McLean PJ - Search Results

1

Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).

Kalia LV, Kalia SK, Chau H, Lozano AM, Hyman BT, McLean PJ. Kalia LV, et al. Among authors: mclean pj. PLoS One. 2011 Feb 16;6(2):e14695. doi: 10.1371/journal.pone.0014695. PLoS One. 2011. PMID: 21358815 Free PMC article.

2

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.

Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ. Shin Y, et al. Among authors: mclean pj. J Biol Chem. 2005 Jun 24;280(25):23727-34. doi: 10.1074/jbc.M503326200. Epub 2005 Apr 21. J Biol Chem. 2005. PMID: 15845543 Free article.

3

Formation of toxic oligomeric alpha-synuclein species in living cells.

Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Outeiro TF, et al. Among authors: mclean pj. PLoS One. 2008 Apr 2;3(4):e1867. doi: 10.1371/journal.pone.0001867. PLoS One. 2008. PMID: 18382657 Free PMC article.

4

CHIP targets toxic alpha-Synuclein oligomers for degradation.

Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. Tetzlaff JE, et al. Among authors: mclean pj. J Biol Chem. 2008 Jun 27;283(26):17962-8. doi: 10.1074/jbc.M802283200. Epub 2008 Apr 24. J Biol Chem. 2008. PMID: 18436529 Free PMC article.

5

Dopamine-induced conformational changes in alpha-synuclein.

Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT. Outeiro TF, et al. Among authors: mclean pj. PLoS One. 2009 Sep 4;4(9):e6906. doi: 10.1371/journal.pone.0006906. PLoS One. 2009. PMID: 19730729 Free PMC article.

6

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics.

Dimant H, Zhu L, Kibuuka LN, Fan Z, Hyman BT, McLean PJ. Dimant H, et al. Among authors: mclean pj. PLoS One. 2014 Mar 24;9(3):e92098. doi: 10.1371/journal.pone.0092098. eCollection 2014. PLoS One. 2014. PMID: 24664141 Free PMC article.

7

An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.

McLean PJ, Hyman BT. McLean PJ, et al. Neurosci Lett. 2002 May 3;323(3):219-23. doi: 10.1016/s0304-3940(02)00154-4. Neurosci Lett. 2002. PMID: 11959424

8

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.

McLean PJ, Kawamata H, Shariff S, Hewett J, Sharma N, Ueda K, Breakefield XO, Hyman BT. McLean PJ, et al. J Neurochem. 2002 Nov;83(4):846-54. doi: 10.1046/j.1471-4159.2002.01190.x. J Neurochem. 2002. PMID: 12421356 Free article.

9

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.

Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ. Klucken J, et al. Among authors: mclean pj. J Biol Chem. 2004 Jun 11;279(24):25497-502. doi: 10.1074/jbc.M400255200. Epub 2004 Mar 25. J Biol Chem. 2004. PMID: 15044495 Free article.

10

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.

McLean PJ, Klucken J, Shin Y, Hyman BT. McLean PJ, et al. Biochem Biophys Res Commun. 2004 Aug 27;321(3):665-9. doi: 10.1016/j.bbrc.2004.07.021. Biochem Biophys Res Commun. 2004. PMID: 15358157

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