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CVID-associated TACI mutations affect autoreactive B cell selection and activation.
Romberg N, Chamberlain N, Saadoun D, Gentile M, Kinnunen T, Ng YS, Virdee M, Menard L, Cantaert T, Morbach H, Rachid R, Martinez-Pomar N, Matamoros N, Geha R, Grimbacher B, Cerutti A, Cunningham-Rundles C, Meffre E. Romberg N, et al. Among authors: meffre e. J Clin Invest. 2013 Oct;123(10):4283-93. doi: 10.1172/JCI69854. Epub 2013 Sep 24. J Clin Invest. 2013. PMID: 24051380 Free PMC article.
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88.
He B, Santamaria R, Xu W, Cols M, Chen K, Puga I, Shan M, Xiong H, Bussel JB, Chiu A, Puel A, Reichenbach J, Marodi L, Döffinger R, Vasconcelos J, Issekutz A, Krause J, Davies G, Li X, Grimbacher B, Plebani A, Meffre E, Picard C, Cunningham-Rundles C, Casanova JL, Cerutti A. He B, et al. Among authors: meffre e. Nat Immunol. 2010 Sep;11(9):836-45. doi: 10.1038/ni.1914. Epub 2010 Aug 1. Nat Immunol. 2010. PMID: 20676093 Free PMC article.
Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans.
Meyers G, Ng YS, Bannock JM, Lavoie A, Walter JE, Notarangelo LD, Kilic SS, Aksu G, Debré M, Rieux-Laucat F, Conley ME, Cunningham-Rundles C, Durandy A, Meffre E. Meyers G, et al. Among authors: meffre e. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11554-9. doi: 10.1073/pnas.1102600108. Epub 2011 Jun 23. Proc Natl Acad Sci U S A. 2011. PMID: 21700883 Free PMC article.
131 results