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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1923 1
1955 1
1957 1
1964 5
1965 1
1966 2
1969 3
1970 4
1972 1
1973 1
1975 1
1976 2
1977 1
1979 3
1981 1
1982 5
1983 1
1985 1
1986 1
1987 2
1988 1
1989 1
1991 1
1993 4
1994 1
1995 5
1996 2
1997 2
1998 5
1999 5
2000 3
2002 3
2003 1
2004 4
2005 4
2006 5
2007 6
2008 5
2009 3
2010 1
2011 6
2012 10
2013 8
2014 14
2015 18
2016 13
2017 16
2018 15
2019 13
2020 12
2021 10
2022 6
2023 7
2024 5

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227 results

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Page 1
The Potentials of Methylene Blue as an Anti-Aging Drug.
Xue H, Thaivalappil A, Cao K. Xue H, et al. Cells. 2021 Dec 1;10(12):3379. doi: 10.3390/cells10123379. Cells. 2021. PMID: 34943887 Free PMC article. Review.
Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. ...This leads to increaseding oxidative stress and results in downstream phenotypes under age-related conditions. MB can bypass Complex I/III activity in mitocho …
Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. ...This leads to increas …
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation.
Yang L, Youngblood H, Wu C, Zhang Q. Yang L, et al. Transl Neurodegener. 2020 Jun 1;9(1):19. doi: 10.1186/s40035-020-00197-z. Transl Neurodegener. 2020. PMID: 32475349 Free PMC article. Review.
Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress, which are important factors contributing to the development of brain disease. Ample evidence suggests mitochondria are a promising target for neuroprotection. Recentl …
Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress, which are important factors contr …
From Mitochondrial Function to Neuroprotection-an Emerging Role for Methylene Blue.
Tucker D, Lu Y, Zhang Q. Tucker D, et al. Mol Neurobiol. 2018 Jun;55(6):5137-5153. doi: 10.1007/s12035-017-0712-2. Epub 2017 Aug 24. Mol Neurobiol. 2018. PMID: 28840449 Free PMC article. Review.
Methylene blue (MB) is a well-established drug with a long history of use, owing to its diverse range of use and its minimal side effect profile. ...Mitochondrial dysfunction has been identified as a seemingly unifying pathological phenomenon across a wide range of …
Methylene blue (MB) is a well-established drug with a long history of use, owing to its diverse range of use and its minimal s …
Parallel damage in mitochondria and lysosomes is an efficient way to photoinduce cell death.
Martins WK, Santos NF, Rocha CS, Bacellar IOL, Tsubone TM, Viotto AC, Matsukuma AY, Abrantes ABP, Siani P, Dias LG, Baptista MS. Martins WK, et al. Autophagy. 2019 Feb;15(2):259-279. doi: 10.1080/15548627.2018.1515609. Epub 2018 Sep 25. Autophagy. 2019. PMID: 30176156 Free PMC article.
Specific damage to these organelles was induced by irradiation of cells pretreated with 2 phenothiazinium salts, methylene blue (MB) and 1,9-dimethyl methylene blue (DMMB). At a low concentration level (10 nM), only DMMB could induce mitochondrial dama …
Specific damage to these organelles was induced by irradiation of cells pretreated with 2 phenothiazinium salts, methylene blue …
Recent advances in drug delivery systems for targeting cancer stem cells.
Duan H, Liu Y, Gao Z, Huang W. Duan H, et al. Acta Pharm Sin B. 2021 Jan;11(1):55-70. doi: 10.1016/j.apsb.2020.09.016. Epub 2020 Oct 2. Acta Pharm Sin B. 2021. PMID: 33532180 Free PMC article. Review.
A series of corresponding promising therapeutic strategies based on CSC targeting, such as the targeting of CSC niche, CSC signaling pathways, and CSC mitochondria, are currently under development. Given the rapid progression in this field and nanotechnology, drug delivery …
A series of corresponding promising therapeutic strategies based on CSC targeting, such as the targeting of CSC niche, CSC signaling pathway …
Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase.
