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Biased modulators of NMDA receptors control channel opening and ion selectivity.
Perszyk RE, Swanger SA, Shelley C, Khatri A, Fernandez-Cuervo G, Epplin MP, Zhang J, Le P, Bülow P, Garnier-Amblard E, Gangireddy PKR, Bassell GJ, Yuan H, Menaldino DS, Liotta DC, Liebeskind LS, Traynelis SF. Perszyk RE, et al. Among authors: menaldino ds. Nat Chem Biol. 2020 Feb;16(2):188-196. doi: 10.1038/s41589-019-0449-5. Epub 2020 Jan 20. Nat Chem Biol. 2020. PMID: 31959964 Free PMC article.
Fumonisin toxicity and sphingolipid biosynthesis.
Merrill AH Jr, Wang E, Vales TR, Smith ER, Schroeder JJ, Menaldino DS, Alexander C, Crane HM, Xia J, Liotta DC, Meredith FI, Riley RT. Merrill AH Jr, et al. Among authors: menaldino ds. Adv Exp Med Biol. 1996;392:297-306. doi: 10.1007/978-1-4899-1379-1_25. Adv Exp Med Biol. 1996. PMID: 8850625 Review.
Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer.
Garnier-Amblard EC, Mays SG, Arrendale RF, Baillie MT, Bushnev AS, Culver DG, Evers TJ, Holt JJ, Howard RB, Liebeskind LS, Menaldino DS, Natchus MG, Petros JA, Ramaraju H, Reddy GP, Liotta DC. Garnier-Amblard EC, et al. Among authors: menaldino ds. ACS Med Chem Lett. 2011 Mar 25;2(6):438-43. doi: 10.1021/ml2000164. eCollection 2011 Jun 9. ACS Med Chem Lett. 2011. PMID: 24900327 Free PMC article.
The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.
Strong KL, Epplin MP, Bacsa J, Butch CJ, Burger PB, Menaldino DS, Traynelis SF, Liotta DC. Strong KL, et al. Among authors: menaldino ds. J Med Chem. 2017 Jul 13;60(13):5556-5585. doi: 10.1021/acs.jmedchem.7b00239. Epub 2017 Jun 26. J Med Chem. 2017. PMID: 28586221 Free PMC article.
A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.
Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF. Swanger SA, et al. Among authors: menaldino ds. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. doi: 10.1021/acschemneuro.7b00329. Epub 2017 Nov 2. ACS Chem Neurosci. 2018. PMID: 29043770 Free PMC article.
The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor.
Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB. Kaiser TM, et al. Among authors: menaldino ds. Mol Pharmacol. 2018 Feb;93(2):141-156. doi: 10.1124/mol.117.110940. Epub 2017 Dec 14. Mol Pharmacol. 2018. PMID: 29242355 Free PMC article.
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