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Chronic citalopram administration desensitizes prefrontal cortex but not somatodendritic α2-adrenoceptors in rat brain.
Fernández-Pastor B, Ortega JE, Grandoso L, Castro E, Ugedo L, Pazos Á, Meana JJ. Fernández-Pastor B, et al. Neuropharmacology. 2017 Mar 1;114:114-122. doi: 10.1016/j.neuropharm.2016.11.025. Epub 2016 Nov 28. Neuropharmacology. 2017. PMID: 27908769

.), administered to saline-treated animals (1 ml/kg i.p., 14 days) induced NA decrease in LC (E(max) = -44 4%; p < 0.001) and in PFC (E(max) = -61 5%, p < 0.001). In citalopram chronically-treated rats, clonidine administration exerted a lower decrease of NA (

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.), administered to saline-treated animals (1 ml/kg i.p., 14 days) induced NA decrease in LC (E(max) = -44 4%; p < 0.001) and in P

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α₂-Adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims.
Valdizán EM, Díez-Alarcia R, González-Maeso J, Pilar-Cuéllar F, García-Sevilla JA, Meana JJ, Pazos A. Valdizán EM, et al. Biol Psychiatry. 2010 Nov 1;68(9):869-72. doi: 10.1016/j.biopsych.2010.07.023. Epub 2010 Sep 22. Biol Psychiatry. 2010. PMID: 20864091 Free PMC article.

EC50 = 3.31 mumol/L; p < .01; depressed vs. control) and a significant reduction in the maximal inhibition of AC activity (I(max) = 27 4% vs. I(max) = 47 5%; p < .01) were observed after incubation with the alpha(2)-adrenoceptor agonist UK14304. ...A significa

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EC50 = 3.31 mumol/L; p < .01; depressed vs. control) and a significant reduction in the maximal inhibition of AC activity (I(max)

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Prevalence and clinical significance in our setting of incidental uptake in the thyroid gland found on 18F-fluordeoxyglucose positron emission tomography-computed tomography (PET-CT).
Familiar C, Merino S, Valhondo R, López C, Pérez X, De Los Monteros PE, Hernández F, Pazos M, Pallarés R, Pascual AC. Familiar C, et al. Endocrinol Diabetes Nutr (Engl Ed). 2023 Mar;70(3):171-178. doi: 10.1016/j.endien.2023.03.001. Endocrinol Diabetes Nutr (Engl Ed). 2023. PMID: 37030900
Sticholysins I and II interaction with cationic micelles promotes toxins' conformational changes and enhanced hemolytic activity.
Lanio ME, Alvarez C, Ochoa C, Ros U, Pazos F, Martínez D, Tejuca M, Eugenio LM, Casallanovo F, Dyszy FH, Schreier S, Lissi E. Lanio ME, et al. Toxicon. 2007 Nov;50(6):731-9. doi: 10.1016/j.toxicon.2007.06.007. Epub 2007 Jun 26. Toxicon. 2007. PMID: 17681582
Significant increases in the fluorescence intensity with a slightly red shift in lambda(max) were observed at concentrations close to the surfactants' CMC, suggesting changes in the environment of the tryptophan residues. ...
Significant increases in the fluorescence intensity with a slightly red shift in lambda(max) were observed at concentrations close to …