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Page 1
Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.
Tsilidis KK, Papadimitriou N, Dimou N, Gill D, Lewis SJ, Martin RM, Murphy N, Markozannes G, Zuber V, Cross AJ, Burrows K, Lopez DS, Key TJ, Travis RC, Perez-Cornago A, Hunter DJ, van Duijnhoven FJB, Albanes D, Arndt V, Berndt SI, Bézieau S, Bishop DT, Boehm J, Brenner H, Burnett-Hartman A, Campbell PT, Casey G, Castellví-Bel S, Chan AT, Chang-Claude J, de la Chapelle A, Figueiredo JC, Gallinger SJ, Giles GG, Goodman PJ, Gsur A, Hampe J, Hampel H, Hoffmeister M, Jenkins MA, Keku TO, Kweon SS, Larsson SC, Le Marchand L, Li CI, Li L, Lindblom A, Martín V, Milne RL, Moreno V, Nan H, Nassir R, Newcomb PA, Offit K, Pharoah PDP, Platz EA, Potter JD, Qi L, Rennert G, Sakoda LC, Schafmayer C, Slattery ML, Snetselaar L, Schenk J, Thibodeau SN, Ulrich CM, Van Guelpen B, Harlid S, Visvanathan K, Vodickova L, Wang H, White E, Wolk A, Woods MO, Wu AH, Zheng W, Bueno-de-Mesquita B, Boutron-Ruault MC, Hughes DJ, Jakszyn P, Kühn T, Palli D, Riboli E, Giovannucci EL, Banbury BL, Gruber SB, Peters U, Gunter MJ. Tsilidis KK, et al. Am J Clin Nutr. 2021 Jun 1;113(6):1490-1502. doi: 10.1093/ajcn/nqab003. Am J Clin Nutr. 2021. PMID: 33740060 Free PMC article.
RESULTS: Nominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95% CI: 1.00, 1.17; P value = 0.05] and similarly for proximal colon cancer, and for vitamin B-12 concentrat …
RESULTS: Nominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ …
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors.
Bellail AC, Jin HR, Lo HY, Jung SH, Hamdouchi C, Kim D, Higgins RK, Blanck M, le Sage C, Cross BCS, Li J, Mosley AL, Wijeratne AB, Jiang W, Ghosh M, Zhao YQ, Hauck PM, Shekhar A, Hao C. Bellail AC, et al. Sci Transl Med. 2021 Oct 13;13(615):eabh1486. doi: 10.1126/scitranslmed.abh1486. Epub 2021 Oct 13. Sci Transl Med. 2021. PMID: 34644148 Free PMC article.
Systemic administration of HB007 inhibited the progression of patient-derived brain, breast, colon, and lung cancers in mice and increased survival of the animals. ...
Systemic administration of HB007 inhibited the progression of patient-derived brain, breast, colon, and lung cancers in mice and incr …
Machine Learning Predicts Oxaliplatin Benefit in Early Colon Cancer.
Chen L, Wang Y, Cai C, Ding Y, Kim RS, Lipchik C, Gavin PG, Yothers G, Allegra CJ, Petrelli NJ, Suga JM, Hopkins JO, Saito NG, Evans T, Jujjavarapu S, Wolmark N, Lucas PC, Paik S, Sun M, Pogue-Geile KL, Lu X. Chen L, et al. J Clin Oncol. 2024 May 1;42(13):1520-1530. doi: 10.1200/JCO.23.01080. Epub 2024 Feb 5. J Clin Oncol. 2024. PMID: 38315963
PURPOSE: A combination of fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is the standard for adjuvant therapy of resected early-stage colon cancer (CC). Oxaliplatin leads to lasting and disabling neurotoxicity. ...METHODS: We trained a new machine learning model, refer …
PURPOSE: A combination of fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is the standard for adjuvant therapy of resected early-stage …
DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis.
Maiuri AR, Savant SS, Podicheti R, Rusch DB, O'Hagan HM. Maiuri AR, et al. Epigenetics. 2019 Dec;14(12):1209-1223. doi: 10.1080/15592294.2019.1634986. Epub 2019 Jun 26. Epigenetics. 2019. PMID: 31240997 Free PMC article.
Chronic inflammation is also associated with DNA methylation alterations and in a mouse model of inflammation-induced colon tumorigenesis, we previously demonstrated that inflammation-induced tumours have 203 unique regions with DNA hypermethylation compared to uninflamed …
Chronic inflammation is also associated with DNA methylation alterations and in a mouse model of inflammation-induced colon tumorigen …
Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene.
