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Structural basis for protein glutamylation by the Legionella pseudokinase SidJ.
Adams M, Sharma R, Colby T, Weis F, Matic I, Bhogaraju S. Adams M, et al. Nat Commun. 2021 Oct 26;12(1):6174. doi: 10.1038/s41467-021-26429-y. Nat Commun. 2021. PMID: 34702826 Free PMC article.
To suppress the deleterious toxicity of SidE enzymes in a timely manner, LP employs a metaeffector named SidJ. Upon activation by host Calmodulin (CaM), SidJ executes an ATP-dependent glutamylation to modify the catalytic residue Glu860 in the mono-ADP-ribosyl transferase …
To suppress the deleterious toxicity of SidE enzymes in a timely manner, LP employs a metaeffector named SidJ. Upon activation by hos …
The metaeffector MesI regulates the activity of the Legionella effector SidI through direct protein-protein interactions.
McCloskey A, Perri K, Chen T, Han A, Luo ZQ. McCloskey A, et al. Microbes Infect. 2021 May-Jun;23(4-5):104794. doi: 10.1016/j.micinf.2021.104794. Epub 2021 Feb 8. Microbes Infect. 2021. PMID: 33571674
To avoid unwanted disruption of host physiology, this pathogen also imposes precise control of its virulence by the use of effectors called metaeffectors to regulate the activity of other effectors. A number of effector/metaeffector pairs with distinct regulatory mechanism …
To avoid unwanted disruption of host physiology, this pathogen also imposes precise control of its virulence by the use of effectors called …
Affecting the Effectors: Regulation of Legionella pneumophila Effector Function by Metaeffectors.
Joseph AM, Shames SR. Joseph AM, et al. Pathogens. 2021 Jan 22;10(2):108. doi: 10.3390/pathogens10020108. Pathogens. 2021. PMID: 33499048 Free PMC article. Review.
At least one dozen metaeffectors are encoded by L. pneumophila; however, mechanisms by which they promote virulence are largely unknown. This review details current knowledge of L pneumophila metaeffector function, challenges associated with their identification, and poten …
At least one dozen metaeffectors are encoded by L. pneumophila; however, mechanisms by which they promote virulence are largely unknown. Thi …
The Legionella pneumophila Metaeffector Lpg2505 (MesI) Regulates SidI-Mediated Translation Inhibition and Novel Glycosyl Hydrolase Activity.
Joseph AM, Pohl AE, Ball TJ, Abram TG, Johnson DK, Geisbrecht BV, Shames SR. Joseph AM, et al. Infect Immun. 2020 Apr 20;88(5):e00853-19. doi: 10.1128/IAI.00853-19. Print 2020 Apr 20. Infect Immun. 2020. PMID: 32122942 Free PMC article.
Several effectors, called metaeffectors, function to regulate the activity of other Dot/Icm-translocated effectors during infection. The metaeffector Lpg2505 is essential for L. pneumophila intracellular replication only when its cognate effector, SidI, is present. ...We a …
Several effectors, called metaeffectors, function to regulate the activity of other Dot/Icm-translocated effectors during infection. The …
Multiple Legionella pneumophila effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries.
Shames SR, Liu L, Havey JC, Schofield WB, Goodman AL, Roy CR. Shames SR, et al. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10446-E10454. doi: 10.1073/pnas.1708553114. Epub 2017 Nov 13. Proc Natl Acad Sci U S A. 2017. PMID: 29133401 Free PMC article.
Further analysis of Lpg2505 revealed that this protein functions as a metaeffector that counteracts host cytotoxicity displayed by the effector protein SidI. ...
Further analysis of Lpg2505 revealed that this protein functions as a metaeffector that counteracts host cytotoxicity displayed by th …
Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila.
Urbanus ML, Quaile AT, Stogios PJ, Morar M, Rao C, Di Leo R, Evdokimova E, Lam M, Oatway C, Cuff ME, Osipiuk J, Michalska K, Nocek BP, Taipale M, Savchenko A, Ensminger AW. Urbanus ML, et al. Mol Syst Biol. 2016 Dec 16;12(12):893. doi: 10.15252/msb.20167381. Mol Syst Biol. 2016. PMID: 27986836 Free PMC article.
Through detailed structural and functional analysis, we show that metaeffector activity derives from a diverse range of mechanisms, shapes evolution, and can be used to reveal important aspects of each cognate effector's function. ...
Through detailed structural and functional analysis, we show that metaeffector activity derives from a diverse range of mechanisms, s …
Spatiotemporal regulation of a Legionella pneumophila T4SS substrate by the metaeffector SidJ.
Jeong KC, Sexton JA, Vogel JP. Jeong KC, et al. PLoS Pathog. 2015 Mar 16;11(3):e1004695. doi: 10.1371/journal.ppat.1004695. eCollection 2015 Mar. PLoS Pathog. 2015. PMID: 25774515 Free PMC article.
Finally, we were able to demonstrate both in vivo and in vitro that SidJ acts on SidE proteins to mediate their disappearance from the LCV, thereby preventing lethal intoxication of host cells. Based on these findings, we propose that SidJ acts as a metaeffector to control …
Finally, we were able to demonstrate both in vivo and in vitro that SidJ acts on SidE proteins to mediate their disappearance from the LCV, …
12 results