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Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model.
Breast Cancer Res. 2019 Jan 22;21(1):9. doi: 10.1186/s13058-018-1092-x.
Breast Cancer Res. 2019.
PMID: 30670061
Free PMC article.
Safety, Antitumor Activity, and T-cell Responses in a Dose-Ranging Phase I Trial of the Oncolytic Peptide LTX-315 in Patients with Solid Tumors.
Spicer J, Marabelle A, Baurain JF, Jebsen NL, Jøssang DE, Awada A, Kristeleit R, Loirat D, Lazaridis G, Jungels C, Brunsvig P, Nicolaisen B, Saunders A, Patel H, Galon J, Hermitte F, Camilio KA, Mauseth B, Sundvold V, Sveinbjørnsson B, Rekdal Ø.
Spicer J, et al. Among authors: mauseth b.
Clin Cancer Res. 2021 May 15;27(10):2755-2763. doi: 10.1158/1078-0432.CCR-20-3435. Epub 2021 Feb 4.
Clin Cancer Res. 2021.
PMID: 33542073
Clinical Trial.
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Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer.
Fleten KG, Eksteen JJ, Mauseth B, Camilio KA, Vasskog T, Sveinbjørnsson B, Rekdal Ø, Mælandsmo GM, Flatmark K.
Fleten KG, et al. Among authors: mauseth b.
Sci Rep. 2021 Mar 24;11(1):6731. doi: 10.1038/s41598-021-86239-6.
Sci Rep. 2021.
PMID: 33762676
Free PMC article.
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The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma.
Mauseth B, Camilio KA, Shi J, Hammarström CL, Rekdal Ø, Sveinbjørnsson B, Line PD.
Mauseth B, et al.
Mol Ther Oncolytics. 2019 May 21;14:139-148. doi: 10.1016/j.omto.2019.05.002. eCollection 2019 Sep 27.
Mol Ther Oncolytics. 2019.
PMID: 31211244
Free PMC article.
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The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.
Eike LM, Mauseth B, Camilio KA, Rekdal Ø, Sveinbjørnsson B.
Eike LM, et al. Among authors: mauseth b.
PLoS One. 2016 Feb 16;11(2):e0148980. doi: 10.1371/journal.pone.0148980. eCollection 2016.
PLoS One. 2016.
PMID: 26881822
Free PMC article.
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Tumor lysis with LTX-401 creates anticancer immunity.
Xie W, Mondragón L, Mauseth B, Wang Y, Pol J, Lévesque S, Zhou H, Yamazaki T, Eksteen JJ, Zitvogel L, Sveinbjørnsson B, Rekdal Ø, Kepp O, Kroemer G.
Xie W, et al. Among authors: mauseth b.
Oncoimmunology. 2019 Apr 13;8(7):1594555. doi: 10.1080/2162402X.2019.1594555. eCollection 2019.
Oncoimmunology. 2019.
PMID: 31143516
Free PMC article.
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Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals.
Zhou H, Mondragón L, Xie W, Mauseth B, Leduc M, Sauvat A, Gomes-da-Silva LC, Forveille S, Iribarren K, Souquere S, Bezu L, Liu P, Zhao L, Zitvogel L, Sveinbjørnsson B, Eksteen JJ, Rekdal Ø, Kepp O, Kroemer G.
Zhou H, et al. Among authors: mauseth b.
Cell Death Dis. 2018 Oct 23;9(11):1086. doi: 10.1038/s41419-018-1127-3.
Cell Death Dis. 2018.
PMID: 30352991
Free PMC article.
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