Allen J, Rosendahl Huber A, Pleguezuelos-Manzano C, Puschhof J, Wu S, Wu X, Boot C, Saftien A, O'Hagan HM, Wang H, van Boxtel R, Clevers H, Sears CL. Allen J, et al. Microbiol Spectr. 2022 Jun 29;10(3):e0105522. doi: 10.1128/spectrum.01055-22. Epub 2022 May 19. Microbiol Spectr. 2022. PMID: 35587635 Free PMC article.
Both human and mouse models have established a strong association between particular microbes and colon tumor induction. However, the genetic mechanisms underlying putative microbe-induced colon tumor formation are not well established. In this paper, we applied who …
Both human and mouse models have established a strong association between particular microbes and colon tumor induction. However, the …
Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.
DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL. DeStefano Shields CE, et al. J Infect Dis. 2016 Jul 1;214(1):122-9. doi: 10.1093/infdis/jiw069. Epub 2016 Feb 21. J Infect Dis. 2016. PMID: 26908749 Free PMC article.
BACKGROUND: Chronic inflammation and composition of the colon microbiota have been associated with colorectal cancer in humans. ...CONCLUSIONS: The timing of ETBF clearance profoundly influences colon adenoma formation, defining a period during which the colon …
BACKGROUND: Chronic inflammation and composition of the colon microbiota have been associated with colorectal cancer in humans. ...CO …
The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases.
Griesenauer B, Paczesny S. Griesenauer B, et al. Front Immunol. 2017 Apr 24;8:475. doi: 10.3389/fimmu.2017.00475. eCollection 2017. Front Immunol. 2017. PMID: 28484466 Free PMC article. Review.
ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a decoy receptor, sequesters free IL-33, and does not signal, and a membrane-bound form (ST2), which activates the MyD88/NF-kappaB signaling pathway to enhance mast cell, Th2, regulatory T cell (Treg …
ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a decoy receptor, sequesters free IL-33, and does not signa …
"Supercharged" isoperistaltic colon interposition for long-segment esophageal reconstruction.
Kesler KA, Pillai ST, Birdas TJ, Rieger KM, Okereke IC, Ceppa D, Socas J, Starnes SL. Kesler KA, et al. Ann Thorac Surg. 2013 Apr;95(4):1162-8; discussion 1168-9. doi: 10.1016/j.athoracsur.2013.01.006. Epub 2013 Feb 21. Ann Thorac Surg. 2013. PMID: 23434255
BACKGROUND: When the stomach is not available, long-segment esophageal reconstruction remains a surgical challenge. Since 2005, we have used a "supercharged" isoperistaltic colon interposition conduit for long-segment esophageal reconstruction that reestablishes a dual blo …
BACKGROUND: When the stomach is not available, long-segment esophageal reconstruction remains a surgical challenge. Since 2005, we have used …
Metformin Bicarbonate-Mediated Efficient RNAi for Precise Targeting of TP53 Deficiency in Colon and Rectal Cancers.
Xu J, Liu Y, Liu S, Ou W, White A, Stewart S, Tkaczuk KHR, Ellis LM, Wan J, Lu X, He X. Xu J, et al. Nano Today. 2022 Apr;43:101406. doi: 10.1016/j.nantod.2022.101406. Epub 2022 Feb 1. Nano Today. 2022. PMID: 35251293 Free PMC article.
Colon and rectal cancers are the leading causes of cancer-related deaths in the United States and effective targeted therapies are in need for treating them. Our genomic analyses show hemizygous deletion of TP53, an important tumor suppressor gene, is highly frequent in bo …
Colon and rectal cancers are the leading causes of cancer-related deaths in the United States and effective targeted therapies are in …
Genetic Alterations of NF-κB and Its Regulators: A Rich Platform to Advance Colorectal Cancer Diagnosis and Treatment.
Alipourgivi F, Motolani A, Qiu AY, Qiang W, Yang GY, Chen S, Lu T. Alipourgivi F, et al. Int J Mol Sci. 2023 Dec 21;25(1):154. doi: 10.3390/ijms25010154. Int J Mol Sci. 2023. PMID: 38203325 Free PMC article. Review.
., PDX or organoids, or isogenic human embryonic stem cell (hESC)-derived colonic cells, or human pluripotent stem cells (hPSC)-derived colonic organoids, etc.) to further uncover the underpinning mechanism of these genetic alterations in NF-kappaB signaling in CRC …
., PDX or organoids, or isogenic human embryonic stem cell (hESC)-derived colonic cells, or human pluripotent stem cells (hPSC)-deriv …
59 results