Magnani JL - Search Results

1

Probing the carbohydrate recognition domain of E-selectin: the importance of the acid orientation in sLex mimetics.

Titz A, Patton J, Smiesko M, Radic Z, Schwardt O, Magnani JL, Ernst B. Titz A, et al. Among authors: magnani jl. Bioorg Med Chem. 2010 Jan 1;18(1):19-27. doi: 10.1016/j.bmc.2009.11.024. Epub 2009 Nov 13. Bioorg Med Chem. 2010. PMID: 19948406

2

Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists?

Titz A, Patton J, Alker AM, Porro M, Schwardt O, Hennig M, Francotte E, Magnani J, Ernst B. Titz A, et al. Bioorg Med Chem. 2008 Jan 15;16(2):1046-56. doi: 10.1016/j.bmc.2007.07.025. Epub 2007 Aug 22. Bioorg Med Chem. 2008. PMID: 17845854

3

From carbohydrate leads to glycomimetic drugs.

Ernst B, Magnani JL. Ernst B, et al. Among authors: magnani jl. Nat Rev Drug Discov. 2009 Aug;8(8):661-77. doi: 10.1038/nrd2852. Epub 2009 Jul 24. Nat Rev Drug Discov. 2009. PMID: 19629075 Free PMC article. Review.

4

Synthesis and biological evaluation of a potent E-selectin antagonist.

Thoma G, Kinzy W, Bruns C, Patton JT, Magnani JL, Bänteli R. Thoma G, et al. Among authors: magnani jl. J Med Chem. 1999 Nov 18;42(23):4909-13. doi: 10.1021/jm990422n. J Med Chem. 1999. PMID: 10579852

5

Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition.

Thoma G, Magnani JL, Patton JT. Thoma G, et al. Among authors: magnani jl. Bioorg Med Chem Lett. 2001 Apr 9;11(7):923-5. doi: 10.1016/s0960-894x(01)00092-0. Bioorg Med Chem Lett. 2001. PMID: 11294392

6

Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin.

Hanessian S, Huynh HK, Reddy GV, McNaughton-Smith G, Ernst B, Kolb HC, Magnani J, Sweeley C. Hanessian S, et al. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2803-8. doi: 10.1016/s0960-894x(98)00500-9. Bioorg Med Chem Lett. 1998. PMID: 9873626

7

Pre-organization of the core structure of E-selectin antagonists.

Schwizer D, Patton JT, Cutting B, Smieško M, Wagner B, Kato A, Weckerle C, Binder FP, Rabbani S, Schwardt O, Magnani JL, Ernst B. Schwizer D, et al. Among authors: magnani jl. Chemistry. 2012 Jan 27;18(5):1342-51. doi: 10.1002/chem.201102884. Epub 2011 Dec 30. Chemistry. 2012. PMID: 22213563

8

Implications of the E-selectin S128R mutation for drug discovery.

Preston RC, Rabbani S, Binder FP, Moes S, Magnani JL, Ernst B. Preston RC, et al. Among authors: magnani jl. Glycobiology. 2014 Jul;24(7):592-601. doi: 10.1093/glycob/cwu026. Epub 2014 Mar 31. Glycobiology. 2014. PMID: 24688092 Free PMC article.

9

Nanomolar E-selectin inhibitors: 700-fold potentiation of affinity by multivalent ligand presentation.

Thoma G, Duthaler RO, Magnani JL, Patton JT. Thoma G, et al. Among authors: magnani jl. J Am Chem Soc. 2001 Oct 17;123(41):10113-4. doi: 10.1021/ja0164430. J Am Chem Soc. 2001. PMID: 11592897 No abstract available.

10

Preorganization of the Bioactive Conformation of Sialyl Lewis(X) Analogues Correlates with Their Affinity to E-Selectin.

Thoma G, Magnani JL, Patton JT, Ernst B, Jahnke W. Thoma G, et al. Among authors: magnani jl. Angew Chem Int Ed Engl. 2001 May 18;40(10):1941-1945. Angew Chem Int Ed Engl. 2001. PMID: 11385680 No abstract available.

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