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Does Serum Urate Change as Parkinson's Disease Progresses?
Hasimoglu YG, Chen X, Bakshi R, Schwarzschild MA, Macklin EA. Hasimoglu YG, et al. Among authors: macklin ea. J Parkinsons Dis. 2020;10(4):1571-1576. doi: 10.3233/JPD-202064. J Parkinsons Dis. 2020. PMID: 32773396 Free PMC article.
Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial.
Parkinson Study Group SURE-PD Investigators; Schwarzschild MA, Ascherio A, Beal MF, Cudkowicz ME, Curhan GC, Hare JM, Hooper DC, Kieburtz KD, Macklin EA, Oakes D, Rudolph A, Shoulson I, Tennis MK, Espay AJ, Gartner M, Hung A, Bwala G, Lenehan R, Encarnacion E, Ainslie M, Castillo R, Togasaki D, Barles G, Friedman JH, Niles L, Carter JH, Murray M, Goetz CG, Jaglin J, Ahmed A, Russell DS, Cotto C, Goudreau JL, Russell D, Parashos SA, Ede P, Saint-Hilaire MH, Thomas CA, James R, Stacy MA, Johnson J, Gauger L, Antonelle de Marcaida J, Thurlow S, Isaacson SH, Carvajal L, Rao J, Cook M, Hope-Porche C, McClurg L, Grasso DL, Logan R, Orme C, Ross T, Brocht AF, Constantinescu R, Sharma S, Venuto C, Weber J, Eaton K. Parkinson Study Group SURE-PD Investigators, et al. Among authors: macklin ea. JAMA Neurol. 2014 Feb;71(2):141-50. doi: 10.1001/jamaneurol.2013.5528. JAMA Neurol. 2014. PMID: 24366103 Free PMC article. Clinical Trial.
Urate and neuroprotection trials.
Schwarzschild MA, Macklin EA, Ascherio A; Parkinson Study Group SURE-PD Investigators. Schwarzschild MA, et al. Among authors: macklin ea. Lancet Neurol. 2014 Aug;13(8):758. doi: 10.1016/S1474-4422(14)70138-3. Lancet Neurol. 2014. PMID: 25030508 No abstract available.
Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials.
Espay AJ, Schwarzschild MA, Tanner CM, Fernandez HH, Simon DK, Leverenz JB, Merola A, Chen-Plotkin A, Brundin P, Kauffman MA, Erro R, Kieburtz K, Woo D, Macklin EA, Standaert DG, Lang AE. Espay AJ, et al. Among authors: macklin ea. Mov Disord. 2017 Mar;32(3):319-324. doi: 10.1002/mds.26913. Epub 2017 Feb 24. Mov Disord. 2017. PMID: 28233927 Free PMC article. Review.
Cardiovascular Safety of Febuxostat.
Bhattacharyya S, Macklin EA, Schwarzschild MA. Bhattacharyya S, et al. Among authors: macklin ea. N Engl J Med. 2018 Oct 18;379(16):1582. doi: 10.1056/NEJMc1809736. N Engl J Med. 2018. PMID: 30338966 No abstract available.
Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.
Chen X, Umeh CC, Tainsh RE, Feng DD, Maguire M, Zuo F, Rahimian M, Logan R, Wang X, Ascherio A, Macklin EA, Buys ES, Schwarzschild MA; Parkinson Study Group (PSG) The Safety of Urate Elevation in Parkinson's Disease (SURE-PD) investigators. Chen X, et al. Among authors: macklin ea. EBioMedicine. 2018 Nov;37:259-268. doi: 10.1016/j.ebiom.2018.10.039. Epub 2018 Nov 8. EBioMedicine. 2018. PMID: 30415890 Free PMC article. Clinical Trial.
Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis.
Nicholson K, Chan J, Macklin EA, Levine-Weinberg M, Breen C, Bakshi R, Grasso DL, Wills AM, Jahandideh S, Taylor AA, Beaulieu D, Ennist DL, Andronesi O, Ratai EM, Schwarzschild MA, Cudkowicz M, Paganoni S. Nicholson K, et al. Among authors: macklin ea. Ann Clin Transl Neurol. 2018 Oct 22;5(12):1522-1533. doi: 10.1002/acn3.671. eCollection 2018 Dec. Ann Clin Transl Neurol. 2018. PMID: 30564619 Free PMC article.
Higher urate in LRRK2 mutation carriers resistant to Parkinson disease.
Bakshi R, Macklin EA, Logan R, Zorlu MM, Xia N, Crotty GF, Zhang E, Chen X, Ascherio A, Schwarzschild MA. Bakshi R, et al. Among authors: macklin ea. Ann Neurol. 2019 Apr;85(4):593-599. doi: 10.1002/ana.25436. Epub 2019 Mar 3. Ann Neurol. 2019. PMID: 30761591
197 results