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CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin.
Exp Dermatol. 2015 Feb;24(2):133-9. doi: 10.1111/exd.12603. Epub 2015 Jan 12.
Exp Dermatol. 2015.
PMID: 25425469
Free PMC article.
Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin.
Mathes AL, Christmann RB, Stifano G, Affandi AJ, Radstake TR, Farina GA, Padilla C, McLaughlin S, Lafyatis R.
Mathes AL, et al.
Ann Rheum Dis. 2014 Oct;73(10):1864-72. doi: 10.1136/annrheumdis-2012-202814. Epub 2013 Jul 19.
Ann Rheum Dis. 2014.
PMID: 23873879
Free PMC article.
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Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor β.
Christmann RB, Mathes A, Affandi AJ, Padilla C, Nazari B, Bujor AM, Stifano G, Lafyatis R.
Christmann RB, et al.
Arthritis Rheum. 2013 May;65(5):1335-46. doi: 10.1002/art.37859.
Arthritis Rheum. 2013.
PMID: 23335246
Free PMC article.
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Role for Toll-like receptor 3 in muscle regeneration after cardiotoxin injury.
Mathes AL, Lafyatis R.
Mathes AL, et al.
Muscle Nerve. 2011 May;43(5):733-40. doi: 10.1002/mus.21959. Epub 2011 Apr 1.
Muscle Nerve. 2011.
PMID: 21462209
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Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis.
Stifano G, Affandi AJ, Mathes AL, Rice LM, Nakerakanti S, Nazari B, Lee J, Christmann RB, Lafyatis R.
Stifano G, et al. Among authors: mathes al.
Arthritis Res Ther. 2014 Jul 1;16(4):R136. doi: 10.1186/ar4598.
Arthritis Res Ther. 2014.
PMID: 24984848
Free PMC article.
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A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis.
Rice LM, Ziemek J, Stratton EA, McLaughlin SR, Padilla CM, Mathes AL, Christmann RB, Stifano G, Browning JL, Whitfield ML, Spiera RF, Gordon JK, Simms RW, Zhang Y, Lafyatis R.
Rice LM, et al. Among authors: mathes al.
Arthritis Rheumatol. 2015 Nov;67(11):3004-15. doi: 10.1002/art.39287.
Arthritis Rheumatol. 2015.
PMID: 26240058
Free PMC article.
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Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis.
van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M, York M, Collins C, Wenink M, Huijbens R, Hesselstrand R, Saxne T, DiMarzio M, Wuttge D, Agarwal SK, Reveille JD, Assassi S, Mayes M, Deng Y, Drenth JP, de Graaf J, den Heijer M, Kallenberg CG, Bijl M, Loof A, van den Berg WB, Joosten LA, Smith V, de Keyser F, Scorza R, Lunardi C, van Riel PL, Vonk M, van Heerde W, Meller S, Homey B, Beretta L, Roest M, Trojanowska M, Lafyatis R, Radstake TR.
van Bon L, et al. Among authors: mathes al.
N Engl J Med. 2014 Jan 30;370(5):433-43. doi: 10.1056/NEJMoa1114576. Epub 2013 Dec 18.
N Engl J Med. 2014.
PMID: 24350901
Free PMC article.
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Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients.
Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, Nakerakanti S, York M, Farina G, Whitfield ML, Spiera RF, Christmann RB, Gordon JK, Weinberg J, Simms RW, Lafyatis R.
Rice LM, et al.
J Clin Invest. 2015 Jul 1;125(7):2795-807. doi: 10.1172/JCI77958. Epub 2015 Jun 22.
J Clin Invest. 2015.
PMID: 26098215
Free PMC article.
Clinical Trial.
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