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Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates.
Huntington's Disease Sheep Collaborative Research Group; Reid SJ, Patassini S, Handley RR, Rudiger SR, McLaughlan CJ, Osmand A, Jacobsen JC, Morton AJ, Weiss A, Waldvogel HJ, MacDonald ME, Gusella JF, Bawden CS, Faull RL, Snell RG. Huntington's Disease Sheep Collaborative Research Group, et al. Among authors: mclaughlan cj. J Huntingtons Dis. 2013;2(3):279-95. doi: 10.3233/JHD-130067. J Huntingtons Dis. 2013. PMID: 25062676
Metabolic disruption identified in the Huntington's disease transgenic sheep model.
Handley RR, Reid SJ, Patassini S, Rudiger SR, Obolonkin V, McLaughlan CJ, Jacobsen JC, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RL, Snell RG. Handley RR, et al. Among authors: mclaughlan cj. Sci Rep. 2016 Feb 11;6:20681. doi: 10.1038/srep20681. Sci Rep. 2016. PMID: 26864449 Free PMC article.
Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.
Handley RR, Reid SJ, Brauning R, Maclean P, Mears ER, Fourie I, Patassini S, Cooper GJS, Rudiger SR, McLaughlan CJ, Verma PJ, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RLM, Snell RG. Handley RR, et al. Among authors: mclaughlan cj. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11293-E11302. doi: 10.1073/pnas.1711243115. Epub 2017 Dec 11. Proc Natl Acad Sci U S A. 2017. PMID: 29229845 Free PMC article.
A Multi-Omic Huntington's Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis.
Mears ER, Handley RR, Grant MJ, Reid SJ, Day BT, Rudiger SR, McLaughlan CJ, Verma PJ, Bawden SC, Patassini S, Unwin RD, Cooper GJS, Gusella JF, MacDonald ME, Brauning R, Maclean P, Pearson JF, Waldvogel HJ, Faull RLM, Snell RG. Mears ER, et al. Among authors: mclaughlan cj. J Huntingtons Dis. 2021;10(4):423-434. doi: 10.3233/JHD-210482. J Huntingtons Dis. 2021. PMID: 34420978 Free PMC article.
An ovine transgenic Huntington's disease model.
Jacobsen JC, Bawden CS, Rudiger SR, McLaughlan CJ, Reid SJ, Waldvogel HJ, MacDonald ME, Gusella JF, Walker SK, Kelly JM, Webb GC, Faull RL, Rees MI, Snell RG. Jacobsen JC, et al. Among authors: mclaughlan cj. Hum Mol Genet. 2010 May 15;19(10):1873-82. doi: 10.1093/hmg/ddq063. Epub 2010 Feb 13. Hum Mol Genet. 2010. PMID: 20154343 Free PMC article.
Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration.
Chiang C, Jacobsen JC, Ernst C, Hanscom C, Heilbut A, Blumenthal I, Mills RE, Kirby A, Lindgren AM, Rudiger SR, McLaughlan CJ, Bawden CS, Reid SJ, Faull RL, Snell RG, Hall IM, Shen Y, Ohsumi TK, Borowsky ML, Daly MJ, Lee C, Morton CC, MacDonald ME, Gusella JF, Talkowski ME. Chiang C, et al. Among authors: mclaughlan cj. Nat Genet. 2012 Mar 4;44(4):390-7, S1. doi: 10.1038/ng.2202. Nat Genet. 2012. PMID: 22388000 Free PMC article.
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