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Affimer proteins are versatile and renewable affinity reagents.
Tiede C, Bedford R, Heseltine SJ, Smith G, Wijetunga I, Ross R, AlQallaf D, Roberts AP, Balls A, Curd A, Hughes RE, Martin H, Needham SR, Zanetti-Domingues LC, Sadigh Y, Peacock TP, Tang AA, Gibson N, Kyle H, Platt GW, Ingram N, Taylor T, Coletta LP, Manfield I, Knowles M, Bell S, Esteves F, Maqbool A, Prasad RK, Drinkhill M, Bon RS, Patel V, Goodchild SA, Martin-Fernandez M, Owens RJ, Nettleship JE, Webb ME, Harrison M, Lippiat JD, Ponnambalam S, Peckham M, Smith A, Ferrigno PK, Johnson M, McPherson MJ, Tomlinson DC. Tiede C, et al. Among authors: martin fernandez m, martin h. Elife. 2017 Jun 27;6:e24903. doi: 10.7554/eLife.24903. Elife. 2017. PMID: 28654419 Free PMC article.
Multidrug-resistant breast cancer: current perspectives.
Martin HL, Smith L, Tomlinson DC. Martin HL, et al. Breast Cancer (Dove Med Press). 2014 Jan 10;6:1-13. doi: 10.2147/BCTT.S37638. eCollection 2014. Breast Cancer (Dove Med Press). 2014. PMID: 24648765 Free PMC article. Review.
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site.
Haza KZ, Martin HL, Rao A, Turner AL, Saunders SE, Petersen B, Tiede C, Tipping K, Tang AA, Ajayi M, Taylor T, Harvey M, Fishwick KM, Adams TL, Gaule TG, Trinh CH, Johnson M, Breeze AL, Edwards TA, McPherson MJ, Tomlinson DC. Haza KZ, et al. Among authors: martin hl. Nat Commun. 2021 Jun 30;12(1):4045. doi: 10.1038/s41467-021-24316-0. Nat Commun. 2021. PMID: 34193876 Free PMC article.
Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition.
Martin HL, Turner AL, Higgins J, Tang AA, Tiede C, Taylor T, Siripanthong S, Adams TL, Manfield IW, Bell SM, Morrison EE, Bond J, Trinh CH, Hurst CD, Knowles MA, Bayliss RW, Tomlinson DC. Martin HL, et al. Cell Rep. 2023 Oct 31;42(10):113184. doi: 10.1016/j.celrep.2023.113184. Epub 2023 Sep 29. Cell Rep. 2023. PMID: 37776520 Free article.
Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.
Webster PJ, Littlejohns AT, Gaunt HJ, Young RS, Rode B, Ritchie JE, Stead LF, Harrison S, Droop A, Martin HL, Tomlinson DC, Hyman AJ, Appleby HL, Boxall S, Bruns AF, Li J, Prasad RK, Lodge JPA, Burke DA, Beech DJ. Webster PJ, et al. Oncotarget. 2017 Jun 27;8(26):42288-42299. doi: 10.18632/oncotarget.15039. Oncotarget. 2017. PMID: 28178688 Free PMC article.
2,793 results