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Intrabacterial Regulation of a Cytotoxic Effector by Its Cognate Metaeffector Promotes Legionella pneumophila Virulence.
Chauhan D, Joseph AM, Shames SR. Chauhan D, et al. mSphere. 2023 Jan 4:e0055222. doi: 10.1128/msphere.00552-22. Online ahead of print. mSphere. 2023. PMID: 36598225 Free article.
Regulation of the cytotoxic effector SidI by its cognate metaeffector, MesI, is critical for L. pneumophila virulence in natural and opportunistic hosts. ...L. pneumophila encodes a unique family of translocated effectors called metaeffectors, which bind and regulate the f …
Regulation of the cytotoxic effector SidI by its cognate metaeffector, MesI, is critical for L. pneumophila virulence in natural and …
Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae.
Martel A, Laflamme B, Breit-McNally C, Wang P, Lonjon F, Desveaux D, Guttman DS. Martel A, et al. PLoS Pathog. 2022 May 16;18(5):e1010541. doi: 10.1371/journal.ppat.1010541. eCollection 2022 May. PLoS Pathog. 2022. PMID: 35576228 Free PMC article.
Although most of these differences were quantitative, three ETI responses were completely absent in one of the pathogenic backgrounds. We performed ETI suppression screens to test if metaeffector interactions contributed to these ETI differences, and found that HopQ1a supp …
Although most of these differences were quantitative, three ETI responses were completely absent in one of the pathogenic backgrounds. We pe …
Expression and Functional Analysis of the Type III Secretion System Effector Repertoire of the Xylem Pathogen Erwinia tracheiphila on Cucurbits.
Olawole OI, Gleason ML, Beattie GA. Olawole OI, et al. Mol Plant Microbe Interact. 2022 Sep;35(9):768-778. doi: 10.1094/MPMI-01-22-0002-R. Epub 2022 Sep 13. Mol Plant Microbe Interact. 2022. PMID: 35471035 Free article.
These results highlight functional differences in effector inventories between two E. tracheiphila clades, provide the first evidence of OspG as a phytopathogen effector, and suggest that Eop1 may be a metaeffector influencing virulence. [Formula: see text] Copyright 2022 …
These results highlight functional differences in effector inventories between two E. tracheiphila clades, provide the first evidence of Osp …
Structural basis for protein glutamylation by the Legionella pseudokinase SidJ.
Adams M, Sharma R, Colby T, Weis F, Matic I, Bhogaraju S. Adams M, et al. Nat Commun. 2021 Oct 26;12(1):6174. doi: 10.1038/s41467-021-26429-y. Nat Commun. 2021. PMID: 34702826 Free PMC article.
To suppress the deleterious toxicity of SidE enzymes in a timely manner, LP employs a metaeffector named SidJ. Upon activation by host Calmodulin (CaM), SidJ executes an ATP-dependent glutamylation to modify the catalytic residue Glu860 in the mono-ADP-ribosyl transferase …
To suppress the deleterious toxicity of SidE enzymes in a timely manner, LP employs a metaeffector named SidJ. Upon activation by hos …
The metaeffector MesI regulates the activity of the Legionella effector SidI through direct protein-protein interactions.
McCloskey A, Perri K, Chen T, Han A, Luo ZQ. McCloskey A, et al. Microbes Infect. 2021 May-Jun;23(4-5):104794. doi: 10.1016/j.micinf.2021.104794. Epub 2021 Feb 8. Microbes Infect. 2021. PMID: 33571674 Free PMC article.
To avoid unwanted disruption of host physiology, this pathogen also imposes precise control of its virulence by the use of effectors called metaeffectors to regulate the activity of other effectors. A number of effector/metaeffector pairs with distinct regulatory mechanism …
To avoid unwanted disruption of host physiology, this pathogen also imposes precise control of its virulence by the use of effectors called …
Affecting the Effectors: Regulation of Legionella pneumophila Effector Function by Metaeffectors.
Joseph AM, Shames SR. Joseph AM, et al. Pathogens. 2021 Jan 22;10(2):108. doi: 10.3390/pathogens10020108. Pathogens. 2021. PMID: 33499048 Free PMC article. Review.
At least one dozen metaeffectors are encoded by L. pneumophila; however, mechanisms by which they promote virulence are largely unknown. This review details current knowledge of L pneumophila metaeffector function, challenges associated with their identification, and poten …
At least one dozen metaeffectors are encoded by L. pneumophila; however, mechanisms by which they promote virulence are largely unknown. Thi …
The Legionella pneumophila Metaeffector Lpg2505 (MesI) Regulates SidI-Mediated Translation Inhibition and Novel Glycosyl Hydrolase Activity.
Joseph AM, Pohl AE, Ball TJ, Abram TG, Johnson DK, Geisbrecht BV, Shames SR. Joseph AM, et al. Infect Immun. 2020 Apr 20;88(5):e00853-19. doi: 10.1128/IAI.00853-19. Print 2020 Apr 20. Infect Immun. 2020. PMID: 32122942 Free PMC article.
Several effectors, called metaeffectors, function to regulate the activity of other Dot/Icm-translocated effectors during infection. The metaeffector Lpg2505 is essential for L. pneumophila intracellular replication only when its cognate effector, SidI, is present. ...We a …
Several effectors, called metaeffectors, function to regulate the activity of other Dot/Icm-translocated effectors during infection. The …
16 results