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The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.
Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S. Wang H, et al. Among authors: mani s. Mol Endocrinol. 2008 Apr;22(4):838-57. doi: 10.1210/me.2007-0218. Epub 2007 Dec 20. Mol Endocrinol. 2008. PMID: 18096694 Free PMC article.
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh LA, Mani S, Redinbo MR. Wallace BD, et al. Among authors: mani s. Science. 2010 Nov 5;330(6005):831-5. doi: 10.1126/science.1191175. Science. 2010. PMID: 21051639 Free PMC article.
PXR antagonists and implication in drug metabolism.
Mani S, Dou W, Redinbo MR. Mani S, et al. Drug Metab Rev. 2013 Feb;45(1):60-72. doi: 10.3109/03602532.2012.746363. Drug Metab Rev. 2013. PMID: 23330542 Free PMC article. Review.
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.
Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S. Venkatesh M, et al. Among authors: mani s. Immunity. 2014 Aug 21;41(2):296-310. doi: 10.1016/j.immuni.2014.06.014. Epub 2014 Jul 24. Immunity. 2014. PMID: 25065623 Free PMC article.
1,117 results