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Structural basis for the toxicity of Legionella pneumophila effector SidH.
Sharma R, Adams M, Griffith-Jones S, Sahr T, Gomez-Valero L, Weis F, Hons M, Gharbi S, Berkane R, Stolz A, Buchrieser C, Bhogaraju S. Sharma R, et al. Nat Commun. 2023 Nov 3;14(1):7068. doi: 10.1038/s41467-023-42683-8. Nat Commun. 2023. PMID: 37923743 Free PMC article.
One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when overexpressed in host cells. SidH is regulated by the LP metaeffector LubX which targets SidH for degradation in a temporal manner during LP infection. ... …
One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when overexpressed in host …
Insights into Phakopsora pachyrhizi Effector-Effector Interactions.
Qi M, Yu H, Bredow M, Chicowski AS, Fields LD, Whitham SA. Qi M, et al. Mol Plant Microbe Interact. 2024 Mar;37(3):227-231. doi: 10.1094/MPMI-08-23-0120-FI. Epub 2024 Mar 12. Mol Plant Microbe Interact. 2024. PMID: 37831963 Free article.
The Sde Phosphoribosyl-Linked Ubiquitin Transferases protect the Legionella pneumophila vacuole from degradation by the host.
Kim S, Isberg RR. Kim S, et al. bioRxiv [Preprint]. 2023 Mar 20:2023.03.19.533379. doi: 10.1101/2023.03.19.533379. bioRxiv. 2023. PMID: 36993347 Free PMC article. Updated. Preprint.
Sde protein protection of LCV lysis was only observed shortly after infection, presumably because Sde proteins are inactivated by the metaeffector SidJ during the course of infection. Deletion of SidJ extended the time that Sde proteins could prevent vacuole disruption, in …
Sde protein protection of LCV lysis was only observed shortly after infection, presumably because Sde proteins are inactivated by the met …
Intrabacterial Regulation of a Cytotoxic Effector by Its Cognate Metaeffector Promotes Legionella pneumophila Virulence.
Chauhan D, Joseph AM, Shames SR. Chauhan D, et al. mSphere. 2023 Feb 21;8(1):e0055222. doi: 10.1128/msphere.00552-22. Epub 2023 Jan 4. mSphere. 2023. PMID: 36598225 Free PMC article.
Regulation of the cytotoxic effector SidI by its cognate metaeffector, MesI, is critical for L. pneumophila virulence in natural and opportunistic hosts. ...L. pneumophila encodes a unique family of translocated effectors called metaeffectors, which bind and regulate the f …
Regulation of the cytotoxic effector SidI by its cognate metaeffector, MesI, is critical for L. pneumophila virulence in natural and …
Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae.
Martel A, Laflamme B, Breit-McNally C, Wang P, Lonjon F, Desveaux D, Guttman DS. Martel A, et al. PLoS Pathog. 2022 May 16;18(5):e1010541. doi: 10.1371/journal.ppat.1010541. eCollection 2022 May. PLoS Pathog. 2022. PMID: 35576228 Free PMC article.
Although most of these differences were quantitative, three ETI responses were completely absent in one of the pathogenic backgrounds. We performed ETI suppression screens to test if metaeffector interactions contributed to these ETI differences, and found that HopQ1a supp …
Although most of these differences were quantitative, three ETI responses were completely absent in one of the pathogenic backgrounds. We pe …
Expression and Functional Analysis of the Type III Secretion System Effector Repertoire of the Xylem Pathogen Erwinia tracheiphila on Cucurbits.
Olawole OI, Gleason ML, Beattie GA. Olawole OI, et al. Mol Plant Microbe Interact. 2022 Sep;35(9):768-778. doi: 10.1094/MPMI-01-22-0002-R. Epub 2022 Sep 13. Mol Plant Microbe Interact. 2022. PMID: 35471035 Free article.
These results highlight functional differences in effector inventories between two E. tracheiphila clades, provide the first evidence of OspG as a phytopathogen effector, and suggest that Eop1 may be a metaeffector influencing virulence. [Formula: see text] Copyright 2022 …
These results highlight functional differences in effector inventories between two E. tracheiphila clades, provide the first evidence of Osp …
Structural basis for protein glutamylation by the Legionella pseudokinase SidJ.
Adams M, Sharma R, Colby T, Weis F, Matic I, Bhogaraju S. Adams M, et al. Nat Commun. 2021 Oct 26;12(1):6174. doi: 10.1038/s41467-021-26429-y. Nat Commun. 2021. PMID: 34702826 Free PMC article.
To suppress the deleterious toxicity of SidE enzymes in a timely manner, LP employs a metaeffector named SidJ. Upon activation by host Calmodulin (CaM), SidJ executes an ATP-dependent glutamylation to modify the catalytic residue Glu860 in the mono-ADP-ribosyl transferase …
To suppress the deleterious toxicity of SidE enzymes in a timely manner, LP employs a metaeffector named SidJ. Upon activation by hos …
The metaeffector MesI regulates the activity of the Legionella effector SidI through direct protein-protein interactions.
McCloskey A, Perri K, Chen T, Han A, Luo ZQ. McCloskey A, et al. Microbes Infect. 2021 May-Jun;23(4-5):104794. doi: 10.1016/j.micinf.2021.104794. Epub 2021 Feb 8. Microbes Infect. 2021. PMID: 33571674 Free PMC article.
To avoid unwanted disruption of host physiology, this pathogen also imposes precise control of its virulence by the use of effectors called metaeffectors to regulate the activity of other effectors. A number of effector/metaeffector pairs with distinct regulatory mechanism …
To avoid unwanted disruption of host physiology, this pathogen also imposes precise control of its virulence by the use of effectors called …
20 results