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Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Cheung-Lee WL, Kolev JN, McIntosh JA, Gil AA, Pan W, Xiao L, Velásquez JE, Gangam R, Winston MS, Li S, Abe K, Alwedi E, Dance ZEX, Fan H, Hiraga K, Kim J, Kosjek B, Le DN, Marzijarani NS, Mattern K, McMullen JP, Narsimhan K, Vikram A, Wang W, Yan JX, Yang RS, Zhang V, Zhong W, DiRocco DA, Morris WJ, Murphy GS, Maloney KM. Cheung-Lee WL, et al. Among authors: mcmullen jp. Angew Chem Int Ed Engl. 2024 Mar 22;63(13):e202316133. doi: 10.1002/anie.202316133. Epub 2024 Feb 19. Angew Chem Int Ed Engl. 2024. PMID: 38279624
A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology.
Weeks KL, Kiriazis H, Wadley GD, Masterman EI, Sergienko NM, Raaijmakers AJA, Trewin AJ, Harmawan CA, Yildiz GS, Liu Y, Drew BG, Gregorevic P, Delbridge LMD, McMullen JR, Bernardo BC. Weeks KL, et al. Among authors: mcmullen jr. J Mol Med (Berl). 2024 Jan;102(1):95-111. doi: 10.1007/s00109-023-02397-2. Epub 2023 Nov 21. J Mol Med (Berl). 2024. PMID: 37987775
268 results