Mao W - Search Results

1

Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH.

Benkovic SJ, Baker SJ, Alley MR, Woo YH, Zhang YK, Akama T, Mao W, Baboval J, Rajagopalan PT, Wall M, Kahng LS, Tavassoli A, Shapiro L. Benkovic SJ, et al. Among authors: mao w. J Med Chem. 2005 Nov 17;48(23):7468-76. doi: 10.1021/jm050676a. J Med Chem. 2005. PMID: 16279806

2

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.

Baker SJ, Zhang YK, Akama T, Lau A, Zhou H, Hernandez V, Mao W, Alley MR, Sanders V, Plattner JJ. Baker SJ, et al. Among authors: mao w. J Med Chem. 2006 Jul 27;49(15):4447-50. doi: 10.1021/jm0603724. J Med Chem. 2006. PMID: 16854048

3

Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone.

Li X, Zhang YK, Plattner JJ, Mao W, Alley MR, Xia Y, Hernandez V, Zhou Y, Ding CZ, Li J, Shao Z, Zhang H, Xu M. Li X, et al. Among authors: mao w. Bioorg Med Chem Lett. 2013 Feb 15;23(4):963-6. doi: 10.1016/j.bmcl.2012.12.045. Epub 2012 Dec 21. Bioorg Med Chem Lett. 2013. PMID: 23312945

4

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).

Li X, Hernandez V, Rock FL, Choi W, Mak YSL, Mohan M, Mao W, Zhou Y, Easom EE, Plattner JJ, Zou W, Pérez-Herrán E, Giordano I, Mendoza-Losana A, Alemparte C, Rullas J, Angulo-Barturen I, Crouch S, Ortega F, Barros D, Alley MRK. Li X, et al. Among authors: mao w. J Med Chem. 2017 Oct 12;60(19):8011-8026. doi: 10.1021/acs.jmedchem.7b00631. Epub 2017 Sep 27. J Med Chem. 2017. PMID: 28953378

5

Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ. Hernandez V, et al. Among authors: mao w. Antimicrob Agents Chemother. 2013 Mar;57(3):1394-403. doi: 10.1128/AAC.02058-12. Epub 2013 Jan 7. Antimicrob Agents Chemother. 2013. PMID: 23295920 Free PMC article.

6

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.

Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MR. Rock FL, et al. Among authors: mao w. Science. 2007 Jun 22;316(5832):1759-61. doi: 10.1126/science.1142189. Science. 2007. PMID: 17588934

7

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.

Xu H, Sullivan TJ, Sekiguchi J, Kirikae T, Ojima I, Stratton CF, Mao W, Rock FL, Alley MR, Johnson F, Walker SG, Tonge PJ. Xu H, et al. Among authors: mao w. Biochemistry. 2008 Apr 8;47(14):4228-36. doi: 10.1021/bi800023a. Epub 2008 Mar 13. Biochemistry. 2008. PMID: 18335995 Free PMC article.

8

Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.

Seiradake E, Mao W, Hernandez V, Baker SJ, Plattner JJ, Alley MR, Cusack S. Seiradake E, et al. Among authors: mao w. J Mol Biol. 2009 Jul 10;390(2):196-207. doi: 10.1016/j.jmb.2009.04.073. Epub 2009 May 6. J Mol Biol. 2009. PMID: 19426743

9

Characterization of benzoxaborole-based antifungal resistance mutations demonstrates that editing depends on electrostatic stabilization of the leucyl-tRNA synthetase editing cap.

Sarkar J, Mao W, Lincecum TL Jr, Alley MR, Martinis SA. Sarkar J, et al. Among authors: mao w. FEBS Lett. 2011 Oct 3;585(19):2986-91. doi: 10.1016/j.febslet.2011.08.010. Epub 2011 Aug 16. FEBS Lett. 2011. PMID: 21856301 Free PMC article.

10

Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.

Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJ. Robertson GT, et al. Among authors: mao w. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02071-18. doi: 10.1128/AAC.02071-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30745397 Free PMC article.

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