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84 results

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Page 1
Serum metabolomic profiling reveals potential biomarkers in systemic sclerosis.
Guo M, Liu D, Jiang Y, Chen W, Zhao L, Bao D, Li Y, Distler JHW, Zhu H. Guo M, et al. Metabolism. 2023 Jul;144:155587. doi: 10.1016/j.metabol.2023.155587. Epub 2023 May 6. Metabolism. 2023. PMID: 37156409
Specific metabolites identified by ML algorithms, such as medicagenic acid 3-O-b-D-glucuronide, 4'-O-methyl-(-)-epicatechin-3'-O-beta-glucuronide, valproic acid glucuronide, have the potential to predict the progression of skin fibrosis. ...
Specific metabolites identified by ML algorithms, such as medicagenic acid 3-O-b-D-glucuronide, 4'-O-methyl-(-)-epicatechin-3' …
Effects of medicagenic acid metabolites, originating from biotransformation of an Herniaria hirsuta extract, on calcium oxalate crystallization in vitro.
Peeters L, Foubert K, Breynaert A, Schreurs G, Verhulst A, Pieters L, Hermans N. Peeters L, et al. J Ethnopharmacol. 2022 Mar 1;285:114860. doi: 10.1016/j.jep.2021.114860. Epub 2021 Nov 22. J Ethnopharmacol. 2022. PMID: 34822955
AIM OF THE STUDY: A sample of hepatic metabolites of medicagenic acid, with medicagenic acid glucuronide as the most abundant one, was evaluated for in vitro activity against urinary stones. ...CONCLUSIONS: As both formation of crystals by inhibiting a …
AIM OF THE STUDY: A sample of hepatic metabolites of medicagenic acid, with medicagenic acid glucuronide as the …
Triterpenic saponins from Medicago marina L.
Tava A, Biazzi E, Ronga D, Mella M, Doria F, Accogli R, Argentieri MP, Avato P. Tava A, et al. Phytochemistry. 2020 Jun;174:112333. doi: 10.1016/j.phytochem.2020.112333. Epub 2020 Mar 21. Phytochemistry. 2020. PMID: 32208199
Saponins as antimycotic agents: glycosides of medicagenic acid.
Zehavi U, Polacheck I. Zehavi U, et al. Adv Exp Med Biol. 1996;404:535-46. doi: 10.1007/978-1-4899-1367-8_44. Adv Exp Med Biol. 1996. PMID: 8957322 Review.
The concern with increased resistance due to widespread and prolonged antifungal treatment, particularly with azoles, is noteworthy. Our efforts were focused on medicagenic acid derivatives isolated from alfalfa and on semisynthetic ones. ...Furthermore, they were f …
The concern with increased resistance due to widespread and prolonged antifungal treatment, particularly with azoles, is noteworthy. Our eff …
Reinvestigation of Herniaria glabra L. saponins and their biological activity.
Kozachok S, Pecio Ł, Orhan IE, Deniz FSS, Marchyshyn S, Oleszek W. Kozachok S, et al. Phytochemistry. 2020 Jan;169:112162. doi: 10.1016/j.phytochem.2019.112162. Epub 2019 Oct 15. Phytochemistry. 2020. PMID: 31627115
Twelve undescribed triterpenoid pentacyclic glycosides, medicagenic acid (3-O-beta-D-glucuronopyranosyl-28-O-{[beta-D-glucopyranosyl-(1 3)-alpha-L-rhamnopyranosyl-(1 2)]-[alpha-L-rhamnopyranosyl-(1 3)]-4-O-acetyl-beta-D-fucopyranosyl-(1)}-2beta,3beta-dihydroxyolean- …
Twelve undescribed triterpenoid pentacyclic glycosides, medicagenic acid (3-O-beta-D-glucuronopyranosyl-28-O-{[beta-D-glucopyr …
Medicagenic acid saponins from Aster batangensis.
