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A comprehensive two-hybrid analysis to explore the Legionella pneumophila effector-effector interactome.
Mount HO, Urbanus ML, Sheykhkarimli D, Coté AG, Laval F, Coppin G, Kishore N, Li R, Spirohn-Fitzgerald K, Petersen MO, Knapp JJ, Kim D-K, Twizere J-C, Calderwood MA, Vidal M, Roth FP, Ensminger AW. Mount HO, et al. mSystems. 2024 Dec 17;9(12):e0100424. doi: 10.1128/msystems.01004-24. Epub 2024 Nov 11. mSystems. 2024. PMID: 39526800 Free PMC article.
A defining feature of metaeffectors is direct, physical interaction with a target effector. Metaeffector identification, to date, has depended on phenotypes in heterologous systems and experimental serendipity. ...
A defining feature of metaeffectors is direct, physical interaction with a target effector. Metaeffector identification, to date, has …
Structural basis for the toxicity of Legionella pneumophila effector SidH.
Sharma R, Adams M, Griffith-Jones S, Sahr T, Gomez-Valero L, Weis F, Hons M, Gharbi S, Berkane R, Stolz A, Buchrieser C, Bhogaraju S. Sharma R, et al. Nat Commun. 2023 Nov 3;14(1):7068. doi: 10.1038/s41467-023-42683-8. Nat Commun. 2023. PMID: 37923743 Free PMC article.
One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when overexpressed in host cells. SidH is regulated by the LP metaeffector LubX which targets SidH for degradation in a temporal manner during LP infection. ... …
One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when overexpressed in host …
Insights into Phakopsora pachyrhizi Effector-Effector Interactions.
Qi M, Yu H, Bredow M, Chicowski AS, Fields LD, Whitham SA. Qi M, et al. Mol Plant Microbe Interact. 2024 Mar;37(3):227-231. doi: 10.1094/MPMI-08-23-0120-FI. Epub 2024 Mar 12. Mol Plant Microbe Interact. 2024. PMID: 37831963 Free article.
The Sde Phosphoribosyl-Linked Ubiquitin Transferases protect the Legionella pneumophila vacuole from degradation by the host.
Kim S, Isberg RR. Kim S, et al. bioRxiv [Preprint]. 2023 Mar 20:2023.03.19.533379. doi: 10.1101/2023.03.19.533379. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2303942120. doi: 10.1073/pnas.2303942120. PMID: 36993347 Free PMC article. Updated. Preprint.
Sde protein protection of LCV lysis was only observed shortly after infection, presumably because Sde proteins are inactivated by the metaeffector SidJ during the course of infection. Deletion of SidJ extended the time that Sde proteins could prevent vacuole disruption, in …
Sde protein protection of LCV lysis was only observed shortly after infection, presumably because Sde proteins are inactivated by the met …
Intrabacterial Regulation of a Cytotoxic Effector by Its Cognate Metaeffector Promotes Legionella pneumophila Virulence.
Chauhan D, Joseph AM, Shames SR. Chauhan D, et al. mSphere. 2023 Feb 21;8(1):e0055222. doi: 10.1128/msphere.00552-22. Epub 2023 Jan 4. mSphere. 2023. PMID: 36598225 Free PMC article.
Regulation of the cytotoxic effector SidI by its cognate metaeffector, MesI, is critical for L. pneumophila virulence in natural and opportunistic hosts. ...L. pneumophila encodes a unique family of translocated effectors called metaeffectors, which bind and regulate the f …
Regulation of the cytotoxic effector SidI by its cognate metaeffector, MesI, is critical for L. pneumophila virulence in natural and …
Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae.
Martel A, Laflamme B, Breit-McNally C, Wang P, Lonjon F, Desveaux D, Guttman DS. Martel A, et al. PLoS Pathog. 2022 May 16;18(5):e1010541. doi: 10.1371/journal.ppat.1010541. eCollection 2022 May. PLoS Pathog. 2022. PMID: 35576228 Free PMC article.
We performed ETI suppression screens to test if metaeffector interactions contributed to these ETI differences, and found that HopQ1a suppressed AvrPto1m-mediated ETI, while HopG1c and HopF1g suppressed HopT1b-mediated ETI. Overall, these results show that P. syringae stra …
We performed ETI suppression screens to test if metaeffector interactions contributed to these ETI differences, and found that HopQ1a …
Expression and Functional Analysis of the Type III Secretion System Effector Repertoire of the Xylem Pathogen Erwinia tracheiphila on Cucurbits.
Olawole OI, Gleason ML, Beattie GA. Olawole OI, et al. Mol Plant Microbe Interact. 2022 Sep;35(9):768-778. doi: 10.1094/MPMI-01-22-0002-R. Epub 2022 Sep 13. Mol Plant Microbe Interact. 2022. PMID: 35471035 Free article.
These results highlight functional differences in effector inventories between two E. tracheiphila clades, provide the first evidence of OspG as a phytopathogen effector, and suggest that Eop1 may be a metaeffector influencing virulence. [Formula: see text] Copyright 2022 …
These results highlight functional differences in effector inventories between two E. tracheiphila clades, provide the first evidence of Osp …
22 results