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Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).
Ostergaard P, Simpson MA, Connell FC, Steward CG, Brice G, Woollard WJ, Dafou D, Kilo T, Smithson S, Lunt P, Murday VA, Hodgson S, Keenan R, Pilz DT, Martinez-Corral I, Makinen T, Mortimer PS, Jeffery S, Trembath RC, Mansour S. Ostergaard P, et al. Among authors: makinen t. Nat Genet. 2011 Sep 4;43(10):929-31. doi: 10.1038/ng.923. Nat Genet. 2011. PMID: 21892158
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.
Ostergaard P, Simpson MA, Mendola A, Vasudevan P, Connell FC, van Impel A, Moore AT, Loeys BL, Ghalamkarpour A, Onoufriadis A, Martinez-Corral I, Devery S, Leroy JG, van Laer L, Singer A, Bialer MG, McEntagart M, Quarrell O, Brice G, Trembath RC, Schulte-Merker S, Makinen T, Vikkula M, Mortimer PS, Mansour S, Jeffery S. Ostergaard P, et al. Among authors: makinen t. Am J Hum Genet. 2012 Feb 10;90(2):356-62. doi: 10.1016/j.ajhg.2011.12.018. Epub 2012 Jan 26. Am J Hum Genet. 2012. PMID: 22284827 Free PMC article.
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen VM, Zarkada G, Stanczuk L, Francois M, Mäkinen T, Saharinen P, Immonen I, Alitalo K. Aspelund A, et al. Among authors: makinen t. J Clin Invest. 2014 Sep;124(9):3975-86. doi: 10.1172/JCI75395. Epub 2014 Jul 25. J Clin Invest. 2014. PMID: 25061878 Free PMC article.
VEGFR3 does not sustain retinal angiogenesis without VEGFR2.
Zarkada G, Heinolainen K, Makinen T, Kubota Y, Alitalo K. Zarkada G, et al. Among authors: makinen t. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):761-6. doi: 10.1073/pnas.1423278112. Epub 2015 Jan 5. Proc Natl Acad Sci U S A. 2015. PMID: 25561555 Free PMC article.
Nonvenous origin of dermal lymphatic vasculature.
Martinez-Corral I, Ulvmar MH, Stanczuk L, Tatin F, Kizhatil K, John SW, Alitalo K, Ortega S, Makinen T. Martinez-Corral I, et al. Among authors: makinen t. Circ Res. 2015 May 8;116(10):1649-54. doi: 10.1161/CIRCRESAHA.116.306170. Epub 2015 Mar 3. Circ Res. 2015. PMID: 25737499
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.
Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Laviña B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Mäkinen T. Stanczuk L, et al. Among authors: makinen t. Cell Rep. 2015 Mar 17;10(10):1708-1721. doi: 10.1016/j.celrep.2015.02.026. Epub 2015 Mar 12. Cell Rep. 2015. PMID: 25772358 Free article.
A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research.
Bianchi R, Teijeira A, Proulx ST, Christiansen AJ, Seidel CD, Rülicke T, Mäkinen T, Hägerling R, Halin C, Detmar M. Bianchi R, et al. Among authors: makinen t. PLoS One. 2015 Apr 7;10(4):e0122976. doi: 10.1371/journal.pone.0122976. eCollection 2015. PLoS One. 2015. PMID: 25849579 Free PMC article.
FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature.
Sabine A, Bovay E, Demir CS, Kimura W, Jaquet M, Agalarov Y, Zangger N, Scallan JP, Graber W, Gulpinar E, Kwak BR, Mäkinen T, Martinez-Corral I, Ortega S, Delorenzi M, Kiefer F, Davis MJ, Djonov V, Miura N, Petrova TV. Sabine A, et al. Among authors: makinen t. J Clin Invest. 2015 Oct 1;125(10):3861-77. doi: 10.1172/JCI80454. Epub 2015 Sep 21. J Clin Invest. 2015. PMID: 26389677 Free PMC article.
286 results