Atamna H, Kumar R. Atamna H, et al. J Alzheimers Dis. 2010;20 Suppl 2:S439-52. doi: 10.3233/JAD-2010-100414. J Alzheimers Dis. 2010. PMID: 20463399 Review.
This review discusses two potential approaches to delay the onset of AD. The first approach is use of diaminophenothiazines (e.g., methylene blue; MB) to prevent mitochondrial dysfunction and to attenuate energy hypometabolism. ...We propose that the cycling of MB b …
This review discusses two potential approaches to delay the onset of AD. The first approach is use of diaminophenothiazines (e.g., methyl …
The Effect of Methylene Blue and Its Metabolite-Azure I-on Bioenergetic Parameters of Intact Mouse Brain Mitochondria.
Gureev AP, Samoylova NA, Potanina DV, Popov VN. Gureev AP, et al. Biochem Mosc Suppl B Biomed Chem. 2022;16(2):148-153. doi: 10.1134/S1990750822020044. Epub 2022 May 17. Biochem Mosc Suppl B Biomed Chem. 2022. PMID: 35601460 Free PMC article.
Methylene blue, a phenothiazine dye, that is widely used in medicine and is under clinical trials as an agent for treatment of Alzheimer's disease. ...Azure I, an N-dimethylated metabolite of methylene blue, is potentially a more effective compound tha …
Methylene blue, a phenothiazine dye, that is widely used in medicine and is under clinical trials as an agent for treatment of …
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
Mao J, Wang D, Wang D, Wu Q, Shang Q, Gao C, Wang H, Wang H, Du M, Peng P, Jia H, Xu X, Wang J, Yang L, Luo Z. Mao J, et al. Exp Mol Med. 2023 Jan;55(1):253-268. doi: 10.1038/s12276-023-00928-y. Epub 2023 Jan 18. Exp Mol Med. 2023. PMID: 36653443 Free PMC article.
However, it is still unclear whether succinylation or SIRT5 is involved in the impairment of mitochondria and development of IDD induced by excessive mechanical stress. ...Finally, we validated the efficacy of treatments targeting disrupted mitochondrial protein importatio …
However, it is still unclear whether succinylation or SIRT5 is involved in the impairment of mitochondria and development of IDD indu …
Methylene Blue Bridges the Inhibition and Produces Unusual Respiratory Changes in Complex III-Inhibited Mitochondria. Studies on Rats, Mice and Guinea Pigs.
Sváb G, Kokas M, Sipos I, Ambrus A, Tretter L. Sváb G, et al. Antioxidants (Basel). 2021 Feb 16;10(2):305. doi: 10.3390/antiox10020305. Antioxidants (Basel). 2021. PMID: 33669457 Free PMC article.
Methylene blue (MB) is used in human therapy in various pathological conditions. ...Recently, the beneficial effects of MB exerted on complex III-inhibited mitochondria were debated. In the present contribution, several pieces of evidence are provided towards …
Methylene blue (MB) is used in human therapy in various pathological conditions. ...Recently, the beneficial effects of MB exe …
[Effect of methylene blue and its metabolite - azure I - on bioenergetic parameters of intact mice brain mitochondria].
Gureev AP, Samoylova NA, Potanina DV, Popov VN. Gureev AP, et al. Biomed Khim. 2021 Nov;67(6):485-490. doi: 10.18097/PBMC20216706485. Biomed Khim. 2021. PMID: 34964442 Russian.
Methylene blue is a phenothiazine dye that is widely used in medicine and clinical trials for the treatment of Alzheimer's disease. ...Azure I, an N-dimethylated metabolite of methylene blue, is potentially a more effective compound than methylene …
Methylene blue is a phenothiazine dye that is widely used in medicine and clinical trials for the treatment of Alzheimer's dis …
227 results