Shao Y, Zhou B, Ma K, Wu H, Lin L, Cordell GA. Shao Y, et al. Phytochemistry. 1995 Jul;39(4):875-81. doi: 10.1016/0031-9422(95)00016-z. Phytochemistry. 1995. PMID: 7626267
Two new medicagenic acid saponins, named asterbatanoside J and K, were isolated from the roots of Aster batangensis. On the basis of chemical and spectral studies especially 2D NMR including COSY, HETCOR, HMQC, HOHAHA, TOCSY, ROESY and HMBC techniques, their structu …
Two new medicagenic acid saponins, named asterbatanoside J and K, were isolated from the roots of Aster batangensis. On the ba …
Chemistry and biological activity of triterpenoid glycosides from Medicago sativa.
Timbekova AE, Isaev MI, Abubakirov NK. Timbekova AE, et al. Adv Exp Med Biol. 1996;405:171-82. doi: 10.1007/978-1-4613-0413-5_14. Adv Exp Med Biol. 1996. PMID: 8910703 Review.
(Leguminosae) including eight new glycosides and two previously known, medicagenic acid 3-O-beta-D-glucopyranoside and hederagenin 3-O-[beta-D-glucopyranosyl(1-->2)-alpha-L-arabinopyranoside]. Four new saponins were identified as glycosides of medicagenic …
(Leguminosae) including eight new glycosides and two previously known, medicagenic acid 3-O-beta-D-glucopyranoside and hederag …
A comparative study on the in vitro biotransformation of medicagenic acid using human liver microsomes and S9 fractions.
Peeters L, Vervliet P, Foubert K, Hermans N, Pieters L, Covaci A. Peeters L, et al. Chem Biol Interact. 2020 Sep 1;328:109192. doi: 10.1016/j.cbi.2020.109192. Epub 2020 Jul 23. Chem Biol Interact. 2020. PMID: 32712081
This study compares two widely used in vitro models for hepatic biotransformation: 1) human S9 fractions and 2) human liver microsomes and cytosolic fractions in a two-step sequence, with the purpose of identifying differences in the biotransformation of medicagenic aci …
This study compares two widely used in vitro models for hepatic biotransformation: 1) human S9 fractions and 2) human liver microsomes and c …
Saponins from the roots of Chenopodium bonus-henricus L.
Kokanova-Nedialkova Z, Nedialkov PT, Momekov G. Kokanova-Nedialkova Z, et al. Nat Prod Res. 2019 Jul;33(14):2024-2031. doi: 10.1080/14786419.2018.1483928. Epub 2018 Jun 8. Nat Prod Res. 2019. PMID: 29882435
Two new glycosides of phytolaccagenin and 2beta-hydroxyoleanoic acid, namely bonushenricoside A (3) and bonushenricoside B (5) together with four known saponins, respectively compounds 3-O-L-alpha-arabinopyranosyl-bayogenin-28-O-beta-glucopyranosyl ester (1), 3-O-beta-glucuronopy …
Two new glycosides of phytolaccagenin and 2beta-hydroxyoleanoic acid, namely bonushenricoside A (3) and bonushenricoside B (5) together with …
Acylated oleanane-type saponins from Ganophyllum giganteum.
Montes EG, Mitaine-Offer AC, Amaro-Luis JM, Paululat T, Delaude C, Pouységu L, Quideau S, Rojas LB, Delemasure S, Dutartre P, Lacaille-Dubois MA. Montes EG, et al. Phytochemistry. 2014 Feb;98:236-42. doi: 10.1016/j.phytochem.2013.11.003. Epub 2013 Dec 30. Phytochemistry. 2014. PMID: 24388676
Five oleanane-type saponins, 3-O-beta-D-glucuronopyranosylzanhic acid 28-O-beta-D-xylopyranosyl-(13)-[alpha-L-rhamnopyranosyl-(12)]-(4-O-acetyl)-beta-D-fucopyranosyl ester (1), 3-O-beta-D-glucopyranosylzanhic acid 28-O-beta-D-xylopyranosyl-(13)-[alpha-L-rhamnopyranosyl-(12)]-(4-O …
Five oleanane-type saponins, 3-O-beta-D-glucuronopyranosylzanhic acid 28-O-beta-D-xylopyranosyl-(13)-[alpha-L-rhamnopyranosyl-(12)]-(4-O-ace …
84 results