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Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice.
Jury N, Abarzua S, Diaz I, Guerra MV, Ampuero E, Cubillos P, Martinez P, Herrera-Soto A, Arredondo C, Rojas F, Manterola M, Rojas A, Montecino M, Varela-Nallar L, van Zundert B. Jury N, et al. Among authors: martinez p. Clin Epigenetics. 2020 Feb 18;12(1):32. doi: 10.1186/s13148-020-0816-9. Clin Epigenetics. 2020. PMID: 32070418 Free PMC article.
The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.
Moutinho M, Puntambekar SS, Tsai AP, Coronel I, Lin PB, Casali BT, Martinez P, Oblak AL, Lasagna-Reeves CA, Lamb BT, Landreth GE. Moutinho M, et al. Among authors: martinez p. Sci Transl Med. 2022 Mar 23;14(637):eabl7634. doi: 10.1126/scitranslmed.abl7634. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320002 Free PMC article.
Activated endothelial cells induce a distinct type of astrocytic reactivity.
Taylor X, Cisternas P, Jury N, Martinez P, Huang X, You Y, Redding-Ochoa J, Vidal R, Zhang J, Troncoso J, Lasagna-Reeves CA. Taylor X, et al. Among authors: martinez p. Commun Biol. 2022 Mar 29;5(1):282. doi: 10.1038/s42003-022-03237-8. Commun Biol. 2022. PMID: 35351973 Free PMC article.
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE. Moutinho M, et al. Among authors: martinez p. Genome Med. 2023 Feb 20;15(1):11. doi: 10.1186/s13073-023-01160-z. Genome Med. 2023. PMID: 36805764 Free PMC article.
Network analysis identifies strain-dependent response to tau and tau seeding-associated genes.
Acri DJ, You Y, Tate MD, Karahan H, Martinez P, McCord B, Sharify AD, John S, Kim B, Dabin LC, Philtjens S, Wijeratne HRS, McCray TJ, Smith DC, Bissel SJ, Lamb BT, Lasagna-Reeves CA, Kim J. Acri DJ, et al. Among authors: martinez p. J Exp Med. 2023 Nov 6;220(11):e20230180. doi: 10.1084/jem.20230180. Epub 2023 Aug 22. J Exp Med. 2023. PMID: 37606887 Free PMC article.
NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac.
Bustos FJ, Jury N, Martinez P, Ampuero E, Campos M, Abarzúa S, Jaramillo K, Ibing S, Mardones MD, Haensgen H, Kzhyshkowska J, Tevy MF, Neve R, Sanhueza M, Varela-Nallar L, Montecino M, van Zundert B. Bustos FJ, et al. Among authors: martinez p. J Cell Physiol. 2017 Dec;232(12):3677-3692. doi: 10.1002/jcp.25843. Epub 2017 May 11. J Cell Physiol. 2017. PMID: 28160495
Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR-dependent transmission and short-term fear memory in the basolateral amygdala.
Linsambarth S, Carvajal FJ, Moraga-Amaro R, Mendez L, Tamburini G, Jimenez I, Verdugo DA, Gómez GI, Jury N, Martínez P, van Zundert B, Varela-Nallar L, Retamal MA, Martin C, Altenberg GA, Fiori MC, Cerpa W, Orellana JA, Stehberg J. Linsambarth S, et al. Among authors: martinez p. FASEB J. 2022 Feb;36(2):e22134. doi: 10.1096/fj.202100798RR. FASEB J. 2022. PMID: 35061296
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.
Arredondo C, Cefaliello C, Dyrda A, Jury N, Martinez P, Díaz I, Amaro A, Tran H, Morales D, Pertusa M, Stoica L, Fritz E, Corvalán D, Abarzúa S, Méndez-Ruette M, Fernández P, Rojas F, Kumar MS, Aguilar R, Almeida S, Weiss A, Bustos FJ, González-Nilo F, Otero C, Tevy MF, Bosco DA, Sáez JC, Kähne T, Gao FB, Berry JD, Nicholson K, Sena-Esteves M, Madrid R, Varela D, Montecino M, Brown RH, van Zundert B. Arredondo C, et al. Among authors: martinez p. Neuron. 2022 May 18;110(10):1656-1670.e12. doi: 10.1016/j.neuron.2022.02.010. Epub 2022 Mar 10. Neuron. 2022. PMID: 35276083 Free PMC article.
1,982 results