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Year Number of Results
2007 1
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2011 5
2012 5
2013 10
2014 5
2015 6
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2017 6
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2021 16
2022 14
2023 7
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121 results

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MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3beta/beta-catenin signaling.
Zhou ZJ, Luo CB, Xin HY, Hu ZQ, Zhu GQ, Li J, Zhou SL. Zhou ZJ, et al. NPJ Genom Med. 2020 Apr 1;5:15. doi: 10.1038/s41525-020-0122-7. eCollection 2020. NPJ Genom Med. 2020. PMID: 32257385 Free PMC article.
In this study, through whole-genome sequencing (WGS), we identified MACROD2 as the gene most frequently affected by SVs, which were associated with low MACROD2 expression levels. ...Mechanistically, MACROD2 deficiency suppressed glycogen synthase kinase-3beta …
In this study, through whole-genome sequencing (WGS), we identified MACROD2 as the gene most frequently affected by SVs, which were a …
Multiple crystal forms of human MacroD2.
Wazir S, Maksimainen MM, Lehtiö L. Wazir S, et al. Acta Crystallogr F Struct Biol Commun. 2020 Oct 1;76(Pt 10):477-482. doi: 10.1107/S2053230X20011309. Epub 2020 Sep 15. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 33006575 Free PMC article.
MacroD2 is a single-domain protein that contains a deep ADP-ribose-binding groove. ...These conformational variations may potentially facilitate design efforts of a MacroD2 inhibitor....
MacroD2 is a single-domain protein that contains a deep ADP-ribose-binding groove. ...These conformational variations may potentially …
MACROD2, an Original Cause of CIN?
Jin N, Burkard ME. Jin N, et al. Cancer Discov. 2018 Aug;8(8):921-923. doi: 10.1158/2159-8290.CD-18-0674. Cancer Discov. 2018. PMID: 30076143
The fundamental cause of chromosomal instability in colorectal cancer remains elusive. Genetic deletions of the MACROD2 tumor suppressor could play a major role. Cancer Discov; 8(8); 921-3. 2018 AACRSee related article by Sakthianandeswaren et al., p. 988....
The fundamental cause of chromosomal instability in colorectal cancer remains elusive. Genetic deletions of the MACROD2 tumor suppres …
Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
Crawford K, Oliver PL, Agnew T, Hunn BHM, Ahel I. Crawford K, et al. Cells. 2021 Feb 10;10(2):368. doi: 10.3390/cells10020368. Cells. 2021. PMID: 33578760 Free PMC article.
Therefore, here we analysed both Macrod1 and Macrod2 gene knockout (KO) mouse models in a battery of well-defined, spontaneous behavioural testing paradigms. Loss of Macrod1 resulted in a female-specific motor-coordination defect, whereas Macrod2 disruption was asso …
Therefore, here we analysed both Macrod1 and Macrod2 gene knockout (KO) mouse models in a battery of well-defined, spontaneous behavi …
MACROD2 expression predicts response to 5-FU-based chemotherapy in stage III colon cancer.
van den Broek E, den Uil SH, Coupé VMH, Delis-van Diemen PM, Bolijn AS, Bril H, Stockmann HBAC, van Grieken NCT, Meijer GA, Fijneman RJA. van den Broek E, et al. Oncotarget. 2018 Jun 29;9(50):29445-29452. doi: 10.18632/oncotarget.25655. eCollection 2018 Jun 29. Oncotarget. 2018. PMID: 30034629 Free PMC article.
BACKGROUND: Colorectal cancer (CRC) is caused by genetic aberrations. MACROD2 is commonly involved in somatic focal DNA copy number losses, in more than one-third of CRCs. In this study, we aimed to investigate the association of MACROD2 protein expression with clin …
BACKGROUND: Colorectal cancer (CRC) is caused by genetic aberrations. MACROD2 is commonly involved in somatic focal DNA copy number l …
The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis.
Feijs KLH, Cooper CDO, Žaja R. Feijs KLH, et al. Cancers (Basel). 2020 Mar 5;12(3):604. doi: 10.3390/cancers12030604. Cancers (Basel). 2020. PMID: 32151005 Free PMC article. Review.
MACROD1, MACROD2, and TARG1 have a 'macrodomain' harbouring the catalytic site, but no other domains have been identified. ...In this review, we critically assess the available literature on a role for the hydrolases in cancer and find that, currently, there is limited evi …
MACROD1, MACROD2, and TARG1 have a 'macrodomain' harbouring the catalytic site, but no other domains have been identified. ...In this …
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.
Mohseni M, Cidado J, Croessmann S, Cravero K, Cimino-Mathews A, Wong HY, Scharpf R, Zabransky DJ, Abukhdeir AM, Garay JP, Wang GM, Beaver JA, Cochran RL, Blair BG, Rosen DM, Erlanger B, Argani P, Hurley PJ, Lauring J, Park BH. Mohseni M, et al. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17606-11. doi: 10.1073/pnas.1408650111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422431 Free PMC article.
We found MACROD2 is amplified and overexpressed in metastatic tamoxifen-resistant tumors. ...MACROD2 overexpression also leads to estrogen independent growth in xenograft assays. ...
We found MACROD2 is amplified and overexpressed in metastatic tamoxifen-resistant tumors. ...MACROD2 overexpression also leads …
MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
Sakthianandeswaren A, Parsons MJ, Mouradov D, MacKinnon RN, Catimel B, Liu S, Palmieri M, Love C, Jorissen RN, Li S, Whitehead L, Putoczki TL, Preaudet A, Tsui C, Nowell CJ, Ward RL, Hawkins NJ, Desai J, Gibbs P, Ernst M, Street I, Buchert M, Sieber OM. Sakthianandeswaren A, et al. Cancer Discov. 2018 Aug;8(8):988-1005. doi: 10.1158/2159-8290.CD-17-0909. Epub 2018 Jun 7. Cancer Discov. 2018. PMID: 29880585
We identify MACROD2 deletion as a cause of CIN in human colorectal cancer. MACROD2 loss causes repression of PARP1 activity, impairing DNA repair. MACROD2 haploinsufficiency promotes CIN and intestinal tumor growth. ...
We identify MACROD2 deletion as a cause of CIN in human colorectal cancer. MACROD2 loss causes repression of PARP1 activity, i …
Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults.
Lo Re O, Mazza T, Vinciguerra M. Lo Re O, et al. Front Genet. 2018 Dec 12;9:654. doi: 10.3389/fgene.2018.00654. eCollection 2018. Front Genet. 2018. PMID: 30619475 Free PMC article.
MACROD2 knock-out mice were viable and healthy, indistinguishable from wild type littermates. High-fat diet administration induced obesity, and glucose/insulin intolerance in mice independent of MACROD2 gene deletion. Moreover, sub-lethal irradiation did not indicat …
MACROD2 knock-out mice were viable and healthy, indistinguishable from wild type littermates. High-fat diet administration induced ob …
121 results