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METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression.
Xia P, Zhang H, Lu H, Xu K, Jiang X, Jiang Y, Gongye X, Chen Z, Liu J, Chen X, Ma W, Zhang Z, Yuan Y. Xia P, et al. Cancer Commun (Lond). 2023 Mar;43(3):338-364. doi: 10.1002/cac2.12403. Epub 2023 Jan 5. Cancer Commun (Lond). 2023. PMID: 36602428 Free PMC article.
Furthermore, we identified cAMP responsive element binding protein 1 (CREB1)/P300 as a critical transcriptional regulator of METTL5 that promoted the transcription of METTL5 in HCC. In patient-derived tumor xenograft (PDX) models, adenovirus-mediated knockout of …
Furthermore, we identified cAMP responsive element binding protein 1 (CREB1)/P300 as a critical transcriptional regulator of METTL5 t …
METTL5-mediated 18S rRNA m(6)A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression.
Dai Z, Zhu W, Hou Y, Zhang X, Ren X, Lei K, Liao J, Liu H, Chen Z, Peng S, Li S, Lin S, Kuang M. Dai Z, et al. Mol Ther. 2023 Nov 1;31(11):3225-3242. doi: 10.1016/j.ymthe.2023.09.014. Epub 2023 Sep 21. Mol Ther. 2023. PMID: 37735874

Here, we found that 18S rRNA m(6)A modification and its methyltransferase METTL5 were aberrantly upregulated in ICC and associated with poorer survival (log rank test, p < 0.05). ...The oncogenic function of METTL5 is corroborated using liver-specific knockout an

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Here, we found that 18S rRNA m(6)A modification and its methyltransferase METTL5 were aberrantly upregulated in ICC and associated wi …
The emerging importance of METTL5-mediated ribosomal RNA methylation.
Turkalj EM, Vissers C. Turkalj EM, et al. Exp Mol Med. 2022 Oct;54(10):1617-1625. doi: 10.1038/s12276-022-00869-y. Epub 2022 Oct 21. Exp Mol Med. 2022. PMID: 36266443 Free PMC article. Review.
In particular, the m(6)A modification at the A-1832 position of the 18S rRNA is installed by METTL5. Mutations or deletions of Mettl5 in humans and mice, respectively, cause abnormal translation and gene expression that in turn mediates stem cell behaviors such as d …
In particular, the m(6)A modification at the A-1832 position of the 18S rRNA is installed by METTL5. Mutations or deletions of Met …
RNA m6A methylation across the transcriptome.
Sendinc E, Shi Y. Sendinc E, et al. Mol Cell. 2023 Feb 2;83(3):428-441. doi: 10.1016/j.molcel.2023.01.006. Mol Cell. 2023. PMID: 36736310 Free article. Review.
The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation.
Sepich-Poore C, Zheng Z, Schmitt E, Wen K, Zhang ZS, Cui XL, Dai Q, Zhu AC, Zhang L, Sanchez Castillo A, Tan H, Peng J, Zhuang X, He C, Nachtergaele S. Sepich-Poore C, et al. J Biol Chem. 2022 Mar;298(3):101590. doi: 10.1016/j.jbc.2022.101590. Epub 2022 Jan 14. J Biol Chem. 2022. PMID: 35033535 Free PMC article.
Our work supports findings that TRMT112 is required for METTL5 stability and reveals that human METTL5 mutations associated with microcephaly and intellectual disability disrupt this interaction. We show that loss of METTL5 in human cancer cell lines and in m …
Our work supports findings that TRMT112 is required for METTL5 stability and reveals that human METTL5 mutations associated wi …
Mettl5 mediated 18S rRNA N6-methyladenosine (m(6)A) modification controls stem cell fate determination and neural function.
Wang L, Liang Y, Lin R, Xiong Q, Yu P, Ma J, Cheng M, Han H, Wang X, Wang G, Liang F, Pei Z, Chen D, Yuan Q, Jiang YZ, Lin S. Wang L, et al. Genes Dis. 2020 Jul 17;9(1):268-274. doi: 10.1016/j.gendis.2020.07.004. eCollection 2022 Jan. Genes Dis. 2020. PMID: 35005123 Free PMC article.
In this study, we identified METTL5 protein complex and revealed that METTL5 mainly interacts with RNA binding proteins and ribosome proteins. ...Moreover, using Mettl5 knockout mouse model, we further demonstrated that Mettl5 knockout mice exhibit int …
In this study, we identified METTL5 protein complex and revealed that METTL5 mainly interacts with RNA binding proteins and ri …
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.
van Tran N, Ernst FGM, Hawley BR, Zorbas C, Ulryck N, Hackert P, Bohnsack KE, Bohnsack MT, Jaffrey SR, Graille M, Lafontaine DLJ. van Tran N, et al. Nucleic Acids Res. 2019 Sep 5;47(15):7719-7733. doi: 10.1093/nar/gkz619. Nucleic Acids Res. 2019. PMID: 31328227 Free PMC article.
We show that METTL5 must form a heterodimeric complex with TRMT112, a known methyltransferase activator, to gain metabolic stability in cells. We provide the first atomic resolution structure of METTL5-TRMT112, supporting that its RNA-binding mode differs distinctly …
We show that METTL5 must form a heterodimeric complex with TRMT112, a known methyltransferase activator, to gain metabolic stability …
METTL5 promotes gastric cancer progression via sphingomyelin metabolism.
Zhang YQ, Li J, Qin Z, Li DM, Ye FZ, Bei SH, Zhang XH, Feng L. Zhang YQ, et al. World J Gastrointest Oncol. 2024 May 15;16(5):1925-1946. doi: 10.4251/wjgo.v16.i5.1925. World J Gastrointest Oncol. 2024. PMID: 38764837 Free PMC article.
An increased level of METTL5 correlated with a high degree of m6A methylation. METTL5 markedly promotes the proliferation, migration, and invasion of GC cells in vitro. METTL5 also promotes the growth of GC in animal models. METTL5 knockdown resulted i …
An increased level of METTL5 correlated with a high degree of m6A methylation. METTL5 markedly promotes the proliferation, mig …
METTL5 serves as a diagnostic and prognostic biomarker in hepatocellular carcinoma by influencing the immune microenvironment.
Wang L, Peng JL. Wang L, et al. Sci Rep. 2023 Jul 3;13(1):10755. doi: 10.1038/s41598-023-37807-5. Sci Rep. 2023. PMID: 37400463 Free PMC article.
This study aims to elucidate the influences of METTL5 on the carcinogenesis and progression of HCC. Expressions of METTL5 gene, transcript, protein, and promoter methylation in HCC were examined through multiple databases, c-BioPortal was used to confirm the genomic …
This study aims to elucidate the influences of METTL5 on the carcinogenesis and progression of HCC. Expressions of METTL5 gene …
51 results