Martásek P - Search Results

1

Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases.

Huang H, Martásek P, Roman LJ, Silverman RB. Huang H, et al. Among authors: martasek p. J Med Chem. 2000 Jul 27;43(15):2938-45. doi: 10.1021/jm000127z. J Med Chem. 2000. PMID: 10956202

Recently, we reported dipeptide amides containing a basic amine side chain as potent and selective inhibitors of neuronal NOS (Huang, H.; Martasek, P.; Roman, L. J.; Masters, B. S. S.; Silverman, R. B. J. ...

Recently, we reported dipeptide amides containing a basic amine side chain as potent and selective inhibitors of neuronal NOS (Huang, H.; …

2

Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.

Ji H, Tan S, Igarashi J, Li H, Derrick M, Martásek P, Roman LJ, Vásquez-Vivar J, Poulos TL, Silverman RB. Ji H, et al. Among authors: martasek p. Ann Neurol. 2009 Feb;65(2):209-17. doi: 10.1002/ana.21555. Ann Neurol. 2009. PMID: 19235180 Free PMC article.

3

Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.

Lawton GR, Ralay Ranaivo H, Chico LK, Ji H, Xue F, Martásek P, Roman LJ, Watterson DM, Silverman RB. Lawton GR, et al. Among authors: martasek p. Bioorg Med Chem. 2009 Mar 15;17(6):2371-80. doi: 10.1016/j.bmc.2009.02.017. Epub 2009 Feb 14. Bioorg Med Chem. 2009. PMID: 19268602 Free PMC article.

4

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase.

Lawton GR, Ji H, Martásek P, Roman LJ, Silverman RB. Lawton GR, et al. Among authors: martasek p. Beilstein J Org Chem. 2009 Jun 4;5:28. doi: 10.3762/bjoc.5.28. Beilstein J Org Chem. 2009. PMID: 19590740 Free PMC article.

5

Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.

Xue F, Fang J, Lewis WW, Martásek P, Roman LJ, Silverman RB. Xue F, et al. Among authors: martasek p. Bioorg Med Chem Lett. 2010 Jan 15;20(2):554-7. doi: 10.1016/j.bmcl.2009.11.086. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 19963381 Free PMC article.

Recently, a series of potent and selective neuronal nitric oxide synthase inhibitors containing two basic nitrogen atoms was reported (Ji, H.; Stanton, B. Z.; Igarashi, J.; Li, H.; Martasek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. J. Am. ...

Recently, a series of potent and selective neuronal nitric oxide synthase inhibitors containing two basic nitrogen atoms was reported (Ji, H …

6

Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.

Martell JD, Li H, Doukov T, Martásek P, Roman LJ, Soltis M, Poulos TL, Silverman RB. Martell JD, et al. Among authors: martasek p. J Am Chem Soc. 2010 Jan 20;132(2):798-806. doi: 10.1021/ja908544f. J Am Chem Soc. 2010. PMID: 20014790 Free PMC article.

7

Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.

Xue F, Huang J, Ji H, Fang J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Xue F, et al. Among authors: martasek p. Bioorg Med Chem. 2010 Sep 1;18(17):6526-37. doi: 10.1016/j.bmc.2010.06.074. Epub 2010 Jul 1. Bioorg Med Chem. 2010. PMID: 20673724 Free PMC article.

8

Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.

Xue F, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. Xue F, et al. Among authors: martasek p. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6258-61. doi: 10.1016/j.bmcl.2010.08.096. Epub 2010 Aug 26. Bioorg Med Chem Lett. 2010. PMID: 20833542 Free PMC article.

9

Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase.

Xue F, Li H, Delker SL, Fang J, Martásek P, Roman LJ, Poulos TL, Silverman RB. Xue F, et al. Among authors: martasek p. J Am Chem Soc. 2010 Oct 13;132(40):14229-38. doi: 10.1021/ja106175q. J Am Chem Soc. 2010. PMID: 20843082 Free PMC article.

10

Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.

Ji H, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Ji H, et al. Among authors: martasek p. J Med Chem. 2010 Nov 11;53(21):7804-24. doi: 10.1021/jm100947x. J Med Chem. 2010. PMID: 20958055 Free PMC article.

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