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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2001 1
2002 2
2003 3
2004 1
2005 6
2006 8
2007 4
2008 9
2009 6
2010 5
2011 4
2012 10
2013 16
2014 22
2015 27
2016 27
2017 17
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2023 29
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291 results

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Page 1
MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer.
Huang H, Han Q, Zheng H, Liu M, Shi S, Zhang T, Yang X, Li Z, Xu Q, Guo H, Lu F, Wang J. Huang H, et al. Cell Death Dis. 2021 Dec 20;13(1):13. doi: 10.1038/s41419-021-04474-1. Cell Death Dis. 2021. PMID: 34930918 Free PMC article.
Firstly, we found that SOX6 could promote autophagy in cervical cancer cells depending on its HMG domain. Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) gene was identified as the direct target gene of SOX6, which was transcriptionally upregulated by bind …
Firstly, we found that SOX6 could promote autophagy in cervical cancer cells depending on its HMG domain. Mitogen-activated protein kinase k …
MAP4K4 and cancer: ready for the main stage?
González-Montero J, Rojas CI, Burotto M. González-Montero J, et al. Front Oncol. 2023 May 8;13:1162835. doi: 10.3389/fonc.2023.1162835. eCollection 2023. Front Oncol. 2023. PMID: 37223681 Free PMC article. Review.
MAP4K4 is a serine/threonine kinase that belongs to the MAP kinase family and plays a critical role in embryogenesis and cellular migration. ...Over the last few years, specific MAP4K4 inhibitors such as GNE-495 have been developed but have not yet been tested in ca …
MAP4K4 is a serine/threonine kinase that belongs to the MAP kinase family and plays a critical role in embryogenesis and cellular mig …
MAP4K4: an emerging therapeutic target in cancer.
Gao X, Gao C, Liu G, Hu J. Gao X, et al. Cell Biosci. 2016 Oct 28;6:56. doi: 10.1186/s13578-016-0121-7. eCollection 2016. Cell Biosci. 2016. PMID: 27800153 Free PMC article. Review.
Information regarding MAP4K4 in cancers is extremely limited, but increasing evidence suggests that MAP4K4 also plays an important role in cancer and MAP4K4 may represent a novel actionable cancer therapeutic target. This review summarizes our current underst …
Information regarding MAP4K4 in cancers is extremely limited, but increasing evidence suggests that MAP4K4 also plays an impor …
MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage.
Chen K, Yuan X, Wang S, Zheng F, Fu Z, Shen Z, Cheng X, Wang Y, Tang S, Ni H, Wang F, Lu G, Wu Y, Xia D, Lu W. Chen K, et al. Oncogene. 2023 May;42(18):1438-1452. doi: 10.1038/s41388-023-02650-5. Epub 2023 Mar 15. Oncogene. 2023. PMID: 36922678 Free PMC article.
Down regulation of MAP4K4 inhibited cancer cell adhesion, migration, and invasion. Notably, MAP4K4 was found to stabilize N-cadherin. ...Pharmacologic inhibition of MAP4K4 abrogated peritoneal metastases. Overall, our data reveal MAP4K4 as a significan …
Down regulation of MAP4K4 inhibited cancer cell adhesion, migration, and invasion. Notably, MAP4K4 was found to stabilize N-ca …
Molecular Insights of MAP4K4 Signaling in Inflammatory and Malignant Diseases.
Singh SK, Roy R, Kumar S, Srivastava P, Jha S, Rana B, Rana A. Singh SK, et al. Cancers (Basel). 2023 Apr 13;15(8):2272. doi: 10.3390/cancers15082272. Cancers (Basel). 2023. PMID: 37190200 Free PMC article. Review.
Overexpression of MAP4K4 is frequently reported in many cancers, including glioblastoma, colon, prostate, and pancreatic cancers. Besides its mainstay pro-survival role in various malignancies, MAP4K4 has been implicated in cancer-associated cachexia. In the present …
Overexpression of MAP4K4 is frequently reported in many cancers, including glioblastoma, colon, prostate, and pancreatic cancers. Bes …
Neutralizing MAP4K4.
Nicholls M. Nicholls M. Eur Heart J. 2019 Jun 7;40(22):1752-1753. doi: 10.1093/eurheartj/ehz365. Eur Heart J. 2019. PMID: 31173092 No abstract available.
Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases.
Virbasius JV, Czech MP. Virbasius JV, et al. Trends Endocrinol Metab. 2016 Jul;27(7):484-492. doi: 10.1016/j.tem.2016.04.006. Epub 2016 May 6. Trends Endocrinol Metab. 2016. PMID: 27160798 Free PMC article. Review.
Recent studies have shown that Map4k4 gene ablation or inhibition of its kinase activity attenuates hyperglycemia and plaque formation in mouse models of insulin resistance and atherosclerosis, and suggest roles for Map4k4 in multiple signaling systems, including NF …
Recent studies have shown that Map4k4 gene ablation or inhibition of its kinase activity attenuates hyperglycemia and plaque formatio …
Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.
Patterson V, Ullah F, Bryant L, Griffin JN, Sidhu A, Saliganan S, Blaile M, Saenz MS, Smith R, Ellingwood S, Grange DK, Hu X, Mireguli M, Luo Y, Shen Y, Mulhern M, Zackai E, Ritter A, Izumi K, Hoefele J, Wagner M, Riedhammer KM, Seitz B, Robin NH, Goodloe D, Mignot C, Keren B, Cox H, Jarvis J, Hempel M, Gibson CF, Tran Mau-Them F, Vitobello A, Bruel AL, Sorlin A, Mehta S, Raymond FL, Gilmore K, Powell BC, Weck K, Li C, Vulto-van Silfhout AT, Giacomini T, Mancardi MM, Accogli A, Salpietro V, Zara F, Vora NL, Davis EE, Burdine R, Bhoj E. Patterson V, et al. Sci Adv. 2023 Apr 28;9(17):eade0631. doi: 10.1126/sciadv.ade0631. Epub 2023 Apr 26. Sci Adv. 2023. PMID: 37126546 Free PMC article.
Using several zebrafish models, we demonstrate that these human variants are either loss-of-function or dominant-negative alleles and show that decreasing Map4k4 activity causes developmental defects. Furthermore, MAP4K4 can restrain hyperactive RAS signaling in ear …
Using several zebrafish models, we demonstrate that these human variants are either loss-of-function or dominant-negative alleles and show t …
MAP4K4 is involved in the neuronal development of retinal photoreceptors.
Huang H, Kuang X, Zou Y, Zeng J, Du H, Tang H, Long C, Mao Y, Yu X, Wen C, Yan J, Shen H. Huang H, et al. Exp Eye Res. 2023 Aug;233:109524. doi: 10.1016/j.exer.2023.109524. Epub 2023 Jun 7. Exp Eye Res. 2023. PMID: 37290629
Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) is a potential regulator of photoreceptor development. To investigate the mechanisms underlying MAP4K4 during the neuronal development of retinal photoreceptors, we generated knockout models of C57BL/6 …
Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) is a potential regulator of photoreceptor development. To investigat …
MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes.
Chuang HC, Tan TH. Chuang HC, et al. J Biomed Sci. 2017 Jan 7;24(1):4. doi: 10.1186/s12929-016-0307-7. J Biomed Sci. 2017. PMID: 28061846 Free PMC article. Review.
Moreover, MAP4K4 single nucleotide polymorphisms and epigenetic changes are associated with T2D patients. Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D. ...
Moreover, MAP4K4 single nucleotide polymorphisms and epigenetic changes are associated with T2D patients. Interactions between MAP …
291 results