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Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders.
Peters S, Wirkert E, Kuespert S, Heydn R, Johannesen S, Friedrich A, Mailänder S, Korte S, Mecklenburg L, Aigner L, Bruun TH, Bogdahn U. Peters S, et al. Among authors: mecklenburg l. Pharmaceutics. 2022 Jan 15;14(1):200. doi: 10.3390/pharmaceutics14010200. Pharmaceutics. 2022. PMID: 35057094 Free PMC article.
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis).
Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, Ernst R, van Esch E, Everitt J, Fant P, Gruebbel MM, Mecklenburg L, Miller AD, Nikula KJ, Satake S, Schwartz J, Sharma A, Shimoi A, Sobry C, Taylor I, Vemireddi V, Vidal J, Wood C, Vahle JL. Colman K, et al. Among authors: mecklenburg l. J Toxicol Pathol. 2021;34(3 Suppl):1S-182S. doi: 10.1293/tox.34.1S. Epub 2021 Sep 28. J Toxicol Pathol. 2021. PMID: 34712008 Free PMC article. Review.
Naked (N) mutant mice carry a nonsense mutation in the homeobox of Hoxc13.
Perez CJ, Mecklenburg L, Fernandez A, Cantero M, de Souza TA, Lin K, Dent SYR, Montoliu L, Awgulewitsch A, Benavides F. Perez CJ, et al. Among authors: mecklenburg l. Exp Dermatol. 2022 Mar;31(3):330-340. doi: 10.1111/exd.14469. Epub 2021 Oct 25. Exp Dermatol. 2022. PMID: 34657330
Research Relevant Conditions and Pathology in Nonhuman Primates.
Saravanan C, Flandre T, Hodo CL, Lewis AD, Mecklenburg L, Romeike A, Turner OC, Yen HY. Saravanan C, et al. Among authors: mecklenburg l. ILAR J. 2020 Dec 31;61(2-3):139-166. doi: 10.1093/ilar/ilab017. ILAR J. 2020. PMID: 34129672 Free PMC article. Review.
Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling.
Peters S, Kuespert S, Wirkert E, Heydn R, Jurek B, Johannesen S, Hsam O, Korte S, Ludwig FT, Mecklenburg L, Mrowetz H, Altendorfer B, Poupardin R, Petri S, Thal DR, Hermann A, Weishaupt JH, Weis J, Aksoylu IS, Lewandowski SA, Aigner L, Bruun TH, Bogdahn U. Peters S, et al. Among authors: mecklenburg l. Neurotherapeutics. 2021 Jul;18(3):1963-1979. doi: 10.1007/s13311-021-01045-2. Epub 2021 Apr 15. Neurotherapeutics. 2021. PMID: 33860461 Free PMC article.
Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys.
Korte S, Luft J, von Keutz A, Runge F, Mecklenburg L, Wozniak MM, Zander S, Ludwig FT, Pajaziti B, Romeike A, Korytko P. Korte S, et al. Among authors: mecklenburg l. Int J Toxicol. 2020 Nov/Dec;39(6):510-517. doi: 10.1177/1091581820951098. Epub 2020 Aug 28. Int J Toxicol. 2020. PMID: 32856507
45 results