McLean S - Search Results

1

Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand.

Rosen T, Seeger TF, McLean S, Desai MC, Guarino KJ, Bryce D, Pratt K, Heym J, Chalabi PM, Windels JH, et al. Rosen T, et al. Among authors: mclean s. J Med Chem. 1993 Oct 15;36(21):3197-201. doi: 10.1021/jm00073a022. J Med Chem. 1993. PMID: 7693945

2

The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisst.

Lowe JA 3rd, Drozda SE, Snider RM, Longo KP, Zorn SH, Morrone J, Jackson ER, McLean S, Bryce DK, Bordner J, et al. Lowe JA 3rd, et al. Among authors: mclean s. J Med Chem. 1992 Jul 10;35(14):2591-600. doi: 10.1021/jm00092a009. J Med Chem. 1992. PMID: 1378901

3

Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist.

McLean S, Ganong AH, Seeger TF, Bryce DK, Pratt KG, Reynolds LS, Siok CJ, Lowe JA 3rd, Heym J. McLean S, et al. Science. 1991 Jan 25;251(4992):437-9. doi: 10.1126/science.1703324. Science. 1991. PMID: 1703324

4

Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists.

Rosen T, Nagel AA, Rizzi JP, Ives JL, Daffeh JB, Ganong AH, Guarino K, Heym J, McLean S, Nowakowski JT, et al. Rosen T, et al. Among authors: mclean s. J Med Chem. 1990 Oct;33(10):2715-20. doi: 10.1021/jm00172a006. J Med Chem. 1990. PMID: 2213824

5

Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole.

Rosen T, Seeger TF, McLean S, Nagel AA, Ives JL, Guarino KJ, Bryce D, Furman J, Roth RW, Chalabi PM, et al. Rosen T, et al. Among authors: mclean s. J Med Chem. 1990 Nov;33(11):3020-3. doi: 10.1021/jm00173a017. J Med Chem. 1990. PMID: 2231600

6

Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.

Nagel AA, Rosen T, Rizzi J, Daffeh J, Guarino K, Nowakowski J, Vincent LA, Heym J, McLean S, Seeger T, et al. Nagel AA, et al. Among authors: mclean s. J Med Chem. 1990 Jan;33(1):13-6. doi: 10.1021/jm00163a003. J Med Chem. 1990. PMID: 2296012 No abstract available.

7

Aza-tricyclic substance P antagonists.

Lowe JA 3rd, Drozda SE, McLean S, Bryce DK, Crawford RT, Snider RM, Longo KP, Nagahisa A, Tsuchiya M. Lowe JA 3rd, et al. Among authors: mclean s. J Med Chem. 1994 Sep 2;37(18):2831-40. doi: 10.1021/jm00044a002. J Med Chem. 1994. PMID: 7520943

8

Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor.

McLean S, Ganong A, Seymour PA, Snider RM, Desai MC, Rosen T, Bryce DK, Longo KP, Reynolds LS, Robinson G, et al. McLean S, et al. J Pharmacol Exp Ther. 1993 Oct;267(1):472-9. J Pharmacol Exp Ther. 1993. PMID: 7693914

9

CP-99,994, a nonpeptide antagonist of the tachykinin NK1 receptor.

McLean S, Snider RM, Desai MC, Rosen T, Bryce DK, Longo KP, Schmidt AW, Heym J. McLean S, et al. Regul Pept. 1993 Jul 2;46(1-2):329-31. doi: 10.1016/0167-0115(93)90075-j. Regul Pept. 1993. PMID: 8210497 No abstract available.

10

Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor.

McLean S, Ganong A, Seymour PA, Bryce DK, Crawford RT, Morrone J, Reynolds LS, Schmidt AW, Zorn S, Watson J, Fossa A, DePasquale M, Rosen T, Nagahisa A, Tsuchiya M, Heym J. McLean S, et al. J Pharmacol Exp Ther. 1996 May;277(2):900-8. J Pharmacol Exp Ther. 1996. PMID: 8627572

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