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Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms.
Roberts I, Edwards P, Prieto D, Joshi M, Mahmood A, Ker K, Shakur H. Roberts I, et al. Trials. 2017 Jan 31;18(1):48. doi: 10.1186/s13063-016-1750-1. Trials. 2017. PMID: 28143564 Free PMC article. Clinical Trial.
BACKGROUND: The CRASH-2 trial showed that tranexamic acid (TXA) administration reduces mortality in bleeding trauma patients. ...METHODS: Exploratory analysis were carried out, including per-protocol analyses, …
BACKGROUND: The CRASH-2 trial showed that tranexamic acid (TXA) administration reduces mortality in bl …
Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial.
Roberts I, Prieto-Merino D, Manno D. Roberts I, et al. Crit Care. 2014 Dec 13;18(6):685. doi: 10.1186/s13054-014-0685-8. Crit Care. 2014. PMID: 25498484 Free PMC article. Clinical Trial.
INTRODUCTION: To investigate the mechanism of action of tranexamic acid (TXA) in bleeding trauma patients, we examined the timing of its effect on mortality. ...METHODS: Exploratory analysis, including per-prot …
INTRODUCTION: To investigate the mechanism of action of tranexamic acid (TXA) in bleeding traum …
Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.
Brenner A, Belli A, Chaudhri R, Coats T, Frimley L, Jamaluddin SF, Jooma R, Mansukhani R, Sandercock P, Shakur-Still H, Shokunbi T, Roberts I; CRASH-3 trial collaborators. Brenner A, et al. Crit Care. 2020 Nov 11;24(1):560. doi: 10.1186/s13054-020-03243-4. Crit Care. 2020. PMID: 33172504 Free PMC article. Clinical Trial.
BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). ...We pool data from the CRASH-2 and CRASH-3 trials in …
BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracr …
The Effect of Tranexamic Acid on Functional Outcomes: An Exploratory Analysis of the CRASH-2 Randomized Controlled Trial.
Nishijima DK, Kuppermann N, Roberts I, VanBuren JM, Tancredi DJ. Nishijima DK, et al. Ann Emerg Med. 2019 Jul;74(1):79-87. doi: 10.1016/j.annemergmed.2018.11.018. Epub 2019 Jan 12. Ann Emerg Med. 2019. PMID: 30642657 Clinical Trial.
We hypothesized that tranexamic acid improves overall functional outcome compared with placebo in severely injured adults and conduct an exploratory analysis of the Clinical Randomization of an Antifibrinolytic in Significant Haemorrhage (CRA …
We hypothesized that tranexamic acid improves overall functional outcome compared with placebo in severely injured adults and …