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NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA. Hou Y, et al. Among authors: mattson mp. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. doi: 10.1073/pnas.1718819115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432159 Free PMC article.
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
Sykora P, Misiak M, Wang Y, Ghosh S, Leandro GS, Liu D, Tian J, Baptiste BA, Cong WN, Brenerman BM, Fang E, Becker KG, Hamilton RJ, Chigurupati S, Zhang Y, Egan JM, Croteau DL, Wilson DM 3rd, Mattson MP, Bohr VA. Sykora P, et al. Among authors: mattson mp. Nucleic Acids Res. 2015 Jan;43(2):943-59. doi: 10.1093/nar/gku1356. Epub 2014 Dec 30. Nucleic Acids Res. 2015. PMID: 25552414 Free PMC article.
NAD+ in Aging: Molecular Mechanisms and Translational Implications.
Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA. Fang EF, et al. Among authors: mattson mp. Trends Mol Med. 2017 Oct;23(10):899-916. doi: 10.1016/j.molmed.2017.08.001. Epub 2017 Sep 9. Trends Mol Med. 2017. PMID: 28899755 Free PMC article. Review.
Mitochondrial DNA damage and repair in neurodegenerative disorders.
Yang JL, Weissman L, Bohr VA, Mattson MP. Yang JL, et al. Among authors: mattson mp. DNA Repair (Amst). 2008 Jul 1;7(7):1110-20. doi: 10.1016/j.dnarep.2008.03.012. Epub 2008 May 7. DNA Repair (Amst). 2008. PMID: 18463003 Free PMC article. Review.
980 results