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The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.
Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E. Schröder R, et al. Among authors: merten n. J Biol Chem. 2009 Jan 9;284(2):1324-36. doi: 10.1074/jbc.M806867200. Epub 2008 Nov 14. J Biol Chem. 2009. PMID: 19010788 Free article.
An experimental strategy to probe Gq contribution to signal transduction in living cells.
Patt J, Alenfelder J, Pfeil EM, Voss JH, Merten N, Eryilmaz F, Heycke N, Rick U, Inoue A, Kehraus S, Deupi X, Müller CE, König GM, Crüsemann M, Kostenis E. Patt J, et al. Among authors: merten n. J Biol Chem. 2021 Jan-Jun;296:100472. doi: 10.1016/j.jbc.2021.100472. Epub 2021 Feb 25. J Biol Chem. 2021. PMID: 33639168 Free PMC article.
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling.
Bock A, Merten N, Schrage R, Dallanoce C, Bätz J, Klöckner J, Schmitz J, Matera C, Simon K, Kebig A, Peters L, Müller A, Schrobang-Ley J, Tränkle C, Hoffmann C, De Amici M, Holzgrabe U, Kostenis E, Mohr K. Bock A, et al. Among authors: merten n. Nat Commun. 2012;3:1044. doi: 10.1038/ncomms2028. Nat Commun. 2012. PMID: 22948826 Free PMC article.
The experimental power of FR900359 to study Gq-regulated biological processes.
Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E. Schrage R, et al. Among authors: merten n. Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156. Nat Commun. 2015. PMID: 26658454 Free PMC article.
66 results