Maruyama T - Search Results

1

Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.

Kambe T, Maruyama T, Nakai Y, Yoshida H, Oida H, Maruyama T, Abe N, Nishiura A, Nakai H, Toda M. Kambe T, et al. Among authors: maruyama t. Bioorg Med Chem. 2012 Apr 1;20(7):2235-51. doi: 10.1016/j.bmc.2012.02.018. Epub 2012 Feb 16. Bioorg Med Chem. 2012. PMID: 22386979

2

Design and synthesis of a selective EP4-receptor agonist. Part 1: discovery of 3,7-dithiaPGE1 derivatives and identification of their omega chains.

Maruyama T, Asada M, Shiraishi T, Egashira H, Yoshida H, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M. Maruyama T, et al. Bioorg Med Chem. 2002 Apr;10(4):975-88. doi: 10.1016/s0968-0896(01)00351-0. Bioorg Med Chem. 2002. PMID: 11836107

3

Design and synthesis of a selective EP4-receptor agonist. Part 2: 3,7-dithiaPGE1 derivatives with high selectivity.

Maruyama T, Asada M, Shiraishi T, Ishida A, Yoshida H, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M. Maruyama T, et al. Bioorg Med Chem. 2002 Apr;10(4):989-1008. doi: 10.1016/s0968-0896(01)00352-2. Bioorg Med Chem. 2002. PMID: 11836108

4

Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability.

Maruyama T, Asada M, Shiraishi T, Yoshida H, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M. Maruyama T, et al. Bioorg Med Chem. 2002 Jun;10(6):1743-59. doi: 10.1016/s0968-0896(02)00031-7. Bioorg Med Chem. 2002. PMID: 11937333

5

Design and synthesis of a selective EP4-receptor agonist. Part 4: practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist.

Maruyama T, Kuwabe SI, Kawanaka Y, Shiraishi T, Shinagawa Y, Sakata K, Seki A, Kishida Y, Yoshida H, Maruyama T, Ohuchida S, Nakai H, Hashimoto S, Kawamura M, Kondo K, Toda M. Maruyama T, et al. Bioorg Med Chem. 2002 Jul;10(7):2103-10. doi: 10.1016/s0968-0896(02)00085-8. Bioorg Med Chem. 2002. PMID: 11983506

6

Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity.

Kambe T, Maruyama T, Nakano M, Nakai Y, Yoshida T, Matsunaga N, Oida H, Konaka A, Maruyama T, Nakai H, Toda M. Kambe T, et al. Among authors: maruyama t. Bioorg Med Chem Lett. 2012 Jan 1;22(1):396-401. doi: 10.1016/j.bmcl.2011.10.109. Epub 2011 Nov 7. Bioorg Med Chem Lett. 2012. PMID: 22119471

7

Discovery of an 8-aza-5-thiaProstaglandin E1 analog as a highly selective EP4 receptor agonist.

Kambe T, Maruyama T, Naganawa A, Asada M, Seki A, Maruyama T, Nakai H, Toda M. Kambe T, et al. Among authors: maruyama t. Chem Pharm Bull (Tokyo). 2011;59(12):1494-508. doi: 10.1248/cpb.59.1494. Chem Pharm Bull (Tokyo). 2011. PMID: 22130372 Free article.

8

Discovery of orally available 8-aza-5-thiaProstaglandin E1 analogs as highly selective EP4 agonists.

Kambe T, Maruyama T, Nakano M, Yamaura Y, Shono T, Seki A, Sakata K, Maruyama T, Nakai H, Toda M. Kambe T, et al. Among authors: maruyama t. Chem Pharm Bull (Tokyo). 2011;59(12):1523-34. doi: 10.1248/cpb.59.1523. Chem Pharm Bull (Tokyo). 2011. PMID: 22130375 Free article.

9

Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists.

Kambe T, Maruyama T, Nagase T, Ogawa S, Minamoto C, Sakata K, Maruyama T, Nakai H, Toda M. Kambe T, et al. Among authors: maruyama t. Bioorg Med Chem. 2012 Jan 15;20(2):702-13. doi: 10.1016/j.bmc.2011.12.009. Epub 2011 Dec 13. Bioorg Med Chem. 2012. PMID: 22204740

10

Synthesis and evaluation of γ-lactam analogs of PGE₂ as EP4 and EP2/EP4 agonists.

Kambe T, Maruyama T, Nakai Y, Oida H, Maruyama T, Abe N, Nishiura A, Nakai H, Toda M. Kambe T, et al. Among authors: maruyama t. Bioorg Med Chem. 2012 Jun 1;20(11):3502-22. doi: 10.1016/j.bmc.2012.04.008. Epub 2012 Apr 11. Bioorg Med Chem. 2012. PMID: 22546206

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