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Crystal structure of the Legionella pneumophila effector SidL (Lpg0437) in complex with its metaeffector LegA11 (Lpg0436).
Machtens DA, Hutchison CA, Stein AM, Eberhage J, Willerding JM, Eschenburg S, Shames SR, Reubold TF. Machtens DA, et al. Virulence. 2026 Dec;17(1):2646775. doi: 10.1080/21505594.2026.2646775. Epub 2026 Mar 20. Virulence. 2026. PMID: 41843741 Free PMC article.
LegA11 (AnkJ/Lpg0436) has been identified as a metaeffector of SidL (Ceg14/Lpg0437), one of eight L. pneumophila effectors that inhibit host mRNA translation. ...These findings show that LegA11 is a metaeffector that contributes to suppression of host mRNA translati …
LegA11 (AnkJ/Lpg0436) has been identified as a metaeffector of SidL (Ceg14/Lpg0437), one of eight L. pneumophila effectors that inhib …
Crystal structure of the Legionella pneumophila effector SidL (Lpg0437) in complex with its metaeffector LegA11 (Lpg0436).
Machtens DA, Hutchison CA, Stein AM, Eberhage J, Willerding JM, Eschenburg S, Shames SR, Reubold TF. Machtens DA, et al. bioRxiv [Preprint]. 2025 Oct 23:2025.10.23.683979. doi: 10.1101/2025.10.23.683979. bioRxiv. 2025. Update in: Virulence. 2026 Dec;17(1):2646775. doi: 10.1080/21505594.2026.2646775. PMID: 41278709 Free PMC article. Updated. Preprint.
LegA11 (AnkJ/Lpg0436) has been identified as a putative metaeffector of SidL (Ceg14/Lpg0437), one of eight L. pneumophila effectors that inhibit host mRNA translation. ...These findings establish LegA11 as a bona fide metaeffector that contributes to suppression of …
LegA11 (AnkJ/Lpg0436) has been identified as a putative metaeffector of SidL (Ceg14/Lpg0437), one of eight L. pneumophila effectors t …
Legionella pneumophila modulates the host cytoskeleton by an effector of transglutaminase activity.
Liu Y, Liu Y, Luo ZQ. Liu Y, et al. mLife. 2025 Jun 18;4(3):232-248. doi: 10.1002/mlf2.70013. eCollection 2025 Jun. mLife. 2025. PMID: 40600052 Free PMC article.
Crosslink between actin and AMOT significantly reduces the binding between actin and its binding partner cofilin, suggesting that RavJ inhibits actin depolymerization. We also demonstrate that the metaeffector LegL1 directly interacts with RavJ to antagonize its TG activit …
Crosslink between actin and AMOT significantly reduces the binding between actin and its binding partner cofilin, suggesting that RavJ inhib …
Modulation of host ATP levels by secreted bacterial effectors.
He C, Li C, Liu Y, Chen TT, Li C, Chu X, Liu S, Wang L, Zhang Y, Ouyang S, Fu J, Song L, Luo ZQ. He C, et al. Nat Commun. 2025 May 20;16(1):4675. doi: 10.1038/s41467-025-60046-3. Nat Commun. 2025. PMID: 40394005 Free PMC article.
The activity of Ceg14 is regulated by its metaeffector AnkJ (Lpg0436, a.k.a. LegA11), which inhibits its ATPase activity via direct protein-protein interactions. ...
The activity of Ceg14 is regulated by its metaeffector AnkJ (Lpg0436, a.k.a. LegA11), which inhibits its ATPase activity via direct p …
A comprehensive two-hybrid analysis to explore the Legionella pneumophila effector-effector interactome.
Mount HO, Urbanus ML, Sheykhkarimli D, Coté AG, Laval F, Coppin G, Kishore N, Li R, Spirohn-Fitzgerald K, Petersen MO, Knapp JJ, Kim D-K, Twizere J-C, Calderwood MA, Vidal M, Roth FP, Ensminger AW. Mount HO, et al. mSystems. 2024 Dec 17;9(12):e0100424. doi: 10.1128/msystems.01004-24. Epub 2024 Nov 11. mSystems. 2024. PMID: 39526800 Free PMC article.
A defining feature of metaeffectors is direct, physical interaction with a target effector. Metaeffector identification, to date, has depended on phenotypes in heterologous systems and experimental serendipity. ...
A defining feature of metaeffectors is direct, physical interaction with a target effector. Metaeffector identification, to date, has …
Structural basis for the toxicity of Legionella pneumophila effector SidH.
Sharma R, Adams M, Griffith-Jones S, Sahr T, Gomez-Valero L, Weis F, Hons M, Gharbi S, Berkane R, Stolz A, Buchrieser C, Bhogaraju S. Sharma R, et al. Nat Commun. 2023 Nov 3;14(1):7068. doi: 10.1038/s41467-023-42683-8. Nat Commun. 2023. PMID: 37923743 Free PMC article.
One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when overexpressed in host cells. SidH is regulated by the LP metaeffector LubX which targets SidH for degradation in a temporal manner during LP infection. ... …
One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when overexpressed in host …
The Sde Phosphoribosyl-Linked Ubiquitin Transferases protect the Legionella pneumophila vacuole from degradation by the host.
Kim S, Isberg RR. Kim S, et al. bioRxiv [Preprint]. 2023 Mar 20:2023.03.19.533379. doi: 10.1101/2023.03.19.533379. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2303942120. doi: 10.1073/pnas.2303942120. PMID: 36993347 Free PMC article. Updated. Preprint.
Sde protein protection of LCV lysis was only observed shortly after infection, presumably because Sde proteins are inactivated by the metaeffector SidJ during the course of infection. Deletion of SidJ extended the time that Sde proteins could prevent vacuole disruption, in …
Sde protein protection of LCV lysis was only observed shortly after infection, presumably because Sde proteins are inactivated by the met …
Intrabacterial Regulation of a Cytotoxic Effector by Its Cognate Metaeffector Promotes Legionella pneumophila Virulence.
Chauhan D, Joseph AM, Shames SR. Chauhan D, et al. mSphere. 2023 Feb 21;8(1):e0055222. doi: 10.1128/msphere.00552-22. Epub 2023 Jan 4. mSphere. 2023. PMID: 36598225 Free PMC article.
Regulation of the cytotoxic effector SidI by its cognate metaeffector, MesI, is critical for L. pneumophila virulence in natural and opportunistic hosts. ...L. pneumophila encodes a unique family of translocated effectors called metaeffectors, which bind and regulate the f …
Regulation of the cytotoxic effector SidI by its cognate metaeffector, MesI, is critical for L. pneumophila virulence in natural and …
26 results