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Zibotentan in combination with dapagliflozin compared with dapagliflozin in patients with chronic kidney disease (ZENITH-CKD): a multicentre, randomised, active-controlled, phase 2b, clinical trial.
Lancet. 2023 Nov 25;402(10416):2004-2017. doi: 10.1016/S0140-6736(23)02230-4. Epub 2023 Nov 3.
Lancet. 2023.
PMID: 37931629
Clinical Trial.
Efficacy and safety of zibotentan and dapagliflozin in patients with chronic kidney disease: study design and baseline characteristics of the ZENITH-CKD trial.
Heerspink HJL, Greasley PJ, Ahlström C, Althage M, Dwyer JP, Law G, Wijkmark E, Lin M, Mercier AK, Sunnåker M, Turton M, Wheeler DC, Ambery P.
Heerspink HJL, et al. Among authors: mercier ak.
Nephrol Dial Transplant. 2024 Feb 28;39(3):414-425. doi: 10.1093/ndt/gfad183.
Nephrol Dial Transplant. 2024.
PMID: 37632201
Free PMC article.
Clinical Trial.
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Pharmacokinetics and Tolerability of Zibotentan in Patients with Concurrent Moderate Renal and Moderate Hepatic Impairment.
Mercier AK, Sunnåker M, Ueckert S, Pawlik T, Henricson E, Molodetskyi O, Law GC, Parker VER, Oscarsson J.
Mercier AK, et al.
Clin Pharmacokinet. 2023 Dec;62(12):1713-1724. doi: 10.1007/s40262-023-01306-7. Epub 2023 Oct 6.
Clin Pharmacokinet. 2023.
PMID: 37801266
Free PMC article.
Item in Clipboard
Zibotentan Can Be Co-administered with Contraceptives Containing Ethinyl Estradiol and Levonorgestrel: A Pharmacokinetic Drug-Drug Interaction Study.
Mercier AK, Kois AK, Karsanji D, Baldry R, Birve F, Hedwall M, Molodetskyi O, Gillen M.
Mercier AK, et al.
Clin Pharmacol Ther. 2024 Apr 30. doi: 10.1002/cpt.3280. Online ahead of print.
Clin Pharmacol Ther. 2024.
PMID: 38686600
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Long-term safety of brazikumab in the open-label period of a randomized phase 2a study of patients with Crohn's disease.
Danese S, Beaton A, Duncan EA, Mercier AK, Neisen J, Seth H, Zetterstrand S, Sands BE.
Danese S, et al. Among authors: mercier ak.
BMC Gastroenterol. 2023 Dec 20;23(1):451. doi: 10.1186/s12876-023-03078-7.
BMC Gastroenterol. 2023.
PMID: 38124112
Free PMC article.
Clinical Trial.
Item in Clipboard
AZD5634, an inhaled ENaC inhibitor, in healthy subjects and patients with cystic fibrosis.
Kristensson C, Åstrand A, Donaldson S, Goldwater R, Abdulai R, Patel N, Gardiner P, Tehler U, Mercier AK, Olsson M, Ersdal E, Mäenpää J, Bramer T, Malmgren A, Bennett W, Keen C.
Kristensson C, et al. Among authors: mercier ak.
J Cyst Fibros. 2022 Jul;21(4):684-690. doi: 10.1016/j.jcf.2022.02.010. Epub 2022 Feb 26.
J Cyst Fibros. 2022.
PMID: 35227647
Free article.
Clinical Trial.
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