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N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity.
Dwoskin LP, Wooters TE, Sumithran SP, Siripurapu KB, Joyce BM, Lockman PR, Manda VK, Ayers JT, Zhang Z, Deaciuc AG, McIntosh JM, Crooks PA, Bardo MT. Dwoskin LP, et al. Among authors: mcintosh jm. J Pharmacol Exp Ther. 2008 Aug;326(2):563-76. doi: 10.1124/jpet.108.136630. Epub 2008 May 6. J Pharmacol Exp Ther. 2008. PMID: 18460644 Free PMC article.
Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release.
Smith AM, Pivavarchyk M, Wooters TE, Zhang Z, Zheng G, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. Smith AM, et al. Among authors: mcintosh jm. Biochem Pharmacol. 2010 Aug 1;80(3):402-9. doi: 10.1016/j.bcp.2010.03.018. Epub 2010 Mar 25. Biochem Pharmacol. 2010. PMID: 20346923 Free PMC article.
Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release.
Pivavarchyk M, Smith AM, Zhang Z, Zhou D, Wang X, Toyooka N, Tsuneki H, Sasaoka T, McIntosh JM, Crooks PA, Dwoskin LP. Pivavarchyk M, et al. Among authors: mcintosh jm. Eur J Pharmacol. 2011 May 11;658(2-3):132-9. doi: 10.1016/j.ejphar.2011.02.018. Epub 2011 Mar 1. Eur J Pharmacol. 2011. PMID: 21371454 Free PMC article.
Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.
Zheng G, Zhang Z, Dowell C, Wala E, Dwoskin LP, Holtman JR, McIntosh JM, Crooks PA. Zheng G, et al. Among authors: mcintosh jm. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2476-9. doi: 10.1016/j.bmcl.2011.02.043. Epub 2011 Feb 23. Bioorg Med Chem Lett. 2011. PMID: 21397497 Free PMC article.
327 results