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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 4
2004 4
2005 1
2006 3
2007 20
2008 29
2009 42
2010 36
2011 70
2012 104
2013 144
2014 181
2015 165
2016 183
2017 186
2018 259
2019 272
2020 275
2021 255
2022 100
2023 80
2024 38

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2,062 results

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Page 1
LC3 and Autophagy.
Tanida I, Ueno T, Kominami E. Tanida I, et al. Methods Mol Biol. 2008;445:77-88. doi: 10.1007/978-1-59745-157-4_4. Methods Mol Biol. 2008. PMID: 18425443
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Park HS, Song JW, Park JH, Lim BK, Moon OS, Son HY, Lee JH, Gao B, Won YS, Kwon HJ. Park HS, et al. Autophagy. 2021 Sep;17(9):2549-2564. doi: 10.1080/15548627.2020.1834711. Epub 2020 Nov 16. Autophagy. 2021. PMID: 33190588 Free PMC article.
Upregulation of hepatic TXNIP was positively correlated with impaired autophagy, as evidenced by a decreased number of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 beta) puncta and increased SQSTM1/p62 (sequestosome 1) expression. ...Targeting TXNIP may be …
Upregulation of hepatic TXNIP was positively correlated with impaired autophagy, as evidenced by a decreased number of MAP1LC3B/LC3B …
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
Yan C, Gong L, Chen L, Xu M, Abou-Hamdan H, Tang M, Désaubry L, Song Z. Yan C, et al. Autophagy. 2020 Mar;16(3):419-434. doi: 10.1080/15548627.2019.1628520. Epub 2019 Jun 16. Autophagy. 2020. PMID: 31177901 Free PMC article.
Thus, our findings reveal that the PHB2-PARL-PGAM5-PINK1 axis is a novel pathway of PHB2-mediated mitophagy and that targeting PHB2 with the chemical compound FL3 is a promising strategy for cancer therapy.Abbreviations: AIFM1: apoptosis inducing factor mitochondria associated 1; …
Thus, our findings reveal that the PHB2-PARL-PGAM5-PINK1 axis is a novel pathway of PHB2-mediated mitophagy and that targeting PHB2 with the …
Tumor heterogeneity in autophagy-dependent ferroptosis.
Li J, Liu J, Xu Y, Wu R, Chen X, Song X, Zeh H, Kang R, Klionsky DJ, Wang X, Tang D. Li J, et al. Autophagy. 2021 Nov;17(11):3361-3374. doi: 10.1080/15548627.2021.1872241. Epub 2021 Jan 15. Autophagy. 2021. PMID: 33404288 Free PMC article.
Here, we examine the early dynamic change in protein expression of autophagic (e.g., MAP1LC3B and SQSTM1) or ferroptotic (e.g., SLC7A11 and GPX4) regulators in 60 human cancer cell lines in response to two classical ferroptosis activators (erastin and RSL3) in the absence …
Here, we examine the early dynamic change in protein expression of autophagic (e.g., MAP1LC3B and SQSTM1) or ferroptotic (e.g., SLC7A …
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, Steegborn C, Nowak T, Schutkowski M, Pellegrini L, Sansone L, Villanova L, Runci A, Pucci B, Morgante E, Fini M, Mai A, Russo MA, Tafani M. Polletta L, et al. Autophagy. 2015;11(2):253-70. doi: 10.1080/15548627.2015.1009778. Autophagy. 2015. PMID: 25700560 Free PMC article.
We next determined that autophagy and mitophagy were increased by ammonia by measuring autophagic proteolysis of long-lived proteins, increase of autophagy markers MAP1LC3B, GABARAP, and GABARAPL2, mitophagy markers BNIP3 and the PINK1-PARK2 system as well as mitochondrial …
We next determined that autophagy and mitophagy were increased by ammonia by measuring autophagic proteolysis of long-lived proteins, increa …
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Wang R, Zhu Y, Ren C, Yang S, Tian S, Chen H, Jin M, Zhou H. Wang R, et al. Autophagy. 2021 Feb;17(2):496-511. doi: 10.1080/15548627.2020.1725375. Epub 2020 Feb 11. Autophagy. 2021. PMID: 32013669 Free PMC article.
Further studies revealed that PB1-F2 induced complete mitophagy, which required the interactions of PB1-F2 with both TUFM and MAP1LC3B/LC3B that mediated the autophagosome formation. PB1-F2-induced mitophagy was critical for the MAVS (mitochondrial antiviral signaling prot …
Further studies revealed that PB1-F2 induced complete mitophagy, which required the interactions of PB1-F2 with both TUFM and MAP1LC3B …
Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis.
Yang L, Ye F, Liu J, Klionsky DJ, Tang D, Kang R. Yang L, et al. Autophagy. 2023 Jun;19(6):1733-1744. doi: 10.1080/15548627.2022.2152209. Epub 2022 Dec 5. Autophagy. 2023. PMID: 36426912 Free PMC article.
5-HETE, 5-hydroxyeicosatetraenoic acid; ACSL4, acyl-CoA synthetase long chain family member 4; AP, acute pancreatitis; ATG, autophagy related; AGER, advanced glycosylation end-product specific receptor; DAMPs, danger/damage-associated molecular patterns; FTH1, ferritin heavy chai …
5-HETE, 5-hydroxyeicosatetraenoic acid; ACSL4, acyl-CoA synthetase long chain family member 4; AP, acute pancreatitis; ATG, autophagy relate …
Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy.
Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y, Han Z, Chen L, Gao R, Liu L, Chen Q. Chen M, et al. Autophagy. 2016;12(4):689-702. doi: 10.1080/15548627.2016.1151580. Autophagy. 2016. PMID: 27050458 Free PMC article.
Mitochondrial fragmentation due to imbalanced fission and fusion of mitochondria is a prerequisite for mitophagy, however, the exact "coupling" of mitochondrial dynamics and mitophagy remains unclear. We have previously identified that FUNDC1 recruits MAP1LC3B/LC3B (LC3) t …
Mitochondrial fragmentation due to imbalanced fission and fusion of mitochondria is a prerequisite for mitophagy, however, the exact "coupli …
2,062 results