, Papa E, Parkinson H, MacArthur JAL, Todd JA, Barrett JC, Schwartzentruber J, Hulcoop DG, Ochoa D, McDonagh EM, Dunham I. Ghoussaini M, et al. Among authors: machlitt northen s. Nucleic Acids Res. 2021 Jan 8;49(D1):D1311-D1320. doi: 10.1093/nar/gkaa840. Nucleic Acids Res. 2021. PMID: 33045747 Free PMC article.